N-substituted indoles and other heterocycles for treating brain disorders
View Patent ↗The present invention provides N-substituted indoles and other heterocycles and methods of using the compounds for treating brain disorders.
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
12. A method for treating a brain disorder, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
13. The method of claim 12 , wherein the brain disorder is a psychological disorder, depression, addiction, anxiety, or post-traumatic stress disorder.
14. The method of claim 13 , wherein the brain disorder is depression or addiction.
15. The method of claim 12 , wherein the brain disorder is treatment resistant depression, suicidal ideation, major depressive disorder, bipolar disorder, schizophrenia, or substance use disorder.
16. A pharmaceutical composition, comprising a therapeutically effective amount of a compound selected from claim 1 , or a pharmaceutically acceptable salt thereof.
17. The pharmaceutical composition of claim 16 , selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
18. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
19. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
20. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
21. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
22. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
23. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
24. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
25. The pharmaceutical composition of claim 17 , wherein the compound is
or a pharmaceutically acceptable salt thereof.