Method and apparatus for pain control using baroreflex sensitivity during posture change
An example of a system for providing a patient with pain management includes a pain monitoring circuit. The pain monitoring circuit may include parameter analyzer circuitry and pain score generator circuitry. The parameter analyzer circuitry may be configured to receive and analyze one or more timing parameters and one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient. The one or more timing parameters are indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS. The pain score generator circuitry may be configured to compute a pain score using an outcome of the analysis. The pain score is a function of the BRS during the time intervals and indicative of a degree of pain of the patient.
1. A system for providing a patient with pain management, the system comprising:
a pain monitoring circuit including:
a parameter generator configured to receive a blood pressure signal indicative of a blood pressure of the patient and to generate one or more baroreflex parameters using at least the blood pressure signal, the one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient;
a parameter analyzer configured to receive and analyze one or more timing parameters and the one or more baroreflex parameters, the one or more timing parameters indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS; and
a pain score generator configured to compute a pain score using an outcome of the analysis, the pain score being a function of the BRS during the time intervals and indicative of a degree of pain of the patient;
a pain relief device configured to deliver one or more pain-relief therapies to the patient; and
a control circuit configured to control the delivery of the one or more pain-relief therapies using the computed pain score.
2. The system of claim 1 , wherein the parameter generator is configured to generate the one or more baroreflex parameters including at least one of a blood pressure parameter indicative of the blood pressure, a change in the blood pressure parameter, a slope of the change in the blood pressure parameter, or a measure of a neural activity driven by the blood pressure or the change in the blood pressure.
3. The system of claim 2 , wherein the parameter generator is configured to receive a surrogate signal as the blood pressure signal and to generate the one or more baroreflex parameters using at least the surrogate signal, the surrogate signal indicative of physiological activities of the patient driven by the blood pressure or a change in the blood pressure.
4. The system of claim 3 , further comprising a heart sound sensor configured to sense a heart sound signal as the surrogate signal, the heart sound signal indicative of second heart sounds.
5. The system of claim 2 , further comprising a photoplethysmography (PPG) sensor configured to sense a PPG signal as the surrogate signal, the PPG signal indicative of a pulse transit time.
6. The system of claim 2 , wherein the parameter generator is further configured to receive a cardiac signal indicative of cardiac electrical activities of the patient and to generate the one or more baroreflex parameters using the blood pressure signal and the cardiac signal, the one or more baroreflex parameters further including at least one of a heart rate, a change in the heart rate, a slope of the change in the heart rate, or a heart rate variability.
7. The system of claim 1 , wherein the parameter analyzer is configured to receive and analyze a posture parameter of the one or more timing parameters, the posture parameter indicative of at least one of a type, a magnitude, a duration, a velocity, or an acceleration of a change in a posture of the patient.
8. The system of claim 1 , wherein the parameter analyzer is configured to receive and analyze an activity parameter of the one or more timing parameters, the activity parameter indicative of a level of physical activity of the patient.
9. The system of claim 1 , wherein the parameter analyzer is configured to receive and analyze a respiratory parameter of the one or more timing parameters, the respiratory parameters indicative of respiratory cycles each including an inspiration phase and an expiration phase.
10. A method for managing pain of a patient, comprising:
receiving a blood pressure signal indicative of a blood pressure of the patient;
generating one or more baroreflex parameters using at least the blood pressure signal, the one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient;
receiving one or more timing parameters indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS;
analyzing the one or more baroreflex parameters and the one or more timing parameters;
computing a pain score using an outcome of the analysis, the pain score being a function of the BRS during the time intervals and indicative of a degree of pain of the patient;
delivering one or more pain-relief therapies to the patient from a pain relief device; and
controlling the delivery of the one or more pain-relief therapies using the pain score.
11. The method of claim 10 , wherein generating the one or more baroreflex parameters comprises generating a blood pressure parameter indicative of the blood pressure.
12. The method of claim 10 , wherein generating the one or more baroreflex parameters comprises generating a change in a blood pressure parameter, the blood pressure parameter indicative of the blood pressure.
13. The method of claim 10 , wherein generating the one or more baroreflex parameters comprises generating a slope of change in a blood pressure parameter, the blood pressure parameter indicative of the blood pressure.
14. The method of claim 10 , wherein generating the one or more baroreflex parameters comprises generating a measure of a neural activity driven by the blood pressure or a change in the blood pressure.
15. The method of claim 10 , wherein receiving the blood pressure signal comprises receiving a surrogate signal indicative of physiological activities of the patient driven by the blood pressure or a change in the blood pressure.
16. The method of claim 15 , wherein receiving the surrogate signal comprises receiving at least one of a heart sound signal or a photoplethysmography (PPG) signal, the heart sound signal indicative second heart sounds, the PPG signal indicative of a pulse transit time.
17. The method of claim 10 , further comprising receiving a cardiac signal indicative of cardiac electrical activities of the patient, and wherein generating the one or more baroreflex parameters further comprises generating at least one of a heart rate, a change in the heart rate, a slope of the change in the heart rate, or a heart rate variability using the cardiac signal.
18. The method of claim 10 , wherein receiving the one or more timing parameters comprises receiving at least one of a posture parameter, an activity parameter, or a respiratory parameter of the one or more timing parameters, the posture parameter indicative of at least one of a type, a magnitude, a duration, a velocity, or an acceleration of a change in a posture of the patient, the activity parameter indicative of a level of physical activity of the patient, the respiratory parameters indicative of respiratory cycles each including an inspiration phase and an expiration phase.
19. A non-transitory computer-readable storage medium including instructions, which when executed by a system, cause the system to perform a method for managing pain of a patient, the method comprising:
receiving a blood pressure signal indicative of a blood pressure of the patient;
generating one or more baroreflex parameters using at least the blood pressure signal, the one or more baroreflex parameters allowing for determination of baroreflex sensitivity (BRS) of the patient;
receiving one or more timing parameters indicative of time intervals during which values of the one or more baroreflex parameters are used to determine the BRS;
analyzing the one or more baroreflex parameters and the one or more timing parameters;
computing a pain score using an outcome of the analysis, the pain score being a function of the BRS during the time intervals and indicative of a degree of pain of the patient;
delivering one or more pain-relief therapies to the patient from a pain relief device; and
controlling the delivery of the one or more pain-relief therapies using the pain score.
20. The non-transitory computer-readable storage medium of claim 19 , wherein generating the one or more baroreflex parameters comprises generating at least one of a blood pressure parameter indicative of the blood pressure, a change in the blood pressure parameter, a slope of the change in the blood pressure parameter, or a measure of a neural activity driven by the blood pressure or the change in the blood pressure.