Hydrophobically modified chitosan compositions
Disclosed herein is a polymer composition comprising an effective amount of a hydrophobically-modified polymer having functional groups along the backbone occupied by a fatty anhydride moiety. The polymer composition has a potent hemostatic action by gelling blood upon contact, and is suitable for treating internal and external bleeds. As disclosed herein, the modified polymer can be generated without the use of toxic reagents that would require removal from the product. Further, compositions are shelf stable even in a flowable form. That is, the hydrophobic grafts are not lost under product storage conditions (e.g., room temperature storage).
1. A method for treating a wound in a patient, comprising, applying a polymer composition comprising an effective amount of a hydrophobically-modified chitosan having hydrocarbon groups attached to the chitosan backbone through amide linkages to a wound, wherein the composition is formulated with a pH of about 5 or less, wherein the hydrocarbon groups comprise C8 to C18 hydrocarbon groups in an effective amount to form an artificial clot in the presence of blood.
2. The method of claim 1 , wherein the polymer composition is a gel.
3. The method of claim 1 , wherein the polymer composition is a lyophilized sponge.
4. The method of claim 1 , wherein the polymer composition is a film.
5. The method of claim 1 , wherein the polymer composition is a powder.
6. The method of claim 1 , wherein the polymer composition is a foam.
7. The method of claim 1 , wherein the polymer composition is a putty.
8. The method of claim 1 , wherein the hydrophobically-modified chitosan has about 1% to about 10% of available amines substituted with a hydrocarbon group.
9. The method of claim 8 , wherein the hydrophobically-modified chitosan has less than about 3% of available amines substituted with a hydrocarbon group.
10. The method of claim 9 , wherein at least one hydrocarbon group is a linear C14, C16, or C18 hydrocarbon moiety.
11. The method of claim 10 , wherein the chitosan has an average molecular weight of from about 40,000 to about 500,000 Daltons.
12. The method of claim 8 , wherein the hydrophobically-modified chitosan has 2 or 3 different hydrocarbon groups conjugated along the chitosan backbone.
13. The method of claim 12 , having a population of C6 to C12 hydrocarbon groups, and a population of C14 to C18 hydrocarbon groups.
14. The method of claim 13 , wherein the hydrophobic groups further comprise C1 to C4 hydrocarbon groups.
15. The method of claim 1 , wherein the composition is formulated in a dilute organic acid, the organic acid having a pKa of from about 2 to about 5.
16. The method of claim 15 , wherein the organic acid is lactic acid, acetic acid, formic acid, or malic acid.
17. The method of claim 15 , wherein the hydrophobically-modified chitosan is present at 0.1 to about 5% by weight.
18. The method of claim 15 , wherein the organic acid is present in the composition from about 0.05M to 0.4M.
19. The method of claim 1 , wherein the composition further comprises at least one synthetic polymer.
20. The method of claim 19 , wherein the synthetic polymer is a polythene, polystyrene, polyacrylate, polyamide, polyester, polyurethane, polysulfide, or polycarbonate.
21. The method of claim 19 , wherein the synthetic polymer is a polyethylene glycol.
22. The method of claim 1 , wherein the wound has high exudate or blood flow.
23. The method of claim 1 , wherein the wound is selected from a pressure sore, diabetic ulcer, leg ulcer, donor site, graft site, surgical wound, skin abrasion or laceration, 1 st or 2 nd degree burn, and trauma wound.