Antimicrobial coatings
Described are coatings for medical devices and methods of forming same.
1. An antimicrobial coating formulation, comprising:
a base coat comprising a copolymer of tetrahydrofurfuryl acrylate and a monomer comprising a functional group amenable to further derivatization, wherein the copolymer is further modified to contain a plurality of reactive moieties; and
a top coat comprising at least one antimicrobial compound, a polymer, or a combination thereof, wherein the top coat comprises a copolymer reaction product of a mixture comprising [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide and 4-hydroxybutyl acrylate, and the top coat comprises a decorated top coat formed from a reaction product of a mixture comprising the co-polymer reaction product and 2-isocyanatoethyl acrylate.
2. The antimicrobial coating formulation of claim 1 , wherein the top coat comprises a top coat macromer formed from a reaction product of a mixture comprising the decorated top coat, benzophenone, and 1-hydroxycyclohexyl phenyl ketone.
3. The antimicrobial coating formulation of claim 1 , wherein the base coat comprises a copolymer of tetrahydrofurfuryl acrylate and 4-hydroxybuyl acrylate.
4. The antimicrobial coating formulation of claim 3 , wherein the base coat comprises a reaction product of a mixture comprising the copolymer, benzophenone, and 1-hydroxycyclohexyl phenyl ketone.
5. The antimicrobial coating formulation of claim 1 , wherein said functional group comprises at least one of hydroxyl, amine, or carboxylic acid group.
6. The antimicrobial coating formulation of claim 1 , wherein said monomer comprises hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, hydroxybutyl acrylate, hydroxybutyl methacrylate, N-(3-aminopropyl) methacrylamide, 2-aminoethyl methacrylate, 2-aminoethyl methacrylamide, acrylic acid, methacrylic acid, beta-carboxyethyl acrylate, or a combination thereof.
7. The antimicrobial coating formulation of claim 1 , wherein said antimicrobial compound comprises an anti-microbial small molecule, protein, polysaccharide, glycosaminoglycan, or polymer derivatized with polymerizable groups.
8. The antimicrobial coating formulation of claim 1 , wherein said antimicrobial compound comprises at least one of silver-containing polymers, antibiotics, antimicrobial peptides, zwitterionic polymers, nitric oxide releasing polymers, enzymes, extremely hydrophilic polymers, and extremely hydrophobic polymers.
9. The antimicrobial coating formulation of claim 1 , wherein the structure of said top coat is linear or branched.
10. A catheter, comprising a surface including the antimicrobial coating formulation of claim 1 .
11. A catheter, comprising a surface including the antimicrobial coating formulation of claim 2 .
12. A catheter, comprising a surface including the antimicrobial coating formulation of claim 3 .
13. A catheter, comprising a surface including the antimicrobial coating formulation of claim 4 .
14. A catheter, comprising a surface including the antimicrobial coating formulation of claim 5 .
15. A catheter, comprising a surface including the antimicrobial coating formulation of claim 6 .
16. A catheter, comprising a surface including the antimicrobial coating formulation of claim 7 .
17. A catheter, comprising a surface including the antimicrobial coating formulation of claim 8 .
18. A catheter, comprising a surface including the antimicrobial coating formulation of claim 9 .