Compositions and methods for prevention and treatment of corneal haze and scarring
View Patent ↗This application discloses ophthalmic formulations and methods for treating and preventing corneal haze and scarring with an hepatocyte growth factor (HGF) agent.
1. A method of treating corneal haze or scarring comprising administering a composition comprising purified hepatocyte growth factor (HGF) polypeptide, wherein the HGF polypeptide comprises an amino acid sequence having at least 95% sequence identity to SEQ ID NO: 1, to a subject in need thereof, where the composition is topically administered to the cornea and the corneal haze or scarring is reduced in severity.
2. The method of claim 1 wherein the HGF polypeptide comprises an amino acid sequence having at least 98% sequence identity to SEQ ID NO: 1.
3. The method of claim 1 wherein the HGF polypeptide comprises an amino acid sequence having at least 99% sequence identity to SEQ ID NO: 1.
4. The method of claim 1 , wherein the purified HGF agent is present in a concentration of 0.001% to 1% w/v.
5. The method of claim 1 , wherein the HGF polypeptide is present in a concentration of about 0.005% to 0.5% w/v.
6. The method of claim 1 , wherein the HGF polypeptide is present in a concentration of about 0.01% w/v.
7. The method of claim 1 , wherein the composition is administered daily for 5 days after an injury to the cornea.
8. The method of claim 1 , wherein the composition is administered daily for 3 days after an injury to the cornea.
9. The method of claim 1 , wherein the composition is administered 1 day after an injury to the cornea.
10. The method of claim 1 , wherein the composition is formulated as an eye drop.