Oral care compositions for active agent delivery
An oral care composition with an aqueous phase, hydrophobic phase, active agent, and optionally emulsifier. A jammed emulsion with aqueous phase, hydrophobic phase, active agent, and optionally emulsifier. An oral care composition with aqueous phase, hydrophobic phase, active agent, and optionally emulsifier. Methods of using disclosed compositions for active agent delivery.
1. A jammed oil-in-water emulsion comprising:
(a) from about 1% to about 15%, by weight of the emulsion, of at least partially continuous aqueous phase;
(b) discontinuous hydrophobic phase;
(c) oral care active agent; and
(d) emulsifier;
wherein the emulsifier is hydrophilic, miscible with water, immiscible with oil, or combinations thereof.
2. The jammed oil-in-water emulsion of claim 1 , wherein the emulsifier has a hydrophilic-lipophilic balance of from about 11 to about 60.
3. The jammed oil-in-water emulsion of claim 1 , wherein the jammed oil-in-water emulsion comprises from about 80% to about 99%, by weight of the composition, of the hydrophobic phase.
4. The jammed oil-in-water emulsion of claim 1 , wherein the jammed oil-in-water emulsion comprises from about 5% to about 15%, by weight of the emulsion, of the aqueous phase.
5. The jammed oil-in-water emulsion of claim 1 , wherein the aqueous phase comprises the oral care active agent.
6. The jammed oil-in-water emulsion of claim 1 , wherein the hydrophobic phase comprises the oral care active agent.
7. The jammed oil-in-water emulsion of claim 5 , wherein the oral care active agent comprises bleaching agent, anti-caries agent, anti-tartar agent, remineralization agent, wound healing agent, anti-inflammatory agent, antibacterial agent, metal ion source, anti-glycolytic agent, amino acid, probiotic, prebiotic, postbiotic, polyphosphate, buffer, anti-sensitivity agent, or combinations thereof.
8. The jammed oil-in-water emulsion of claim 7 , wherein the oral care active agent comprises hydrogen peroxide.
9. The jammed oil-in-water emulsion of claim 8 , wherein 35% of the aqueous phase is hydrogen peroxide.
10. The jammed oil-in-water emulsion of claim 1 , wherein the jammed oil-in-water emulsion comprises from about 0.01% to about 10%, by weight of the jammed oil-in-water emulsion, of the emulsifier.
11. The jammed oil-in-water emulsion of claim 1 , wherein the emulsifier comprises a polysorbate, an alkyl sulfate, or combinations thereof.
12. The jammed oil-in-water emulsion of claim 1 , wherein the emulsifier comprises polysorbate 20, polysorbate 40, sodium lauryl sulfate, or combinations thereof.
13. The jammed oil-in-water emulsion of claim 1 , wherein the oral care active agent comprises fluoride ion source, metal ion source, sugar alcohol, bioglass containing compound, amino acid, peptide, or combinations thereof.
14. The jammed oil-in-water emulsion of claim 13 , wherein the fluoride ion source comprises sodium fluoride, potassium fluoride, titanium fluoride, hydrofluoric acid, amine fluoride, sodium monofluorophosphate, stannous fluoride, or combinations thereof.
15. The jammed oil-in-water emulsion of claim 13 , wherein the metal ion source comprises zinc ion source, stannous ion source, copper ion source, or combinations thereof.
16. The jammed oil-in-water emulsion of claim 13 , wherein the amino acid is selected from the group consisting of histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, alanine, asparagine, aspartic acid, glutamic acid, arginine, cysteine, glutamine, tyrosine, glycine, ornithine, proline, serine, calcium salts thereof, and combinations thereof.
17. A method comprising applying the jammed oil-in-water emulsion of claim 1 to at least one tooth of a consumer in a delivery carrier.
18. The method of claim 17 , wherein the delivery carrier is a tray or strip.