IP Library › Granted Patent US 11,759,579
Granted Patent B2
US 11,759,579 · App. 16/696,738 · Granted Sep 19, 2023

Delivery system

Inventors: James J. Yoo (Winston-Salem, NC); Anthony Atala (Winston-Salem, NC); Kyle W. Binder (Winston-Salem, NC); Mohammad Z. Albanna (Winston-Salem, NC); Weixin Zhao (Winston-Salem, NC); Dennis Dice (Yadkinville, NC); Tao Xu (El Paso, TX)
Assignee: Wake Forest University Health Sciences
A61M11/00A61B5/0064A61B5/1077A61B5/1079A61B5/445A61B5/6835A61L27/225A61L27/24A61L27/3813A61L27/60A61M35/20C12N5/0656A61B34/30A61B90/50A61B2017/00969A61B2017/3225A61B2034/105B41J3/4073
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Quick Facts
Patent No.
US 11,759,579
App. No.
16/696,738
Granted
Sep 19, 2023
Kind
B2
Abstract

Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.

Claims (37)

1. A computer program product for processing data of an area of interest of a patient that is obtained from a three-dimensional optical detector comprising a depth detector and a three-dimensional scanner to provide a path to a dispenser operatively coupled to the three-dimensional optical detector, the computer program product comprising a non-transitory computer readable medium having computer readable program code embodied therein, the computer readable program code comprising:

computer readable program code that interprets data that is provided by the optical detector to form a map of the area of interest of the patient;

computer readable program code that transforms the map into a negative mold of the area of interest, wherein the mold comprises a plurality of Z-axis layers;

computer readable program code that overlays each of the Z-axis layers with a series of lines, wherein the lines provide the path for the dispenser to deliver cells and/or compositions to the area of interest; and

computer readable program code that adjusts the path for the dispenser based on movement of the patient that is detected by the depth detector.

2. The computer program product of claim 1 , wherein the cells are selected from the group consisting of cartilage cells, bone cells, muscle cells, vascular cells, skin cells, and combinations thereof.

3. The computer program product of claim 1 , wherein the area of interest is a closed wound.

4. The computer program product of claim 1 , wherein the area of interest comprises an injury or disease of the patient.

5. The computer program product of claim 1 , wherein the data from the optical detector is represented as an object including the Z-axis layers, and

wherein each of the Z-axis layers are represented by a grid that comprises the lines.

6. The computer program product of claim 5 , wherein the computer readable program code is further configured to direct the dispenser to deliver the cells and/or the compositions to a first location of the area of interest that is associated with a first piece of the grid while analyzing a second piece of the grid.

7. The computer program product of claim 5 , further comprising computer readable program code that parses the object in a manner that incorporates locations of different ones of the cells and/or the compositions to be delivered by the dispenser.

8. The computer program product of claim 1 , wherein the computer readable program code is further configured to control a surgical device to provide the optical detector and/or the dispenser with access to the area of interest.

9. The computer program product of claim 8 , wherein the surgical device is an endoscopic device.

10. The computer program product of claim 1 , wherein the Z-axis layers correspond to one or more tissue layers.

11. The computer program product of claim 1 , wherein the computer readable program code is further configured to calibrate the depth detector based on the area of interest and/or a body type of the patient.

12. The computer program product of claim 1 , wherein the computer readable program code is further configured to control a three-dimensional plotter that is operatively associated with the optical detector to position the dispenser.

13. A method of treating an area of interest of a patient, comprising:

scanning the area of interest with an optical detector to obtain three-dimensional coordinates thereof, wherein the optical detector comprises a three-dimensional scanner;

processing the three-dimensional coordinates by:

interpreting data from the optical detector to form a map of the area of interest;

transforming the map into a negative mold of the area of interest, wherein the mold comprises a plurality of Z-axis layers; and

overlaying each of the Z-axis layers with a series of lines, wherein the lines provide a path for a dispenser to deliver cells and/or compositions to the area of interest;

controlling the dispenser to deliver the cells and/or the compositions to the area of interest based on the path; and

adjusting the path for the dispenser based on movement of the patient that is detected by a depth detector that is operatively associated with the optical detector.

14. The method of claim 13 , wherein the cells are selected from the group consisting of cartilage cells, bone cells, muscle cells, vascular cells, skin cells, and combinations thereof.

15. The method of claim 13 , wherein the area of interest is a closed wound.

16. The method of claim 13 , wherein the area of interest is comprises an injury or disease of the patient.

17. The method of claim 13 , wherein the data from the optical detector is represented as an object including the Z-axis layers, and

wherein each of the Z-axis layers are represented by a grid that comprises the lines.

18. The method of claim 17 , wherein the method further comprises controlling the dispenser to deliver the cells and/or the compositions to a first location of the area of interest that is associated with a first piece of the grid while analyzing a second piece of the grid.

19. The method of claim 17 , wherein the method further comprises parsing the object in a manner that incorporates locations of different ones of the cells and/or the compositions to be delivered by the dispenser.

20. The method of claim 13 , wherein the method further comprises controlling a surgical device to provide the optical detector and/or the dispenser with access to the area of interest.

21. The method of claim 20 , wherein the surgical device is an endoscopic device.

22. The method of claim 13 , wherein the Z-axis layers correspond to one or more tissue layers.

23. The method of claim 13 , wherein the method further comprises calibrating the depth detector based on the area of interest and/or a body type of the patient.

24. The method of claim 13 , wherein the method further comprises controlling a three-dimensional plotter that is operatively associated with the optical detector to position the dispenser.

Continuity (6)
Continuation 16158808 · Oct 12, 2018
Division 14019714 · Sep 6, 2013
Continuation PCTUS2012027731 · Mar 5, 2012
Provisional Application 61507416 · Jul 13, 2011
Provisional Application 61450021 · Mar 7, 2011
Related Publication 20200238024A1 · Jul 30, 2020
Cited By (1)
US 12,268,467