Compositions and method for storing liquid biospecimens
This disclosure describes a lyoprotectant matrix, compositions including the lyoprotectant matrix and methods for storing a liquid biospecimen using the lyoprotectant matrix. Generally, the lyoprotectant matrix includes a non-woven web having fibers having, as components, at least one lyoprotective carbohydrate and at least one polymer. The matrix further possesses an apparent pore size of 0.1 μm to 500 μm.
1. A lyoprotectant matrix comprising:
a non-woven web comprising:
fibers comprising:
an average diameter of 2 μm to 6 μm and comprising:
at least one lyoprotective carbohydrate;
at least one polymer; and
excipients comprising glycerol, Polyethylene glycol (PEG), polysorbate 20, gluconic acid, and glucamine; and
an apparent pore size of 0.1 μm to 500 μm.
2. The lyoprotectant matrix of claim 1 wherein the lyoprotective carbohydrate comprises a monosaccharide or a disaccharide.
3. The lyoprotectant matrix of claim 1 wherein the lyoprotective carbohydrate comprises trehalose.
4. The lyoprotectant matrix of claim 1 wherein the polymer comprises dextran.
5. A lyoprotectant matrix comprising:
a non-woven web of fibers consisting essentially of:
at least one lyoprotective carbohydrate;
at least one polymer;
excipients comprising glycerol, polysorbate 20, gluconic acid, and glucamine; and
water,
the fibers having an average diameter of 2 μm to 6 μm and the web having an apparent pore size of 0.1 μm to 500 μm.