3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor

1. A compound of the formula I:

wherein:

A is selected from: benzofuranone, benzoimidazole, benzoisoxazole, benzothiazole, benzotriazole, benzoxazole, dihydrobenzofuranone, dihydroisoindole, imidazopyridazine, imidazopyridine, indazole, isobenzofuranone, isoindoline, isoindolinone, oxazolopyridine, pyrazolopyridine, pyrrolopyridinone, and triazolopyridine;

R 1 is selected from:

(1) hydrogen,

(2) halogen,

(3) —CN,

(4) —C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro,

(5) —O—C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro,

(6) —C≡CH,

(7) -pyrazolyl,

(8) —(C═O)—NH 2 , and

(9) —(C═O)—NH(—C 1-6 alkyl);

R 2 is selected from:

(1) hydrogen,

(2) halogen,

(3) —C 1-6 alkyl,

(4) —OC 1-6 alkyl, and

(5) —SC 1-6 alkyl;

R 3 is selected from:

(1) hydrogen,

(2) halogen,

(3) —CN,

(4) —C 1-6 alkyl, and

(5) —NH 2 ;

R 4 is selected from:

(1) hydrogen,

(2) —CN,

(3) chloro, and

(4) fluoro;

R 5 is —C 1-6 alkyl, which is unsubstituted or substituted with:

(1) fluoro,

(2) hydroxy,

(3) —CN,

(4) —OC 1-6 alkyl, which is unsubstituted or substituted with —C 1-6 alkyl, hydroxy, methoxy, fluoro, or —C 1-6 alkyl-fluoro,

(5) —C 3-8 cycloalkyl, which is unsubstituted or substituted with —C 1-6 alkyl, hydroxy, methoxy, fluoro, or —C 1-6 alkyl-fluoro,

(6) furanyl, which is unsubstituted or substituted with —C 1-6 alkyl, hydroxy, methoxy, or 1-3 fluoro, and

(7) phenyl, which is unsubstituted or substituted with —C 1-6 alkyl, hydroxy, methoxy, or 1-3 fluoro;

each of R 8 , R 9 and R 10 is independently selected from:

(1) hydrogen,

(2) halogen,

(3) —OH,

(4) —C 1-6 alkyl, which is unsubstituted or substituted with: hydroxy, —OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro; phenyl, which is unsubstituted or substituted with hydroxy, —C 1-6 alkyl or fluoro; or pyridyl, which is unsubstituted or substituted with hydroxy, —C 1-6 alkyl or fluoro,

(5) —OC 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, —OC 1-6 alkyl, cyclopropyl, cyclobutyl, or 1-3 fluoro,

(6) —C 3-6 cyclolkyl, which is unsubstituted or substituted with a hydroxy, methoxy, or 1-3 fluoro,

(7) —NH 2 , —NH(C 1-6 alkyl), or —N(C 1-6 alkyl) 2 , wherein the —C 1-6 alkyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro,

(8) azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, wherein the azetidinyl, pyrrolidinyl, piperidinyl, or piperazinyl, is unsubstituted or substituted with hydroxy, methoxy, or 1-3 fluoro, and

(9) —CN;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 of the formula Ia:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from:

(1) hydrogen,

(2) fluoro,

(3) chloro,

(4) —CN, and

(5) methyl.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is hydrogen, R 3 is hydrogen and R 1 is selected from:

(1) hydrogen,

(2) fluoro,

(3) chloro,

(4) —CN, and

(5) methyl.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is hydrogen.

6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is —C 1-6 alkyl, which is unsubstituted or substituted with fluoro.

7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is selected from:

(1) 2,2-dimethylpropyl,

(2) 2,2-difluorobutyl,

(3) 3-methylbutyl,

(4) 3-fluoro-3-methylbutyl,

(5) neopentyl,

(6) 1-(methylcyclopentyl)methyl,

(7) 1-(fluorocyclopentyl)methyl,

(8) cyclopentyl-3,3,3-trifluoro-2,2-dimethylpropyl,

(9) 1-(cyclohexylmethyl), and

(10) (1-(trifluoromethyl)cyclopropyl)methyl.

8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each of R 8 , R 9 and R 10 is independently selected from:

(1) hydrogen,

(2) halo,

(3) —OH,

(4) —C 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro,

(5) —OC 1-6 alkyl, which is unsubstituted or substituted with a hydroxy, or 1-3 fluoro, and

(6) cyclopropyl.

9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each of R 8 , R 9 and R 10 is independently selected from:

(1) hydrogen,

(2) fluoro,

(3) —CH 3 ,

(4) —CF 3 , and

(5) —OCH 3 , and

(6) cyclopropyl.

10. A compound which is selected from:

5-(1-(2-cyclopropyl-2,2-difluoroethyl)-1H-pyrazol-4-yl)-6-(imidazo[1,2-a]pyridin-7-yl)picolinonitrile;

2-methyl-6-(6-methyl-3-{1-[(1-methylcyclohexyl)methyl]-1H-pyrazol-4-yl}pyridin-2-yl)-2H-indazole;

6-(6-methyl-3-{1-[(1-methylcyclohexyl)methyl]-1H-pyrazol-4-yl}pyridin-2-yl)-1H-indazole;

3-methyl-6-(6-methyl-3-{1-[(1-methylcyclohexyl)methyl]-1H-pyrazol-4-yl}pyridin-2-yl)-1H-indazole;

3-methyl-6-(6-methyl-3-{1-[(1-methylcyclohexyl)methyl]-1H-pyrazol-4-yl}pyridin-2-yl)-3H-imidazo[4,5-b]pyridine;

2-cyclopropyl-6-{6-methyl-3-[1-(2-methylpropyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one;

6-{3-[1-(bicyclo[1.1.1]pent-1-ylmethyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}-2-methyl-2,3-dihydro-1H-isoindol-1-one;

6-{3-[1-(bicyclo[1.1.1]pent-1-ylmethyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one;

6-{3-[1-(3-fluoro-3-methylbutyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}-2-methyl-2,3-dihydro-1H-isoindol-1-one;

6-{3-[1-(3-fluoro-3-methylbutyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one;

6-[3-(1-benzyl-1H-pyrazol-4-yl)-6-methylpyridin-2-yl]-2-(cyclopropylmethyl)-2, 3-dihydro-1H-isoindol-1-one;

6-{3-[1-(bicyclo[2.2.2]oct-1-ylmethyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}-2-(cyclopropylmethyl)-2,3-dihydro-1H-isoindol-1-one;

2-cyclopropyl-6-{3-[1-(2-fluorobenzyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one;

2-(cyclopropylmethyl)-6-(3-{1-[(4,4-difluorocyclohexyl)methyl]-1H-pyrazol-4-yl}-6-methylpyridin-2-yl)-2,3-dihydro-1H-isoindol-1-one;

6-(3-{1-[(4,4-difluoro-1-methylcyclohexyl)methyl]-1H-pyrazol-4-yl}-6-methylpyridin-2-yl)-2-methyl-2,3-dihydro-1H-isoindol-1-one;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-[1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

7-[3-(1-{[1-(2,2-difluoroethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridin-2-yl]-2-methylimidazo[1,2-a]pyridine;

5-[1-(2,2-difluorobutyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

5-(1-{[1-(fluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

5-[1-(2,2-difluoropropyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

5-[1-(2,2-difluoro-3-methylbutyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-[1-(2,2,3,3-tetrafluoropropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-[1-(2,2,3,3,4,4-hexafluorobutyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

5-[1-(2,2,3,3,4,4,4-heptafluorobutyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

6-imidazo[1,2-a]pyridin-7-yl-5-(1-{[(1 S,2S)-2-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridine-2-carbonitrile;

7-{6-methyl-3-[1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridin-2-yl}imidazo[1,2-a]pyridine;

5-[1-(3,3-difluorobutyl)-1H-pyrazol-4-yl]-6-(1,2-dimethyl-1H-benzimidazol-5-yl)pyridine-2-carbonitrile;

5-[1-(3,3-difluoro-2,2-dimethylbutyl)-1H-pyrazol-4-yl]-6-(1,2-dimethyl-1H-benzimidazol-5-yl)pyridine-2-carbonitrile;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-[1-(3,3,4,4,4-pentafluorobutyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-(1,2-dimethyl-1H-benzimidazol-5-yl)-5-[1-(3,3,4,4-tetrafluorobutyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-[1-(2,2-difluoropropyl)-1H-pyrazol-4-yl]-6-(1,2-dimethyl-1H-benzimidazol-5-yl)pyridine-2-carbonitrile;

6-(1,2-dimethyl-1H-benzimidazol-5-yl)-5-[1-(2,3,3-trifluorobutyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-(1,2-dimethyl-1H-benzimidazol-5-yl)-5-[1-(2,3,3-trifluoro-2-methylbutyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-[1-(4,4-difluoro-2,2-dimethylbutyl)-1H-pyrazol-4-yl]-6-(1,2-dimethyl-1H-benzimidazol-5-yl)pyridine-2-carbonitrile;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-(1-{[1-(2-methylpropyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridine-2-carbonitrile;

6-imidazo[1,2-a]pyridin-7-yl-5-(1-{[1-(1-methylethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridine-2-carbonitrile;

5-{1-[(1-ethylcyclopropyl)methyl]-1H-pyrazol-4-yl}-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

6-(1-methyl-1H-benzimidazol-5-yl)-5-{1-[(4-methyltetrahydro-2H-pyran-4-yl)methyl]-1H-pyrazol-4-yl}pyridine-2-carbonitrile;

6-(2-methylimidazo[1,2-b]pyridazin-7-yl)-5-[1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-[1-(3,3,3-trifluoropropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-[1-(2,3,3,3-tetrafluoropropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-imidazo[1,2-a]pyridin-7-yl-5-[1-(2,2,3,3,3-pentafluoropropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-[1-(4,4,4-trifluoro-3-hydroxybutyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-(imidazo[1,2-a]pyridin-7-yl)-5-(1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl)picolinonitrile;

5-[1-(2-cyclopropylethyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

5-[1-(2-cyano-2-methylpropyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

5-[1-(3-fluoro-3-methylbutyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

5-[1-(3-cyano-3-methylbutyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

5-{1-[(1-methylcyclopropyl)methyl]-1H-pyrazol-4-yl}-6-(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridine-2-carbonitrile;

6-imidazo[1,2-a]pyridin-7-yl-5-[1-(spiro[2.2]pent-1-ylmethyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

6-(2-methyl-3-oxoisoindolin-5-yl)-5-(1-((1-(trifluoromethyl)cyclopropyl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

7-(5,6-difluoro-3-(1-((1-(trifluoromethyl)cyclopropyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)imidazo[1,2-a]pyridine;

3-fluoro-6-(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-5-yl)-5-(1-{[1-(trifluoromethyl)-cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridine-2-carbonitrile;

6-(2-methyl-1,3-benzoxazol-5-yl)-5-(1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridine-2-carbonitrile;

6-imidazo[1,2-a]pyridin-7-yl-5-(1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridine-2-carbonitrile;

7-[5-chloro-3-(1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridin-2-yl]imidazo[1,2-a]pyridine;

5-(1-{[1-(difluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

7-[6-chloro-3-(1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridin-2-yl]imidazo[1,2-a]pyridine

7-[6-chloro-5-methyl-3-(1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridin-2-yl]imidazo[1,2-a]pyridine;

543-(14(3,3-difluorocyclobutyl)methyl)-1H-pyrazol-4-yl)-5-fluoropyridin-2-yl)-1,2-dimethyl-1H-benzo[d]imidazole;

5-(1-{[1-(1,1-difluoroethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)-6-(1,2-dimethyl-1H-benzimidazol-5-yl)pyridine-2-carbonitrile;

6-(2-methyl-[1,2,4]triazolo[1, 5-a]pyridin-7-yl)-5-(1-neopentyl-1H-pyrazol-4-yl)picolinonitrile;

6-[2-(difluoromethyl)imidazo[1,2-a]pyridin-7-yl]-5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(6-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-7-yl]pyridine-2-carbonitrile;

6-(2-chloroimidazo[1,2-a]pyridin-7-yl)-5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(1-methyl-1H-benzotriazol-5-yl)pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(2-methyl-2H-benzotriazol-5-yl)pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(3-methyl [1,2,4]triazolo[4,3-a]pyridin-7-yl)pyridine-2-carbonitrile;

7-{3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}[1,2,4]triazolo[4,3-a]pyridine

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-[1,2,4]triazolo[1, 5-a]pyridin-7-ylpyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-[2-(hydroxymethyl)[1,2,4]triazolo[1,5-a]pyridin-7-yl]pyridine-2-carbonitrile;

6-{3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one;

5-{6-methyl-3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindole tert-butyl 5-{6-methyl-3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-1,3-dihydro-2H-isoindole-2-carboxylate 6-{5-chloro-3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2-methyl-2H-indazole;

5-{5-chloro-3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-1,3-benzothiazole;

6-(1H-benzotriazol-6-yl)-5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

7-{3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-5-fluoropyridin-2-yl}imidazo[1,2-a]pyridine;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(3-fluoroimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

7-{3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(trifluoromethyl)pyridin-2-yl}imidazo[1,2-a]pyridine

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-[1,2,3 ]triazolo[1, 5-a]pyridin-6-ylpyridine-2-carbonitrile;

7-{3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-methoxypyridin-2-yl}-2-methylimidazo[1,2-a]pyridine;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(2-methylpyrazolo[1, 5-a]pyridin-6-yl)pyridine-2-carbonitrile;

7-{3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2-methylimidazo[1,2-a]pyridine

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-b]pyridazin-7-yl)pyridine-2-carbonitrile;

6-(2,3-dimethyl-3H-imidazo[4, 5-b]pyridin-6-yl)-5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-[1-(2-hydroxy-3-methylbutyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

5-[1-(2,2-dimethylbutyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

6-imidazo[1,2-a]pyridin-7-yl-5-[1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

6-imidazo[1,2-a]pyridin-7-yl-5-{1-[(1-methylcyclobutyl)methyl]-1H-pyrazol-4-yl}pyridine-2-carbonitrile;

7-{3-[5-fluoro-1-(3-methylbutyl)-1H-pyrazol-4-yl]-6-methylpyridin-2-yl}imidazo[1,2-a]pyridine;

2-cyclopropyl-6-{6-methyl-3-[1-(2-methylpropyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one;

5-[1-(3,3-difluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-5-yl)pyridine-2-carbonitrile;

7-{6-(difluoromethyl)-3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridin-2-yl}imidazo[1,2-a]pyridine;

7-{6-cyclopropyl-3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridin-2-yl}imidazo[1,2-a]pyridine;

7-{3-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-(trifluoromethoxy)pyridin-2-yl}imidazo[1,2-a]pyridine;

6-(2-methyl [1,2,4]triazolo[1,5-a]pyridin-7-yl)-5-[1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl]pyridine-2-carbonitrile;

5-{3-[1-(3,3-difluoro-2,2-dimethylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-1,2-dimethyl-1H-benzimidazole;

5-(3-(1-(3,3-difluoro-2,2-dimethylbutyl)-1H-pyrazol-4-yl)-5-fluoropyridin-2-yl)-1,2-dimethyl-1H-benzo[d]imidazole;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-[2-(methoxymethyl)imidazo[yl]pyridine-2-carbonitrile;

5-[1-(2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-[2-(methoxymethyl)[1,2,4]triazolo[1,5-a]pyridin-7-yl]pyridine-2-carbonitrile;

7-{3-[1-(3,3-difluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl]-5-fluoropyridin-2-yl}-2-methylimidazo[1,2-a]pyridine;

5-[1-(3,3-difluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

6-(imidazo[1,2-a]pyridin-7-yl)-5-(1-((3-methyltetrahydrofuran-3-yl)methyl)-1H-pyrazol-4-yl)picolinonitrile;

7-(3-{1-[(2,2-dimethylcyclopropyl)methyl]-1H-pyrazol-4-yl}-6-methylpyridin-2-yl)imidazo[1,2-a]pyridine;

6-(6-chloro-3-(1-isopentyl-1H-pyrazol-4-yl)pyridin-2-yl)isoindolin-1-one;

6-chloro-3-(1-isopentyl-1H-pyrazol-4-yl)-2-(3-oxo-2-(2,2,2-trifluoroethyl)isoindolin-5-yl)pyridin-1-ium;

6-{6-chloro-3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one;

6-{6-chloro-3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2-(2-fluorobenzyl)-2,3-dihydro-1H-isoindol-1-one;

6-{6-chloro-3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2-(4-hydroxybenzyl)-2, 3-dihydro-1H-isoindol-1-one;

6-{6-chloro-3-[1-(cyclohexylmethyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2-methyl-2,3-dihydro-1H-isoindol-1-one;

2-cyclobutyl-6-{3-[1-(3-methylbutyl)-1H-pyrazol-4-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one;

6-(3-chloroimidazo[1,2-a]pyridin-7-yl)-5-(1-neopentyl-1H-pyrazol-4-yl)picolinonitrile;

5-(1-((1-fluorocyclobutyl)methyl)-1H-pyrazol-4-yl)-6-(2-methylimidazo[1,2-a]pyridin-7-yl)picolinonitrile;

5-[1-(3-fluoro-3-methylbutyl)-1H-pyrazol-4-yl]-6-(2-methylimidazo[1,2-a]pyridin-7-yl)pyridine-2-carbonitrile;

5-(5-fluoro-3-(1-(3-fluoro-3-methylbutyl)-1H-pyrazol-4-yl)pyridin-2-yl)-1,2-dimethyl-1H-benzo[d]imidazole;

5-(1-(2-fluoro-2-methylpropyl)-1H-pyrazol-4-yl)-6-(imidazo[1,2-a]pyridin-7-yl)picolinonitrile;

5-(1-(2-fluoro-2-methylpropyl)-1H-pyrazol-4-yl)-6-(2-methylimidazo[1,2-a]pyridin-7-yl)picolinonitrile;

7-(6-ethynyl-3-(1-neopentyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-methylimidazo[1,2-a]pyridine

5-(1-(2-cyclopropyl-2-fluoroethyl)-1H-pyrazol-4-yl)-6-(imidazo[1,2-a]pyridin-7-yl)picolinonitrile;

6-(2-methylimidazo[1,2-a]pyridin-7-yl)-5-(1-(3,3,3-trifluoro-2-methylpropyl)-1H-pyrazol-4-yl)picolinonitrile;

6-(2-methylimidazo [1,2-a]pyridin-7-yl)-5-(1-(3,3,3-trifluoro-2-methylpropyl)-1H-pyrazol-4-yl)picolinonitrile;

5-(1-(3-hydroxy-2,2-dimethylpropyl)-1H-pyrazol-4-yl)-6-(2-methylimidazo[1,2-a]pyridin-7-yl)picolinonitrile;

5-(1-(((1s,3s)-1,3-difluorocyclobutyl)methyl)-1H-pyrazol-4-yl)-6-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)picolinonitrile;

5-(1-(((1r,3r)-1,3-difluorocyclobutyl)methyl)-1H-pyrazol-4-yl)-6-(1,2-dimethyl-1H-benzo[d]imidazol-5-yl)picolinonitrile;

2-methyl-7-(3-(1-((1,3,3-trifluorocyclobutyl)methyl)-1H-pyrazol-4-yl)pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyridine

5-(5-fluoro-6-methyl-3-(1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl)pyridin-2-yl)-1,2-dimethyl-1H-benzo[d]imidazole;

6-(imidazo[1,2-a]pyridin-7-yl)-5-(1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl)picolinamide;

7-(6-bromo-3-(1-(3,3,3-trifluoro-2,2-dimethylpropyl)-1H-pyrazol-4-yl)pyridin-2-yl)-2-methyl-[1,2,4]triazolo[1,5-a]pyridine;

5-(1-((2,2-difluoro-1-methylcyclopropyl)methyl)-1H-pyrazol-4-yl)-6-(imidazo[1,2-a]pyridin-7-yl)picolinonitrile;

5-[1-(2,2-dimethylpropyl)-5-fluoro-1H-pyrazol-4-yl]-6-imidazo[1,2-a]pyridin-7-ylpyridine-2-carbonitrile;

4-(2-imidazo[1,2-a]pyridin-7-yl-6-methylpyridin-3-yl)-1-(3-methylbutyl)-1H-pyrazole-5-carbonitrile;

6-(3-(1-isopentyl-1H-pyrazol-4-yl)-5-(methylthio)pyridin-2-yl)isoindolin-1-one;

6-imidazo [1,2-a]pyridin-7-yl-3-methyl-5-(1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridine-2-carbonitrile; and

7-[5,6-dimethyl-3-(1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-pyrazol-4-yl)pyridin-2-yl]imidazo[1,2-a]pyridine;

or a pharmaceutically acceptable salt thereof.

11. A method for the treatment of schizophrenia comprising the step of administering at least one compound of claim 1 , or a pharmaceutically acceptable salt of said compound, to a patient in need thereof in an amount effective to treat said disorder.