Apparatus and method for treating a patient using vibration stimuli, tactile stimuli and/or thermal stimuli
A device and method are provided for treating a patient with vibration and/or tactile and/or thermal stimuli. The device includes first and second stimulating units for generating first and second stimuli respectively. The stimuli are vibration and/or tactile and/or thermal stimuli, and each of the stimuli is repeated on average at a frequency of 1 to 60 Hz. The stimuli are generated partly at different times.
1. A method for treating a patient with a disease in which there is an increased neuronal synchronization of neuronal activity of a population of neurons of the patient, the method comprising:
generating, by a first stimulation unit, first stimuli to skin of the patient that, upon being received by receptors disposed in or beneath the skin of the patient and transmitted to a first sub-population of the population of neurons, effect a reset of a phase of neuronal activity of the first sub-population;
generating, by a second stimulation unit, second stimuli to the skin of the patient that, upon being received by receptors disposed in or beneath the skin of the patient and transmitted to a second sub-population of the population of neurons, effect a reset of a phase of neuronal activity of the second sub-population,
wherein the first and second stimuli are at least one of vibratory stimuli, tactile stimuli and thermal stimuli,
wherein the generating of the first and second stimuli are performed to apply the first and second stimuli to the skin of the patient at different target regions and least partially different times such that the phase of the neuronal activity of the first and the second sub-population are reset at different times and such that the first and the second sub-population have different phases of neuronal activity by controlling each of the first stimulation unit and the second stimulation unit to generate the stimuli during periodic stimulation time periods, and
wherein the generating, by the first stimulation unit and the second stimulation unit, generates at most one of the stimuli during each stimulation time period of the stimulation time periods and, among the periodic stimulation time periods, an order in which the first stimulation unit and the second stimulation unit generate the respective stimuli per stimulation period is varied.
2. The method according to claim 1 , wherein the first and second stimuli are respectively repeated on average at a frequency of 1 to 60 Hz during a stimulation period.
3. The method in accordance with claim 1 , wherein the varying of the order in which the first and second stimulation units generate the respective stimuli per stimulation period is according to a stochastic manner, a deterministic manner or a mixed stochastic and deterministic manner.
4. The method in accordance with claim 1 , wherein the first and second stimulation units are part of a plurality of stimulation units and comprises between two and twelve stimulation units.
5. The method in accordance with claim 1 , further comprising generating a pause between two subsequent stimulation time periods during which no stimulation by the first and second stimulation units occurs.
6. The method in accordance with claim 1 , further comprising performing a stimulation according to a scheme comprising a number of n mutually following stimulation time periods and subsequently a pause period during which no stimulation by the first and second stimulation units occurs, wherein n is a whole number in a range from 1 to 10.
7. The method in accordance with claim 6 , further comprising continuing or modifying the scheme periodically or stochastically or deterministically or in mixed stochastic and deterministic manner.
8. The method in accordance with claim 6 , further comprising modifying the scheme periodically by adapting at least one of the number n of mutually following stimulation time periods and a length of the pause period.
9. The method in accordance with claim 6 , further comprising varying the order in which the first and second stimulation units generates the respective stimuli per stimulation period among at least one of the n mutually following stimulation time periods or among mutually following schemes.
10. The method in accordance with claim 1 , wherein the first and second stimulation units are part of a plurality of stimulation units, and wherein the method further comprises selecting per stimulation time period a number and selection of stimulation units of the plurality of stimulation units participating in the stimulation, wherein at least one of the number and selection of the stimulation units participating in the stimulation varies among the stimulation time periods.
11. The method in accordance with claim 1 , further comprising measuring pathological features experienced by the patient with the disease in response to the generated stimuli and adjusting the stimuli based on the measured pathological features.