IP Library › Granted Patent US 12,257,370
Granted Patent B2
US 12,257,370 · App. 16/938,571 · Granted Mar 25, 2025

Coatings for medical devices

Inventors: Gregory M. Cruise (Rancho Santa Margarita, CA); Steve Plotkin (Beaumont, CA); Petr Vasek (Costa Mesa, CA)
Assignee: MicroVention, Inc.
A61L29/085A61L29/049A61B5/150992A61L2400/10A61M25/0045
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Quick Facts
Patent No.
US 12,257,370
App. No.
16/938,571
Granted
Mar 25, 2025
Kind
B2
Abstract

Lubricious or hemocompatible coatings for medical devices are described.

Claims (15)

1. A coated medical device comprising:

a base coat including a copolymer of tetrahydrofurfuryl acrylate and 4-hydroxybutyl acrylate; and

a top coat polymer containing more than two reactive moieties per molecule, wherein the top coat includes a hemocompatible copolymer of a first component and a second component,

wherein the first component is selected from

a (meth)acrylate monomer comprising a diazeniumdiolate or S-nitrosothiol moiety, a hydrophilic monomer, or methoxyethyl acrylate,

wherein the hydrophilic monomer includes an acrylamide, vinyl alcohol, n-vinyl pyrrolidone, hydroxyethyl methacrylate, or poly(ethylene glycol) moiety.

2. The coated medical device of claim 1 , wherein the copolymer has a molecular weight between about 15,000 g/mole and about 150,000 g/mole.

3. The coated medical device of claim 1 , wherein the top coat is atop the base coat, or wherein the top coat is a hemocompatible top coat.

4. The coated medical device of claim 1 , wherein the top coat polymer has a molecular weight between about 500 g/mole to about 100,000 g/mole.

5. The coated medical device of claim 1 , wherein the top coat includes a copolymer of methoxyethyl acrylate and 4-hydroxybutyl acrylate.

6. The coated medical device of claim 1 , wherein the second component is a monomer including an amine, carboxylic acid, or hydroxyl group.

7. The coated medical device of claim 6 , wherein the second component is a monomer selected from:

hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, hydroxybutyl acrylate, hydroxybutyl methacrylate, or a combination thereof;

N-(3-aminopropyl) methacrylamide, 2-aminoethyl methacrylate, 2-aminoethyl methacrylamide, or a combination thereof; or

acrylic acid, methacrylic acid, beta-carboxyethyl acrylate, or a combination thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2020
From: CRUISE, GREGORY M.; PLOTKIN, STEVE; VASEK, PETR
To: MICROVENTION, INC.
Reel/Frame 053308/0896 →
Continuity (2)
Provisional Application 62879287 · Jul 26, 2019
Related Publication 20210023276A1 · Jan 28, 2021
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