Methods of treating feline coronavirus infections
View Patent ↗Provided are methods of treating feline Coronavirus infections using carbanucleoside compounds having a 1′-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl) substituent, or a pharmaceutically acceptable salt thereof. An exemplary compound is (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile.
1. A method of treating a feline Coronavirus infection in a cat in need thereof, comprising administering to the cat a pharmaceutical formulation comprising a compound of formula:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
2. The method of claim 1 , wherein the pharmaceutical formulation comprises a compound of formula:
3. The method of claim 1 , wherein the feline Coronavirus is feline enteric coronavirus (FECV) or feline infectious peritonitis virus (FIPV).
4. The method of claim 3 , wherein the feline Coronavirus is feline enteric coronavirus (FECV).
5. The method of claim 3 , wherein the feline Coronavirus is feline infectious peritonitis virus (FIPV).
6. The method of claim 1 , wherein the cat has tested positive for feline Coronavirus infection.
7. The method of claim 1 , wherein the cat is showing symptoms for feline Coronavirus infection.
8. The method of claim 1 , wherein the administering comprises oral, rectal, nasal, pulmonary, topical, vaginal, or parenteral administration.
9. The method of claim 1 , wherein the administering comprises subcutaneous, intramuscular, intravenous, intradermal, intrathecal, or epidural administration.