Devices and methods for the supplementation of a nutritional formula
Exemplary embodiments of the disclosure may be drawn to a device having a vessel configured to contain a source of lipids and a chamber fluidly connected to an outlet of the vessel. The chamber may contain immobilized lipase positioned within a flow path in the chamber along which the lipids flow when released from the vessel into the chamber. The device may also include an outlet through which the lipids flow after passing through the chamber.
1. A device comprising:
a vessel including a single opening, wherein the vessel houses a source of lipids;
a chamber fluidly and directly connected to the opening of the vessel;
immobilized lipase contained within the chamber and positioned within a flow path in the chamber along which the lipids flow when released from the vessel into the chamber, wherein the opening transitions between retaining or releasing the lipids within the vessel in response to an application of pressure to at least a portion of the device; and
an outlet through which the lipids flow after passing through the chamber.
2. The device of claim 1 , wherein the vessel is removably coupled to the chamber.
3. The device of claim 1 , wherein the vessel is compressible.
4. The device of claim 1 , further comprising a connector fluidly coupled to the outlet, wherein the connector includes:
a first opening for receiving a flow of fluid;
a second opening for outputting the flow of fluid; and
a connector flow path extending through the connector from the first opening to the second opening.
5. The device of claim 4 , further comprising an interface located between the connector and the outlet through which the lipids flow from the outlet and into the connector.
6. The device of claim 5 , wherein the interface is removably connected to the connector.
7. The device of claim 1 , wherein the lipids include two or more different types of lipids.
8. A device comprising:
a vessel having an opening;
a source of lipids contained within the vessel;
wherein the opening is configured to transition from a first configuration in which the source of lipids is retained within the vessel, and a second configuration in which the source of lipids is permitted to flow out of the opening in response to an application of pressure to at least a portion of the device,
a chamber coupled to the opening in the vessel;
an output assembly coupled to the chamber;
a flow path extending from the opening in the vessel, through the chamber, and through the output assembly along which the lipids flow through the device when released from the vessel; and
immobilized lipase contained within the chamber and located within the flow path, wherein the lipase is configured to hydrolyze the lipids as the lipids flow through the chamber.
9. The device of claim 8 , wherein the vessel includes only one opening.
10. The device of claim 8 , wherein the vessel is compressible.
11. The device of claim 8 , wherein the output assembly has a first end and a second end, wherein the first end is coupled to the chamber, and the first end has a width that is greater than a width of the second end.
12. The device of claim 8 , wherein the output assembly has a first end and a second end, wherein the first end is coupled to the chamber, and the second end has an opening that is covered by a seal when the lipids are contained within the vessel and is uncovered by the seal when the lipids are flowing along the flow path.
13. The device of claim 8 , wherein the lipids include two or more different types of lipids.
14. A method of supplementing a nutritional formula with hydrolyzed lipids, the method comprising:
passing a source of lipids stored in a device through a chamber of the device that contains immobilized lipase in order to hydrolyze the lipids by exposing the lipids to the lipase in the chamber, wherein the source of lipids is passed through the chamber in response to an application of pressure to at least a portion of the device;
outputting the hydrolyzed lipids from the chamber of the device; and
adding the hydrolyzed lipids to the nutritional formula;
wherein the nutritional formula is flowed past the device as the hydrolyzed lipids are added to the nutritional formula.
15. The method of claim 14 , further comprising preparing the source of lipids prior to passing the lipids through the chamber.
16. The method of claim 15 , wherein preparing the source of lipids includes mixing at least two different types of lipids together.
17. The method of claim 14 , wherein the source of lipids is stored in a vessel of the device prior to being passed through the chamber, and wherein the method further comprises attaching the vessel to the device prior to passing the source of lipids through the chamber.
18. The method of claim 14 , further comprising attaching the device to a feeding system prior to passing the source of lipids through the chamber.
19. The method of claim 18 , further comprising feeding the nutritional formula to a subject after the hydrolyzed lipids have been added to the nutritional formula.
20. The method of claim 14 , wherein adding the hydrolyzed lipids to the nutritional formula includes outputting the hydrolyzed lipids from the device and into a container containing the nutritional formula.
21. The device of claim 1 , wherein the vessel is compressible, and wherein the opening transitions between retaining or releasing the lipids within the vessel in response to compressing the vessel in which the source of lipids is housed.
22. The device of claim 8 , wherein the vessel is compressible, and wherein the opening transitions from the first configuration to the second configuration in response to compressing the vessel in which the source of lipids is contained.
23. The method of claim 14 , wherein the source of lipids is passed through the chamber in response to compression of the at least a portion of the device.