Carotid sinus nerve stimulation

1. A method for stimulating nerve fibers to treat a condition in a patient, the method comprising:

identifying carotid sinus nerve afferent fibers in a first side of a patient's neck;

identifying cardiac-specific vagal nerve afferent fibers in the first side of the patient's neck;

placing a first multipolar electrode device around the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers;

stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers, using the first multipolar electrode device;

sensing a heart rate indicative of an activity level of the patient; and

adjusting stimulation frequency of the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers based on the sensed heart rate, wherein an increase in the sensed heart rate causes an increase in the stimulation frequency.

2. The method of claim 1 , wherein stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers comprises sending a stimulation signal from a pulse generator implanted in the patient through a first lead to the first multipolar electrode device.

3. The method of claim 1 , wherein identifying the carotid sinus nerve afferent fibers comprises identifying a nerve plexus near the carotid sinus.

4. The method of claim 1 , further comprising:

identifying carotid sinus nerve afferent fibers in a second side of the patient's neck;

identifying cardiac-specific vagal nerve afferent fibers in the second side of the patient's neck;

placing a second multipolar electrode device around the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers in the second side; and

stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers in the second side, using the second multipolar electrode device.

5. The method of claim 4 , wherein stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers comprises:

sending a first stimulation signal from a pulse generator implanted in the patient through a first lead to the first multipolar electrode device; and

sending a second stimulation signal from a pulse generator implanted in the patient through a second lead to the second multipolar electrode device.

6. The method of claim 1 , wherein the multipolar electrode device is a hexapolar electrode.

7. The method of claim 1 , wherein stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers comprises providing a stimulation signal with parameters in the ranges of 1-25 mA amplitude, 0.06-5 ms pulse widths and 1-5000 Hz frequency.

8. The method of claim 7 , wherein stimulation is at a frequency of between 80 Hz and 120 Hz.

9. The method of claim 1 , wherein adjusting the one or more parameters of stimulation comprises increasing a frequency of the stimulation if the sensed heart rate is above a first predefined threshold and/or decreasing the frequency of the stimulation if the sensed heart rate is below a second predefined threshold.

10. The method of claim 1 , wherein sensing the heart rate comprises using data selected from the group consisting of an electrocardiogram, a blood pressure waveform, a phonocardiograph and an arterial distension waveform.

11. The method of claim 1 , further comprising timing the stimulating by delivering all of a pulse train of the stimulation during a diastolic phase of the patient's heartbeat.

12. The method of claim 1 , wherein stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers comprises selectively stimulating only afferent nerve fibers and not stimulating efferent nerve fibers.

13. The method of claim 1 , wherein the sensed heart rate is a first sensed heart rate, the method further comprising:

sensing a second heart rate of the patient; and

adjusting the stimulation frequency based on the second sensed heart rate.

14. The method of claim 1 , wherein the activity level comprises sitting, standing, or walking.

15. The method of claim 1 , wherein the stimulation frequency corresponds to a number of electrical impulses.

16. The method of claim 1 , wherein adjusting the stimulation frequency comprises adjusting the stimulation frequency such that the number of electrical impulses is constant per cardiac cycle.

17. An implantable system for stimulating nerve fibers to treat a condition in a patient, the system comprising:

a pulse generator;

a first multipolar electrode device configured to wrap around carotid sinus nerve afferent fibers and cardiac-specific vagal nerve afferent fibers in a first side of a patient's neck;

a first lead attached at one end to the pulse generator and at an opposite end to the first multipolar electrode device; and

a computing device wirelessly connected to the pulse generator and configured to:

receive a sensed heart rate from an electrocardiogram sensor, wherein the sensed heart rate is indicative of an activity level of the patient;

transmit stimulation frequency to the pulse generator, wherein an increase in the sensed heart rate causes an increase in the stimulation frequency;

time a stimulation of the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers to the sensed heart rate; and

adjust stimulation of the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers based on the stimulation frequency.

18. The system of claim 17 , wherein the first multipolar electrode device is a hexapolar electrode.

19. The system of claim 17 , wherein the first multipolar electrode device is flexible and has two flaps connected along one edge and open along an opposite edge, wherein the open opposite edge is configured to admit the carotid sinus nerve afferent fibers and cardiac-specific vagal nerve afferent fibers.

20. The system of claim 17 , further comprising:

a second multipolar electrode device configured to wrap around carotid sinus nerve afferent fibers and cardiac-specific vagal nerve afferent fibers in a second side of the patient's neck; and

a second lead attached at one end to the pulse generator and at an opposite end to the second multipolar electrode device.

21. The system of claim 20 , wherein the system comprises the electrocardiogram sensor, the system further comprising:

a third lead attached at one end to the pulse generator and at an opposite end to the electrocardiogram sensor.

22. The system of claim 21 , wherein the electrocardiogram sensor comprises:

a paddle-shaped substrate; and

multiple electrodes positioned along the paddle-shaped substrate.

23. The system of claim 17 , wherein the first multipolar electrode device is configured to selectively stimulate the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers and to not stimulate efferent nerve fibers.

24. The system of claim 17 , wherein timing the stimulation comprises:

delivering 25 percent of a pulse train of the stimulation at the onset of a sensed signal corresponding to a systolic phase of the patient's heartbeat; and

delivering a remaining 75 percent of the pulse train during a diastolic phase of the patient's heartbeat.

25. The system of claim 17 , wherein the stimulation frequency corresponds to a number of electrical impulses.

26. The system of claim 17 , wherein adjusting stimulation comprises maintaining a number of electrical impulses per cardiac cycle.

27. An implantable system for stimulating nerve fibers to treat a condition in a patient, the system comprising:

a pulse generator;

a multipolar electrode device configured to stimulate afferent fibers associated with baroreceptors and/or a carotid sinus nerve of a patient;

a lead attached and operably coupled to the pulse generator and first multipolar electrode device; and

a computing device connected to the pulse generator and configured to:

provide a first stimulation via the multipolar electrode device;

after providing the stimulation, receive a sensed heart rate from the patient, wherein the sensed heart rate is indicative of an activity level of the patient;

transmit, to the pulse generator, a stimulation frequency correlated to the sensed heart rate, such that an increase in the sensed heart rate causes an increase in the stimulation frequency; and

provide a second stimulation based on the stimulation parameter.

28. The system of claim 27 , wherein the stimulation frequency corresponds to a number of electrical impulses.

29. The system of claim 27 , wherein providing the second stimulation comprises maintaining a number of electrical impulses per cardiac cycle.