Granted Patent
B2
US 12,479,801 · App. 18/359,136 · Granted Nov 25, 2025
Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol
Inventors:
Mikkel Fog Jacobsen (Valby, DK); Martin Juhl (Valby, DK); Frans Dennis Therkelsen (Valby, DK); Tobias Gylling Frihed (Valby, DK)
Assignee:
H. Lundbeck A/S
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Abstract
The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof. Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.
Claims (3)
1 . A compound of formula (A5) below
or a salt thereof.
2 . The compound of claim 1 , which is in the form of a tosylate salt:
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 12, 2025
From: JUHL, MARTIN; JACOBSEN, MIKKEL FOG; FRIHED, TOBIAS GYLLING; THERKELSEN, FRANS DENNIS; SØNDERGAARD, KÅRE
To: H. LUNDBECK A/S
Reel/Frame 070191/0915 →
Priority Claims (1)
DK PA201900600
· May 20, 2019
· national
Continuity (3)
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