IP Library Granted Patent US 11,510,410
Granted Patent B2
US 11,510,410 · App. 16/366,573 · Granted Nov 29, 2022

Pediculicidal composition

Inventors: Ronald Harding (Warrandyte, AU); Lewis David Schulz (Fitzroy North, AU); Vernon Morrison Bowles (Glen Iris, AU)
A01N43/40A01N25/30
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Quick Facts
Patent No.
US 11,510,410
App. No.
16/366,573
Granted
Nov 29, 2022
Kind
B2
Abstract

The disclosure provides a pediculicidal composition comprising a metal chelating agent; a carrier vehicle comprising water and an activating solvent system comprising an alcohol and a hydrocarbon. The carrier vehicle may be in the form of a solution, a cream, an ointment, a foam, a spray, an emulsion or a gel. The disclosure also provides method for use of a pediculicidal composition to treat human head lice and their eggs and methods for controlling head lice infestation.

Claims (32)

1. A composition comprising:

5,5′-dimethyl-2,2′-dipyridyl; and

a carrier vehicle comprising water and an activating solvent system comprising an alcohol and a hydrocarbon;

wherein the alcohol is benzyl alcohol in an amount from about 0.5% to about 10% by weight and the hydrocarbon is mineral oil in an amount from about 2% to about 35% by weight, and wherein the said alcohol and hydrocarbon act solely as an activating solvent system;

wherein 5,5′-dimethyl-2,2′-dipyridyl is present in the composition at a concentration from about 0.25% by weight or greater, and wherein said composition exhibits both ovicidal and lousicidal activity.

2. A composition comprising:

5,5′-dimethyl-2,2′-dipyridyl in an amount from about 0.25% to about 5% by weight;

and an activating solvent system comprising:

benzyl alcohol in an amount from about 0.5% to about 10% by weight;

mineral oil in an amount from about 2% to about 35% by weight;

water in an amount from about 35% to about 95% by weight;

an alkyl acrylate crosspolymer in an amount from about 0.1% to about 1% by weight;

trolamine in an amount from about 0.1% to about 2% by weight;

butylated hydroxy toluene from about 0.1% to about 1.5% by weight; and

polysorbate 20 in an amount from about 0.1% to about 5% by weight.

3. The composition of claim 1 , wherein said alcohol further comprises an additional aromatic alcohol or an aryl alcohol.

4. The composition of claim 3 , wherein said additional aromatic or aryl alcohol comprises phenoxyethanol.

5. The composition of claim 1 , wherein 5,5′-dimethyl-2,2′-dipyridyl is present in the composition at a concentration from about 0.25% to about 5% by weight.

6. The composition of claim 1 , wherein 5,5′-dimethyl-2,2′-dipyridyl is present in the composition at a concentration from about 0.5% to about 5% by weight.

7. The composition of claim 1 , wherein 5,5′-dimethyl-2,2′-dipyridyl is present in the composition at a concentration from about 0.5% to about 1% by weight.

8. The composition of claim 1 , wherein said carrier vehicle is a solution, a gel, a cream, an ointment, a foam, a spray or an emulsion.

9. A composition comprising:

a) 5,5′-dimethyl-2,2′-dipyridyl in an amount from about 0.25% to about 5% by weight;

b) an activating solvent system comprising:

i) a solvent at a concentration of from about 0.5% w/w to about 35% w/w, and

ii) a cosolvent at a concentration of from about 2% w/w to about 50% w/w;

c) a thickening agent; and

wherein the 5,5′-dimethyl-2,2′-dipyridyl is solubilized in the activating solvent system and exhibits both ovicidal and lousicidal activity.

10. The composition of claim 9 , wherein said thickening agent is selected from the group consisting of acritamers, alkyl acrylate crosspolymer or copolymers of acrylic acid and C10-C30 alkyl acrylate.

11. The composition of claim 9 , wherein said thickening agent is selected from the group consisting of: agar, acritamers, alkyl acrylate crosspolymer, copolymers of acrylic acid and C10-C30 alkyl acrylate or an amine salt, ammonium salt, sodium salt, potassium salt thereof, propylene glycol alginate, chitosan, hydroxyethyl cellulose, hydroxyethyl methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, sodium carboxymethylcellulose, dextrin, gelatin, acacia, ceratonia , guar, tragacanth, xanthan gum, hydroxypropyl guar, guar hydroxypropyltrimonium chloride, maltodextrin, pectin, polycarbophil, polydextrose, PEG 200, PEG 300, PEG 400, PEG 540, PEG 600, PEG 900, PEG 1000, PEG 1450, PEG 1500, PEG 1540, PEG 2000, PEG 3000, PEG 3350, PEG 4000, PEG 4600, PEG 6000, PEG 8000, PEG 20000, PEG 35000, polyethylene oxide, poly(methyl vinyl ether/maleic anhydride) and copolymers and derivatives thereof, polyvinyl alcohol, PVP K12, PVP K15, PVP K17, PVP K25, PVP K30, PVP K60, PVP K90, PVP K120, pregelatinized starch, hyaluronic acid, sodium hyaluronate, sulfobutylether beta-cyclodextrin, trehalose and mixtures thereof.

12. The composition of claim 9 , wherein the thickening agent is present at a concentration of from about 0.01% wt/wt to about 2% wt/wt.

13. The composition of claim 9 , wherein said thickening agent is an alkyl acrylate crosspolymer.

Assignments (5)
SECURITY INTEREST Recorded Jan 30, 2026
From: CHANNEL PHARMACEUTICAL CORPORATION; PELTHOS THERAPEUTICS INC.
To: HORIZON TECHNOLOGY FINANCE CORPORATION
Reel/Frame 073644/0472 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2026
From: HATCHTECH PTY LTD
To: PELTHOS THERAPEUTICS INC.
Reel/Frame 074394/0060 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2022
From: HATCHTECH PTY LIMITED
To: DR. REDDY'S LABORATORIES, S.A.
Reel/Frame 060289/0098 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2022
From: DR. REDDY'S LABORATORIES, S.A.
To: HATCHTECH PTY LIMITED
Reel/Frame 060289/0287 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2022
From: HARDING, RONALD; SCHULZ, LEWIS DAVID; BOWLES, VERNON MORRISON
To: HATCHTECH PTY LIMITED
Reel/Frame 061043/0088 →
Continuity (3)
Continuation 14573079 · Dec 17, 2014
Provisional Application 61917078 · Dec 17, 2013
Related Publication 20190216086A1 · Jul 18, 2019