Immediate release formulations of cannabinoids
Compositions for the immediate release of one or more cannabinoids, in which the compositions comprise a population of particles. Each particle may comprise the one or more cannabinoids and one or more intra-granule excipients. Alternatively, each particle may comprise the one or more cannabinoids and a porous bead core. The composition may be prepared by a method that involves combining the one or more cannabinoids with the one or more intra-granule excipients, and then granulating the combination, such as through fluid bed granulation, shear-induced wet granulation, or spray granulation. The composition may also be prepared by a method that involves mixing the one or more cannabinoids with a population of porous bead cores.
1. A composition for immediate release of one or more cannabinoids, the composition comprising a population of particles, wherein each particle comprises:
(a) the one or more cannabinoids;
(b) a porous bead core;
wherein the composition releases at least about 30% of the one or more cannabinoids over a period of about 30 minutes or less; and
wherein the porous bead core comprises a silica bead or biodegradable bead.
2. The composition of claim 1 , wherein the one or more cannabinoids comprises Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), or a combination thereof.
3. The composition of claim 1 , wherein the one or more cannabinoids comprises a combination of THC and CBD.
4. The composition of claim 1 , wherein the porous bead core comprises a silica bead or porous biodegradable glass bead.
5. The composition of claim 1 , wherein the composition releases about 30% of the one or more cannabinoids over a period of about 15 minutes or less.
6. The composition of claim 1 , wherein about 80% of the particles in the composition comprise a diameter of between about 2 μm and about 500 μm.
7. A composition for immediate release of one or more cannabinoids, the composition comprising a population of particles, wherein each particle comprises:
(a) the one or more cannabinoids;
(b) a porous bead core;
wherein the composition releases at least about 30% of the one or more cannabinoids over a period of about 30 minutes or less; and
wherein the porous bead core comprises a calcium carbonate or calcium phosphate bead.
8. The composition of claim 7 , wherein the porous bead core comprises a calcium carbonate bead.
9. The composition of claim 8 , wherein the porous bead core comprises a calcium phosphate bead.