Tube crimping arrangement for drug delivery device

1. A drug delivery system for injecting a medicament, the system comprising:

a container configured to receive a medicament;

a drive assembly which, upon actuation, is configured to expel the medicament from the container;

a needle for injecting the medicament to a patient;

a needle actuator assembly comprising a movable portion biased by a biasing member and configured to move the needle between a pre-use position, a use position for delivery of the medicament to the patient, and a post-use position after delivery of the medicament is completed;

a fluid path assembly comprising a tube in fluid communication with the container and the needle for conducting fluid from the container to the needle; and

a tube crimping arrangement configured to engage the tube to block fluid flow through the tube,

wherein after a dose of the medicament has been delivered to the patient through the needle, the drive assembly moves the movable portion of the needle actuator assembly to contact a portion of the tube crimping arrangement, which presses the tube crimping arrangement against the tube to at least partially restrict fluid flow through the tube.

2. The system of claim 1 , wherein, upon actuation, the drive assembly automatically causes the tube crimping arrangement to restrict fluid flow through the tube.

3. The system of claim 1 , further comprising a housing enclosing at least a portion of the container, drive assembly, needle, fluid path assembly, and tube crimping arrangement, the housing comprising a top cover engaged to a bottom cover.

4. The system of claim 1 , further comprising a housing enclosing at least a portion of the container, drive assembly, needle, fluid path assembly, and tube crimping arrangement, wherein the needle is retracted into the housing in the pre-use and post use positions.

5. The system of claim 4 , wherein at least a portion of the needle is extended from the housing in the use position.

6. The system of claim 1 , wherein, upon actuation, the drive assembly automatically causes the needle actuator assembly to transition the needle between the use position and the post-use position.

7. A drug delivery system for injecting a medicament, the system comprising:

a container configured to receive a medicament;

a drive assembly which, upon actuation, is configured to expel the medicament from the container;

a needle for injecting the medicament to a patient;

a needle actuator assembly comprising a movable portion biased by a biasing member and configured to move the needle between a pre-use position, a use position for delivery of the medicament to the patient, and a post-use position after delivery of the medicament is completed;

a fluid path assembly comprising a tube in fluid communication with the container and the needle for conducting fluid from the container to the needle; and

a tube crimping arrangement configured to engage the tube to block fluid flow through the tube,

wherein the drive assembly causes the tube crimping arrangement to engage the tube after a dose of the medicament has been delivered to the patient through the needle and wherein the tube crimping arrangement comprises at least one tube crimping member configured to be driven toward the tube by contact with the movable portion of the needle actuation assembly.

8. The system of claim 7 , further comprising a housing enclosing at least a portion of the container, drive assembly, needle, and fluid path assembly, wherein the at least one crimping member comprises one or more flexible blades pivotally mounted to a portion of the housing.

9. The system of claim 8 , wherein the movable portion of the needle actuator assembly comprises one or more protruding features extending therefrom, the protruding features being configured to contact the flexible blades to drive the flexible blades towards the tube.

10. The system of claim 7 , further comprising a housing enclosing at least a portion of the container, drive assembly, needle, and fluid path assembly, and wherein the at least one crimping member comprises two flexible blades pivotally mounted to a portion of the housing and defining a gap therebetween.

11. The system of claim 10 , wherein the movable portion of the needle actuator assembly comprises a first set of pins positioned to deflect the two flexible blades away from one another to expand the gap, and a second set of pins positioned to drive the two flexible blades towards one another to contact the tube.

12. The system of claim 11 , wherein the movable portion of the needle actuator assembly comprises a ridge configured to press the tube into the gap, when the gap is expanded by contact between the first set of pins and the flexible blades.

13. The system of claim 7 , wherein the biasing member of the needle actuator assembly exerts a force of 1 N or less on the tube crimping arrangement.

14. A drug delivery system for injecting a medicament, the system comprising:

a container configured to receive a medicament;

a drive assembly which, upon actuation, is configured to expel the medicament from the container;

a needle for injecting the medicament to a patient;

a fluid path assembly comprising a tube in fluid communication with the container and the needle for conducting fluid from the container to the needle; and

a tube crimping arrangement configured to engage the tube to block fluid flow through the tube,

wherein the drive assembly causes the tube crimping arrangement to engage the tube after a dose of the medicament has been delivered to the patient through the needle and wherein the tube comprises a flexible single walled tube having a diameter of 0.7 mm or less.