System and method for non-invasive monitoring of hemoglobin
A method of non-invasively monitoring hemoglobin concentration includes providing incident light to patient tissue at a first excitation wavelength. The method further includes monitoring a first emission response at a first emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response, and monitoring a second emission response at a second emission wavelength, wherein the second emission wavelength is selected to correspond with a minimum of the emission response. A hemoglobin concentration is calculated based on a ratio of the first emission response to the second emission response.
1. A system for non-invasive monitoring of hemoglobin concentration level, the system comprising:
a medical device comprising:
at least one light source configured to provide light to patient tissue;
a first photodetector configured to monitor an emission response at a first emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response of a hemoglobin component, wherein the hemoglobin component comprises at least one of oxyhemoglobin or de-oxyhemoglobin; and
a second photodetector configured to monitor the emission response at a second emission wavelength, wherein the second emission wavelength is selected to correspond with a minimum of the emission response of the hemoglobin component; and
one or more processors configured to receive the emission responses at the first emission wavelength and the second emission wavelength, wherein the one or more processors are configured to calculate a ratio based on the received emission responses and utilize the calculated ratio to determine the hemoglobin concentration level.
2. The system of claim 1 , wherein the hemoglobin component is oxyhemoglobin and the hemoglobin concentration level is an oxyhemoglobin concentration level, wherein the first emission wavelength is selected to correspond with a maximum of an oxyhemoglobin emission response and the second emission wavelength is selected to correspond with a minimum of the oxyhemoglobin emission response.
3. The system of claim 1 , wherein the hemoglobin component is de-oxyhemoglobin and the hemoglobin concentration level is a de-oxyhemoglobin concentration level, wherein the first emission wavelength is selected to correspond with a maximum of a de-oxyhemoglobin emission response and the second emission wavelength is selected to correspond with a minimum of the de-oxyhemoglobin emission response.
4. The system of claim 1 , wherein the one or more processors are configured to control generation of an alert in response to the hemoglobin concentration level falling below a threshold value, indicating anemia or change in the hemoglobin component.
5. The system of claim 1 , wherein the hemoglobin concentration level is determined in real-time or near real-time by the one or more processors.
6. The system of claim 1 , wherein the one or more processors are configured to collect and store a plurality of determined hemoglobin concentration levels over a first monitoring period, and provide an output of trends in monitored hemoglobin concentration levels.
7. The system of claim 1 , wherein the medical device further includes sensors for monitoring physiological parameters associated with the patient, including one or more of electrocardiogram (ECG) signals, respiration rates, bio-impedance levels, activity level, postures, or temperature.
8. The system of claim 7 , wherein the one or more processors are configured to utilize at least one of the monitored physiological parameters in combination with stored hemoglobin concentration levels to determine a patient condition.
9. The system of claim 1 , wherein the hemoglobin component comprises a first hemoglobin component and the ratio comprises a first ratio, the system further comprising a third photodetector configured to monitor the emission response at a third emission wavelength, wherein the third emission wavelength is selected to correspond with a maximum of the emission response of a second hemoglobin component, and wherein the one or more processors are configured to:
receive the emission response at the third emission wavelength;
calculate a second ratio based on the third emission response; and
determine the hemoglobin concentration level based on a combination of the first ratio and the second ratio.
10. A method of non-invasively monitoring hemoglobin concentration level, the method comprising:
providing incident light to patient tissue at a first excitation wavelength;
monitoring an emission response at a first emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response of a hemoglobin component, wherein the hemoglobin component comprises at least one of oxyhemoglobin or de-oxyhemoglobin;
monitoring the emission response at a second emission wavelength, wherein the second emission wavelength is selected to correspond with a minimum of the emission response of the hemoglobin component; and
calculating the hemoglobin concentration level based on a ratio of the emission response measured at the first emission wavelength to the emission response measured at the second emission wavelength.
11. The method of claim 10 , wherein the hemoglobin component is oxyhemoglobin and the hemoglobin concentration level is an oxyhemoglobin concentration level, wherein the first emission wavelength is selected to correspond with a maximum of an oxyhemoglobin emission response and the second emission wavelength is selected to correspond with a minimum of the oxyhemoglobin emission response.
12. The method of claim 10 , wherein the hemoglobin component is de-oxyhemoglobin and the hemoglobin concentration is a de-oxyhemoglobin concentration, wherein the first emission wavelength is selected to correspond with a maximum of a de-oxyhemoglobin emission response and the second emission wavelength is selected to correspond with a minimum of the de-oxyhemoglobin emission response.
13. The method of claim 10 , further including detecting anemia based on the calculated hemoglobin concentration level falling below a threshold level.
14. The method of claim 10 , wherein the monitoring and calculating a hemoglobin concentration level is performed in real-time or near real-time.
15. The method of claim 10 , further including monitoring physiological parameters associated with the patient, including one or more of electrocardiogram (ECG) signals, respiration rates, bio-impedance levels, activity level, postures, or temperature.
16. The method of claim 15 , further including utilizing at least one of the monitored physiological parameters in combination with stored hemoglobin concentration levels to determine a patient condition.
17. The method of claim 10 , wherein the hemoglobin component comprises a first hemoglobin component and the ratio comprises a first ratio, the method further comprising:
monitoring the emission response at a third emission wavelength, wherein the third emission wavelength is selected to correspond with a maximum of the emission response of a second hemoglobin component; and
calculating a second ratio based on the third emission response; and
wherein calculating the hemoglobin concentration level comprises calculating the hemoglobin concentration level based on a combination of the first ratio and the second ratio.