Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

1. A process for the preparation of compound (Id) with the formula below

from compound (I) with the formula below

comprising the following step

reacting compound (I), or a salt thereof, with benzyl halogenide to obtain compound (A2) according to the reaction scheme below

wherein Ph is phenyl and X is selected from the group consisting of Cl, Br and I.

2. The process according to claim 1 , wherein:

a) said benzyl halogenide is benzyl chloride and X is Cl; or

b) said benzyl halogenide is benzyl bromide and X is Br.

3. A compound of formula (A2) below:

or a salt thereof.

4. The process according to claim 1 for the preparation of compound (Id) with the formula below

from compound (I) with the formula below

comprising the following step

subjecting compound (A2) to a debenzylation reaction to obtain compound (A3), or a salt thereof according to the reaction scheme below

5. A compound of formula (A3) below:

or a salt thereof.

6. The process according to claim 4 , wherein the debenzylation reaction comprises the steps of:

I) reacting trimethylsilyl iodide with compound (A2) to form a mixture; and

II) adding an alcohol to said mixture from step I) to obtain compound (A3) or a salt thereof; and

III) optionally isolating compound (A3), or a salt thereof as obtained in step (II).

7. The process according to claim 6 , wherein the alcohol added to said mixture in step II) is selected from the group consisting of MeOH, n-heptyl alcohol, and ethanol.

8. The process according to claim 4 , wherein compound (A3) is obtained in the form of a hydroiodide salt with the formula (A3-HI) below

9. The compound according to claim 5 , which is in the form of a hydroiodide salt with the formula (A3-HI) below

10. The process according to claim 1 for the preparation of compound (Id) with the formula below

from compound (I) with the formula below

comprising the following step

reacting compound (A3), or salt thereof, with (2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate to obtain compound (A4) according to the reaction scheme below

11. The process according to claim 10 , wherein compound (A3) is in the form of the hydroiodide salt (A3-HI) with the formula below:

12. A compound of formula (A4) below:

or a salt thereof.

13. A process for the preparation of compound (Id) with the formula below

from compound (I) with the formula below

comprising the following step

reacting compound (A4) with alkali-hydroxide to obtain (A5-Y) according to the reaction scheme below

wherein Y is selected from Li, Na and K.

14. The process according to claim 13 , wherein:

a) said alkali hydroxide is lithium hydroxide and Y is Li; or

b) said alkali hydroxide is sodium hydroxide and Y is Na; or

c) said alkali hydroxide is potassium hydroxide and Y is K.

15. A compound of formula (A5) below:

or a salt thereof.

16. The compound according to claim 15 which is in the form of an alkali salt depicted below

wherein Y is selected from the group consisting of Li, Na and K.

17. The process according to claim 1 for the preparation of compound (Id) with the formula below

from compound (I) with the formula below

comprising the following step

debenzylating compound (A5-Y) to obtain compound (Id) according to the reaction scheme below

wherein Y is selected from the group consisting of Li, Na, and K.

18. The process according to claim 1 for the preparation of compound (Id) from compound (I) comprising

a step reacting compound (I), or a salt thereof, with benzyl halogenide to obtain compound (A2) according to the reaction scheme below

wherein Ph is phenyl and X is selected from the group consisting of Cl, Br and I; followed by

a step subjecting compound (A2) to a debenzylation reaction to obtain compound (A3), or a salt thereof according to the reaction scheme below

followed by

a step reacting compound (A3), or salt thereof, with (2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate to obtain compound (A4) according to the reaction scheme below

followed by

a step reacting compound (A4) with alkali-hydroxide to obtain (A5-Y) according to the reaction scheme below

wherein Y is selected from Li, Na and K; followed by

a step debenzylating compound (A5-Y) to obtain compound (Id) according to the reaction scheme below

wherein Y is selected from the group consisting of Li, Na and K.