Transdermal carrier
Improved formulations for topical treatment that ensure at least localized transdermal or systemic delivery of an active agent through skin, nails or hair follicles are disclosed.
1. A method for treating an individual to impede lactic acidosis, wherein the individual is administered a topical formulation for transdermal delivery of an active agent through the skin of a subject,
wherein said active agent comprises sodium bicarbonate,
wherein said formulation comprises a penetrant that provides a lecithin at 5%-15% w/w of said formulation and sodium bicarbonate at 20%-40% w/w of the formulation, wherein said formulation further comprises an isopropyl palmitate, benzyl alcohol at 0.5%-20% w/w of the formulation, propylene glycol at about 1%-5% w/w of the formulation, poloxamer 407 at 1%-15% w/w of the formulation.
2. The method of claim 1 , wherein the topical formulation further comprises sodium lauryl sulfate at 0.5%-2.5% w/w of the formulation.
3. The method of claim 1 , wherein the topical formulation further comprises one or more of ethanol and water.
4. The method of claim 1 , wherein the time for absorption was between 10-15 minutes following application.
5. The method of claim 1 , wherein the topical formulation increased athletic performance by up to 64%.
6. The method of claim 1 , wherein the topical formulation increases the time it takes for an individual to suffer from acidosis burn in the individual undertaking a form of muscle movement.
7. The method of claim 1 , wherein the topical formulation is applied to the individual prior to muscle exertion.
8. The method of claim 1 , wherein the topical formulation further comprises one or more of an electrolyte and readily metabolized nutrients.
9. The method of claim 1 , wherein the topical formulation further comprises one or more of beta-alanine, L-carnitine, adenosine triphosphate, dextrose, creatine monohydrate, beta-hydroxy-beta-methyl butyrate, branched chain amino acids, glutathione, sodium phosphate and caffeine.
10. The method of claim 1 , wherein the topical formulation is applied to the skin of the individual.