Methods and systems for high-throughput blood component collection
Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.
1. A method for collecting a blood component through apheresis, the method comprising:
drawing whole blood into a first port of a separation bladder through a first line;
adding anticoagulant to the whole blood from an anticoagulant source;
spinning the separation bladder to separate the whole blood into a first blood component predominantly including plasma and a second blood component including red blood cells;
directing the first blood component from the separation bladder into a container; and
returning the second blood component from the separation bladder through the first port in the separation bladder and back to the first line.
2. The method of claim 1 , wherein the separation bladder further comprises a second port and the directing the first blood component occurs in a first direction through the second port of the separation bladder into the container, wherein a portion of the first blood component is returned through the second port and into the separation bladder in a second direction opposite to the first direction to facilitate the returning of the second blood component through the first port back to the first line.
3. The method of claim 2 , wherein the directing the first blood component occurs through the second port of the separation bladder, and the method further comprises:
initiating the returning of the second blood component from the separation bladder through the first port in the separation bladder and back to the first line by returning the portion of the first blood component through the second port when a presence of at least one of red blood cells, high hematocrit blood, and/or platelets is detected in a stream exiting the second port of the separation bladder in the first direction.
4. The method of claim 2 , further comprising repeating the directing the first blood component and returning the portion of the first blood component, so that a sequence occurs that includes at least directing the first blood component, returning a first portion of the first blood component, followed by directing the first blood component, and returning a second portion of the first blood component.
5. The method of claim 1 , wherein the separation bladder further comprises a second port, the directing the first blood component occurs in a first direction through the second port of the separation bladder into the container, wherein the method further comprises directing a portion of the first blood component from the container into the separation bladder through the second port in a second direction opposite to the first direction that occurs concurrently with the spinning of the separation bladder.
6. The method of claim 4 , wherein the spinning occurs concurrently with at least one of the directing and the returning.
7. The method of claim 1 , wherein the directing and the returning occur as a continuous process without stopping the spinning.
8. The method of claim 1 , wherein the whole blood is drawn from a donor and the first line is in fluid communication with the donor so that the returning further includes directing the second blood component through the first line and back into the donor.
9. The method of claim 1 , wherein the first line is in fluid communication with a chamber and after the returning, collecting, at least temporarily, at least a portion of the second blood component in the chamber.
10. The method of claim 9 , wherein the drawing the whole blood through the first line further comprises directing the whole blood into a bypass around the chamber.
11. The method of claim 1 , further comprising repeating the directing of the first blood component and the returning of the second blood component in an alternating sequence.
12. A method for collecting a blood component through apheresis, the method comprising:
introducing whole blood into a separation bladder from a first line;
spinning the separation bladder to separate the whole blood into at least a plasma product and a blood component including red blood cells;
directing the plasma product from the separation bladder into a container;
monitoring an output stream from the separation bladder to detect a presence of at least one of red blood cells, high hematocrit blood product, and/or platelets indicating removal from the separation bladder; and
after detecting the presence of at least one of red blood cells, high hematocrit blood product, and/or platelets, returning a portion of the plasma product back into the separation bladder to move the blood component including red blood cells out of the separation bladder to the first line.
13. The method of claim 12 , wherein the separation bladder has a first port and a second port and the directing the plasma product occurs through the second port of the separation bladder, wherein the returning the portion of the plasma product back into the separation bladder is through the second port to facilitate movement of blood component including the red blood cells through the first port and out of the separation bladder.
14. The method of claim 12 , wherein the separation bladder has a first port and a second port and the directing the plasma product occurs through the second port of the separation bladder, wherein the returning the portion of the plasma product back into the separation bladder is through the second port occurs concurrently with the spinning the separation bladder.
15. The method of claim 12 , wherein the spinning occurs concurrently with at least one of the directing the plasma product and the returning the portion of the plasma product.
16. The method of claim 12 , wherein the directing the plasma product and the returning the portion of the plasma product occur as a continuous process without stopping the spinning.
17. The method of claim 12 , wherein the whole blood is drawn from a donor and the first line is in fluid communication with the donor so that the blood component including red blood cells move through the first line and back to the donor.
18. The method of claim 12 , wherein the first line is in fluid communication with a chamber and after the returning, collecting, at least temporarily, at least a portion of the blood component including red blood cells in the chamber.
19. The method of claim 18 , further comprising:
passing the blood component including red blood cells through the chamber and collecting, at least temporarily, at least a portion of the blood component in the chamber; and
directing whole blood into a bypass around the chamber when the introducing the whole blood into the separation bladder from the first line occurs.
20. The method of claim 12 , further comprising repeating the directing the plasma product and the returning the portion of the plasma product, so that a sequence occurs that includes at least directing plasma product, returning a first portion of the plasma product, followed by directing the plasma product, and returning a second portion of the plasma product.