System and method for non-invasive monitoring of hematocrit concentration
A method of non-invasively monitoring hematocrit levels includes monitoring a first emission response to the light provided at the first excitation wavelength, wherein the first emission response is monitored at a first wavelength and monitoring a second emission response to the light provided at the first excitation wavelength, wherein the second emission response is monitored at a second wavelength. A ratiometric value is calculated based on a ratio of the first emission response to the second emission response, wherein the ratiometric value corresponds with hematocrit level of the patient.
1. A system comprising:
a medical device comprising:
at least one light source configured to provide a first excitation signal to tissue of a patient, the first excitation signal configured to generate a continuous emission response spectrum from the tissue for at least two selected blood components; and
at least one light detector configured to receive the continuous emission response spectrum and detect a first emission response at a first emission wavelength and a second emission response at a second emission wavelength; and
one or more processors configured to:
calculate a ratiometric value based on a first emission response amplitude at the first emission wavelength and a second emission response amplitude at the second emission wavelength, wherein the first emission wavelength is selected to correspond with an isosbestic maximum associated with the at least two selected blood components of the continuous emission response spectrum and the second emission wavelength is selected to correspond with an isosbestic minimum associated with the at least two selected blood components of the continuous emission response spectrum, and the ratiometric value varies based on hematocrit level of the patient;
compare the calculated ratiometric value to a baseline ratiometric value;
determine a hematocrit level based on the comparison of the calculated ratiometric value to the baseline ratiometric value; and
generate an alert of a condition of the patient based on the comparison.
2. The system of claim 1 , wherein the one or more processors are configured to:
output the hematocrit level to a computing device.
3. The system of claim 1 , wherein the baseline ratiometric value corresponds to a known baseline hematocrit level of the patient.
4. The system of claim 1 , wherein the at least two selected blood components comprise oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb).
5. The system of claim 1 , wherein the medical device comprises the one or more processors.
6. The system of claim 1 , further comprising a computing device configured to receive data from the medical device, wherein the computing device comprises the one or more processors.
7. The system of claim 1 , wherein the medical device is an insertable monitoring device configured for subcutaneous insertion in the patient, wherein the medical device comprises a plurality of electrodes.
8. The system of claim 1 , wherein the condition of the patient is anemia.
9. The system of claim 1 , wherein the condition of the patient is heart failure.
10. An insertable monitoring device configured for subcutaneous insertion in a patient, the insertable monitoring device comprising:
communication circuitry configured to wireless communicate with an external computing device;
a plurality of electrodes;
at least one light source configured to provide a first excitation signal to tissue of a patient, the first excitation signal configured to generate a continuous emission response spectrum from the tissue for at least two selected blood components;
at least one light detector configured to receive the continuous emission response spectrum and detect a first emission response at a first emission wavelength and a second emission response at a second emission wavelength; and
one or more processors configured to:
calculate a ratiometric value based on a first emission response amplitude at the first emission wavelength and a second emission response amplitude at the second emission wavelength, wherein the first emission wavelength is selected to correspond with an isosbestic maximum associated with the at least two selected blood components of the continuous emission response spectrum and the second emission wavelength is selected to correspond with an isosbestic minimum associated with the at least two selected blood components of the continuous emission response spectrum, and the ratiometric value varies based on hematocrit level of the patient;
compare the calculated ratiometric value to a baseline ratiometric value;
determine a hematocrit level based on the comparison of the calculated ratiometric value to the baseline ratiometric value; and
control the communication circuitry to transmit an alert of a condition of the patient to the external computing device based on the comparison.
11. The insertable monitoring device of claim 10 , wherein the one or more processors are configured to:
output the hematocrit level to the external computing device.
12. The insertable monitoring device of claim 10 , wherein the baseline ratiometric value corresponds to a known baseline hematocrit level of the patient.
13. The insertable monitoring device of claim 10 , wherein the at least two selected blood components comprise oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb).
14. The insertable monitoring device of claim 10 , wherein the condition of the patient is anemia.
15. The insertable monitoring device of claim 10 , wherein the condition of the patient is heart failure.
16. A method comprising:
providing, by at least one light source of a medical device, a first excitation signal to tissue of a patient, the first excitation signal configured to generate a continuous emission response spectrum from the tissue for at least two selected blood components;
receiving, by at least one light detector of the medical device, the continuous emission response spectrum and detecting a first emission response at a first emission wavelength and a second emission response at a second emission wavelength;
calculating, by one or more processors, a ratiometric value based on a first emission response amplitude at the first emission wavelength and a second emission response amplitude at the second emission wavelength, wherein the first emission wavelength is selected to correspond with an isosbestic maximum associated with the at least two selected blood components of the continuous emission response spectrum and the second emission wavelength is selected to correspond with an isosbestic minimum associated with the at least two selected blood components of the continuous emission response spectrum, and the ratiometric value varies based on hematocrit level of the patient;
comparing, by the one or more processors, the calculated ratiometric value to a baseline ratiometric value;
determining, by the one or more processors, a hematocrit level based on the comparison of the calculated ratiometric value to the baseline ratiometric value; and
generating, by the one or more processors, an alert of a condition of the patient based on the comparison.
17. The method of claim 16 , further comprising outputting, by the one or more processors, the hematocrit level to a computing device.
18. The method of claim 16 , wherein the baseline ratiometric value corresponds to a known baseline hematocrit level of the patient.