IP Library › Granted Patent US 12,558,462
Granted Patent B2
US 12,558,462 · App. 18/234,308 · Granted Feb 24, 2026

Coatings

Inventors: Gregory M. Cruise (Rancho Santa Margarita, CA); Steve Plotkin (Beaumont, CA); Emily Hsu (Irvine, CA)
Assignee: MicroVention, Inc.
A61L29/085A61L29/041B05D3/067B05D7/546C09D133/14C09D135/02A61L2300/452A61L2400/10A61L2420/02A61L2420/08
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,558,462
App. No.
18/234,308
Granted
Feb 24, 2026
Kind
B2
Abstract

Lubricious coatings for medical devices and their uses are described.

Claims (24)

1 . A coating comprising:

a base coat including a copolymer of a first tetrahydrofurfuryl monomer and a second monomer, and

a top coat including an 8 arm polyethylene glycol macromer;

wherein the coating is lubricious.

2 . The coating of claim 1 , wherein the copolymer has a molecular weight between about 15,000 g/mole and about 150,000 g/mole.

3 . The coating of claim 1 , wherein the top coat is atop the base coat.

4 . The coating of claim 1 , wherein the polyethylene glycol macromer has a molecular weight of 20,000 g/mole.

5 . A catheter or microcatheter coated with the coating of claim 1 .

6 . The coating of claim 1 , wherein the 8 arm polyethylene glycol macromer is derivatized with acryloyl chloride.

7 . The coating of claim 6 , wherein the first copolymer has a molecular weight between about 15,000 g/mole and about 150,000 g/mole.

8 . The coating of claim 6 , wherein the top coat is atop the base coat.

9 . A catheter or microcatheter coated with the coating of claim 6 .

10 . A method of coating a thermoplastic surface, the method comprising:

applying a base coat including a copolymer of a first tetrahydrofurfuryl acrylate monomer and a second monomer to the thermoplastic surface, and

applying a top coat to the base coat, wherein the top coat includes an 8 arm polyethylene glycol macromer derivatized with acryloyl chloride,

wherein the coating is lubricious.

11 . The method of claim 10 , wherein the thermoplastic surface is plasma treated before applying the base coat.

12 . The method of claim 10 , wherein the base coat, the top coat, or both is applied by dipping.

13 . The method of claim 10 , wherein the base coat is exposed to ultraviolet radiation.

14 . The method of claim 13 , wherein the ultraviolet radiation is at a wavelength ranging from about 10 nm to about 400 nm.

15 . The method of claim 14 , wherein the base coat cures for about 0.5 to about 10 minutes.

16 . The method of claim 10 , wherein the top coat is exposed to ultraviolet radiation.

17 . The method of claim 13 , wherein the ultraviolet radiation is at a wavelength ranging from about 10 nm to about 400 nm.

18 . The method of claim 14 , wherein the top coat cures for about 0.5 to about 10 minutes.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 15, 2023
From: PLOTKIN, STEVE; CRUISE, GREGORY M.; HSU, EMILY
To: MICROVENTION, INC.
Reel/Frame 064598/0409 →
Continuity (3)
Continuation 16773685 · Jan 27, 2020
Provisional Application 62797853 · Jan 28, 2019
Related Publication 20230381380A1 · Nov 30, 2023
References Cited (113)
US 4378430A · Modrovich · 1983 [cited by applicant]
US 4459317A · Lambert · 1984 [cited by applicant]
US 4465770A · Modrovich · 1984 [cited by applicant]
US 4487808A · Lambert · 1984 [cited by applicant]
US 4842597A · Brook · 1989 [cited by applicant]
US 5077352A · Elton · 1991 [cited by applicant]
US 5114783A · Hodnett, III · 1992 [cited by applicant]
US 5164321A · Zdunek et al. · 1992 [cited by applicant]
US 5225267A · Ochi et al. · 1993 [cited by applicant]
US 5254395A · Hodnett et al. · 1993 [cited by applicant]
US 5281468A · Klier et al. · 1994 [cited by applicant]
US 5509899A · Fan · 1996 [cited by examiner]
US 5545208A · Wolff et al. · 1996 [cited by applicant]
US 5662960A · Hostettler et al. · 1997 [cited by applicant]
US 5736251A · Pinchuk · 1998 [cited by applicant]
US 5753453A · Kwan · 1998 [cited by applicant]
US 5776661A · Casaletto et al. · 1998 [cited by applicant]
US 5804299A · Nakata et al. · 1998 [cited by applicant]
US 5888656A · Suzuki et al. · 1999 [cited by applicant]
US 6030656A · Hostettler et al. · 2000 [cited by applicant]
US 6083257A · Taylor et al. · 2000 [cited by applicant]
US 6099562A · Ding et al. · 2000 [cited by applicant]
US 6458867B1 · Wang et al. · 2002 [cited by applicant]
US 6673453B2 · Beavers et al. · 2004 [cited by applicant]
US 6706408B2 · Jelle · 2004 [cited by applicant]
US 6803069B2 · Patnaik et al. · 2004 [cited by applicant]
US 7008979B2 · Schottman et al. · 2006 [cited by applicant]
US 7264859B2 · Rouns et al. · 2007 [cited by applicant]
US 7494687B2 · Cox · 2009 [cited by applicant]
US 7544381B2 · Kangas · 2009 [cited by applicant]
US 7544673B2 · DeWitt et al. · 2009 [cited by applicant]
US 7553546B1 · Tan · 2009 [cited by applicant]
US 7770828B2 · Matsumoto et al. · 2010 [cited by applicant]
US 8263720B1 · Salamone et al. · 2012 [cited by applicant]
US 10543299B2 · Baldwin et al. · 2020 [cited by applicant]
US 11188869B2 · Subramaniam et al. · 2021 [cited by applicant]
US 11278649B2 · Baldwin et al. · 2022 [cited by applicant]
US 11744925B2 · Cruise et al. · 2023 [cited by applicant]
US 11827862B2 · Rangwala et al. · 2023 [cited by applicant]
US 11883564B2 · Cruise et al. · 2024 [cited by applicant]
US 12257370B2 · Cruise et al. · 2025 [cited by applicant]
US 20010021745A1 · Laginess et al. · 2001 [cited by applicant]
US 20020082679A1 · Sirhan et al. · 2002 [cited by applicant]
US 20020094322A1 · Lawson et al. · 2002 [cited by applicant]
US 20020120033A1 · Jia et al. · 2002 [cited by applicant]
US 20030069647A1 · Desmond et al. · 2003 [cited by applicant]
US 20030187493A1 · Campbell et al. · 2003 [cited by applicant]
US 20050055044A1 · Kangas · 2005 [cited by applicant]
US 20060052757A1 · Fischer et al. · 2006 [cited by applicant]
US 20060121217A1 · Childs · 2006 [cited by examiner]
US 20060251795A1 · Kobrin et al. · 2006 [cited by applicant]
US 20070154703A1 · Waller et al. · 2007 [cited by applicant]
US 20090047272A1 · Appelbaum · 2009 [cited by examiner]
US 20090076596A1 · Adden et al. · 2009 [cited by applicant]
US 20090112239A1 · To · 2009 [cited by applicant]
US 20090297607A1 · Wang et al. · 2009 [cited by applicant]
US 20090324666A1 · Krongauz · 2009 [cited by examiner]
US 20100105799A1 · Rudd et al. · 2010 [cited by applicant]
US 20100113871A1 · Dias et al. · 2010 [cited by applicant]
US 20100198168A1 · Rooijmans · 2010 [cited by examiner]
US 20100236684A1 · Garlough · 2010 [cited by applicant]
US 20110000788A1 · Deschamps et al. · 2011 [cited by applicant]
US 20110117282A1 · Bernard et al. · 2011 [cited by applicant]
US 20110151000A1 · Schultz · 2011 [cited by examiner]
US 20110160382A1 · Pacetti · 2011 [cited by applicant]
US 20110183867A1 · Davies · 2011 [cited by examiner]
US 20120013043A1 · Weber et al. · 2012 [cited by applicant]
US 20130090291A1 · Gulle · 2013 [cited by examiner]
US 20130243936A1 · Garretson et al. · 2013 [cited by applicant]
US 20130261566A1 · Lockwood et al. · 2013 [cited by applicant]
US 20140011928A1 · Iwasawa et al. · 2014 [cited by applicant]
US 20160024240A1 · Ochiai et al. · 2016 [cited by applicant]
US 20160310633A1 · Vernlund · 2016 [cited by examiner]
US 20180093019A1 · Baldwin et al. · 2018 [cited by applicant]
US 20180325649A1 · Wu · 2018 [cited by examiner]
US 20190201589A1 · Farrell et al. · 2019 [cited by applicant]
US 20200101204A1 · Baldwin et al. · 2020 [cited by applicant]
US 20200157374A1 · Nakabayashi · 2020 [cited by applicant]
US 20210363452A1 · Moran et al. · 2021 [cited by applicant]
US 20220162470A1 · Wu et al. · 2022 [cited by applicant]
US 20230303743A1 · Cruise et al. · 2023 [cited by applicant]
US 20240115772A1 · Cruise et al. · 2024 [cited by applicant]
JP H11315157A · 1999 [cited by applicant]
WO 2003074107 · 2003 [cited by applicant]
WO 2008104573A2 · 2008 [cited by applicant]
WO 2010113632 · 2010 [cited by applicant]
WO 2013130850A1 · 2013 [cited by applicant]
WO 2017158148A1 · 2017 [cited by applicant]
WO 2018209306A1 · 2018 [cited by applicant]
WO 2019116760A1 · 2019 [cited by applicant]
WO 2020036206 · 2020 [cited by applicant]
WO 2020159881A1 · 2020 [cited by applicant]
WO 2020212978A1 · 2020 [cited by applicant]
WO 2021021642A1 · 2021 [cited by applicant]
WO 2022026689A1 · 2022 [cited by applicant]
WO 2023225500A2 · 2023 [cited by applicant]
Bruice, Acid-Base Properties of Amino Acids. Organic Chemistry, Fifth Edition (textbook), Pearson Education Inc., p. 1025 (2007). [cited by applicant]
Weber, Use of ionic and zwitterionic (Tris/BisTris and HEPES) buffers in studies on hemoglobin function. J. Appl. Physiol., 72(4):1611-1615 (1992). [cited by applicant]
Tsai et al., Dopamine-assisted immobilzation of poly(ethylene imine) based polymers for control of cell-surface interactions. Acta Biomaterialia 7, pp. 2518-2525 (2011). [cited by applicant]
Nagaoka et al., “Low friction hydrophilic surface for medical devices,” Journal of Bioactive and Compatible Polymers, 5:212-226 (1990). [cited by applicant]
Vijay et al., “Acrylic acid-methyl methacrylate copolymer for oral prolonged drug release,” J Mater Sci: Mater Med, 2010, 21, 2583-2592. (Year: 2010). [cited by applicant]
Zhu et al., “Polysulfone hemadiafiltration membranes with enhanced anti-fouling and hemocompatibility modified by poly(vinyl pyrrolidone) via in situ cross-linked polymerization,” Material Science and Engineering C 74, … [cited by applicant]
International Search Report and Written Opinion, dated May 30, 2013, for International Application No. PCT/US2013/028380 filed on Feb. 28, 2013. [cited by applicant]
International Search Report and Written Opinion, dated Apr. 14, 2020, for International Application No. PCT/US2020/015240 filed on Jan. 27, 2020. [cited by applicant]
International Search Report and Written Opinion, mailed Oct. 26, 2020, for International Application No. PCT/US2020/043528 filed on Jul. 24, 2020. [cited by applicant]
International Search Report and Written Opinion, dated Nov. 2, 2021, for International Application No. PCT/US2021/043677 filed on Jul. 29, 2021. [cited by applicant]
Extended European Search Report dated Sep. 9, 2024 for related European Patent Application No. 21862969.9. [cited by applicant]
U.S. Appl. No. 18/866,363, filed Nov. 15, 2024. [cited by applicant]
U.S. Appl. No. 19/087,251, filed Mar. 21, 2025. [cited by applicant]
U.S. Appl. No. 19/080,126, filed Mar. 14, 2025. [cited by applicant]
International Search Report and Written Opinion, dated Nov. 14, 2023, for International Application Serial No. PCT/US2023/067044 filed May 16, 2023. [cited by applicant]
Gao et al., “Constructing a biomimetic robust bi-layered hydrophilic lubrication coating on surface of silicone elastomer,” Friction, vol. 10 (Jun. 28, 2021): pp. 1046-1060. [cited by applicant]
Extended European Search Report dated Apr. 20, 2023 for related European Patent Application No. 20848592.0. [cited by applicant]