IP Library › Granted Patent US 12,243,637
Granted Patent B2
US 12,243,637 · App. 18/209,676 · Granted Mar 4, 2025

Systems and methods for artificial intelligence-based image analysis for detection and characterization of lesions

Inventors: Johan Martin Brynolfsson (Helsingborg, SE); Kerstin Elsa Maria Johnsson (Lund, SE); Hannicka Maria Eleonora Sahlstedt (Malmö, SE)
Assignee: EXINI Diagnostics AB
G16H30/40G06T7/0012G06T7/11G16H50/20G16H50/30G06T2207/10072G06T2207/30056G06T2207/30096
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Quick Facts
Patent No.
US 12,243,637
App. No.
18/209,676
Granted
Mar 4, 2025
Kind
B2
Abstract

Presented herein are systems and methods that provide for improved detection and characterization of lesions within a subject via automated analysis of nuclear medicine images, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) images. In particular, in certain embodiments, the approaches described herein leverage artificial intelligence (AI) to detect regions of 3D nuclear medicine images corresponding to hotspots that represent potential cancerous lesions in the subject. The machine learning modules may be used not only to detect presence and locations of such regions within an image, but also to segment the region corresponding to the lesion and/or classify such hotspots based on the likelihood that they are indicative of a true, underlying cancerous lesion. This AI-based lesion detection, segmentation, and classification can provide a basis for further characterization of lesions, overall tumor burden, and estimation of disease severity and risk.

Claims (64)

1. A method for automatically processing 3D images of a subject to identify and/or characterize cancerous lesions within the subject, the method comprising:

(a) receiving, by a processor of a computing device, a 3D functional image of the subject obtained using a functional imaging modality;

(b) automatically detecting, by the processor, using a machine learning module, one or more hotspots within the 3D functional image, each hotspot corresponding to a local region of elevated intensity with respect to its surrounding and representing a potential cancerous lesion within the subject, thereby creating a 3D hotspot map, identifying, for each hotspot, a corresponding 3D hotspot volume within the 3D functional image, wherein the machine learning module receives, as input, at least a portion of the 3D functional image and generates the 3D hotspot map as output; and

(c) storing and/or providing, for display and/or further processing, the 3D hotspot map,

wherein the 3D functional image comprises a positron emission tomography (PET) or a single-photon emission computed tomography (SPECT) image obtained following administration of an agent to the subject.

2. The method of claim 1 , wherein the machine learning module receives, as input, a 3D segmentation map that identifies one or more volumes of interest (VOIs) within the 3D functional image, each VOI corresponding to a particular target tissue region and/or a particular anatomical region within the subject.

3. The method of claim 1 ,

comprising receiving, by the processor, a 3D anatomical image of the subject obtained using an anatomical imaging modality, wherein the 3D anatomical image comprises a graphical representation of tissue within the subject,

and wherein the machine learning module receives at least two channels of input, said input channels comprising a first input channel corresponding to at least a portion of the 3D anatomical image and a second input channel corresponding to the portion of the 3D functional image.

4. The method of claim 3 , wherein the machine learning module receives, as input, a 3D segmentation map that identifies, within the 3D functional image and/or the 3D anatomical image, one or more volumes of interest (VOIs), each VOI corresponding to a particular target tissue region and/or a particular anatomical region.

5. The method of claim 4 , comprising automatically segmenting, by the processor, the 3D anatomical image, thereby creating the 3D segmentation map.

6. The method of claim 1 , wherein the machine learning module is a region-specific machine learning module that receives, as input, a specific portion of the 3D functional image corresponding to one or more specific tissue regions and/or anatomical regions of the subject.

7. The method of claim 1 , comprising:

(d) determining, by the processor, for each hotspot of at least a portion of the hotspots, a lesion likelihood classification corresponding to a likelihood of the hotspot representing a lesion within the subject.

8. The method of claim 7 , wherein step (d) comprises using the machine learning module to determine, for each hotspot of the portion, the lesion likelihood classification.

9. The method of claim 7 , wherein step (d) comprises using a second machine learning module to determine the lesion likelihood classification for each hotspot.

10. The method of claim 9 , comprising determining, by the processor, for each hotspot, a set of one or more hotspot features and using the set of the one or more hotspot features as input to the second machine learning module.

11. The method of claim 7 , comprising:

(e) selecting, by the processor, based at least in part on the lesion likelihood classifications for the hotspots, a subset of the one or more hotspots corresponding to hotspots having a high likelihood of corresponding to cancerous lesions.

12. The method of claim 1 , comprising:

(f) adjusting intensities of voxels of the 3D functional image, by the processor, to correct for intensity bleed from one or more high-intensity volumes of the 3D functional image, each of the one or more high-intensity volumes corresponding to a high-uptake tissue region within the subject associated with high radiopharmaceutical uptake under normal circumstances.

13. The method of claim 12 , wherein step (f) comprises correcting for intensity bleed from a plurality of high-intensity volumes one at a time, in a sequential fashion.

14. The method of claim 12 , wherein the one or more high-intensity volumes correspond to one or more high-uptake tissue regions selected from the group consisting of a kidney, a liver, and a bladder.

15. The method of claim 1 , comprising:

(g) determining, by the processor, for each of at least a portion of the one or more hotspots, a corresponding lesion index indicative of a level of radiopharmaceutical uptake within and/or size of an underlying lesion to which the hotspot corresponds.

16. The method of claim 15 , wherein step (g) comprises comparing an intensity intensities) of one or more voxels associated with the hotspot with one or more reference values, each reference value associated with a particular reference tissue region of a reference volume corresponding to the reference tissue region.

17. The method of claim 16 , wherein the one or more reference values comprise one or more members selected from the group consisting of an aorta reference value associated with an aorta portion of the subject and a liver reference value associated with a liver of the subject.

18. The method of claim 15 , comprising using the determined lesion index values compute an overall risk index for the subject, indicative of a cancer status and/or risk for the subject.

19. The method of claim 1 , comprising determining, by the processor, for each hotspot, an anatomical classification corresponding to a particular anatomical region and/or group of anatomical regions within the subject in which the potential cancerous lesion that the hotspot represents is determined to be located.

20. The method of claim 1 , comprising:

(h) causing, by the processor, for display within a graphical user interface (GUI), rendering of a graphical representation of at least a portion of the one or more hotspots for review by a user.

21. The method of claim 20 , comprising:

(i) receiving, by the processor, via the GUI, a user selection of a subset of the one or more hotspots confirmed via user review as likely to represent underlying cancerous lesions within the subject.

22. The method of claim 1 , wherein the agent comprises a PSMA binding agent.

23. The method of claim 22 , wherein the agent comprises [18F]DCFPyL.

24. The method of claim 1 , wherein the machine learning module implements a neural network.

25. The method of claim 1 , wherein the processor is a processor of a cloud-based system.

26. The method of claim 1 , wherein the machine learning module comprises a convolutional neural network (CNN).

27. A method for automatically processing 3D images of a subject to identify and/or characterize cancerous lesions within the subject, the method comprising:

(a) receiving, by a processor of a computing device, a 3D functional image of the subject obtained using a functional imaging modality;

(b) receiving, by the processor, a 3D anatomical image of the subject obtained using an anatomical imaging modality, wherein the 3D anatomical image comprises a graphical representation of tissue within the subject;

(c) automatically detecting, by the processor, using a machine learning module, one or more hotspots within the 3D functional image, each hotspot corresponding to a local region of elevated intensity with respect to its surrounding and representing a potential cancerous lesion within the subject, thereby creating a 3D hotspot map, identifying, for each hotspot, a corresponding 3D hotspot volume within the 3D functional image,

wherein the machine learning module receives at least two channels of input, said input channels comprising a first input channel corresponding to at least a portion of the 3D functional image and a second input channel corresponding to at least a portion of the 3D anatomical image and/or anatomical information derived therefrom, and generates the 3D hotspot map as output; and

(d) storing and/or providing, for display and/or further processing, the 3D hotspot map,

wherein the 3D functional image comprises a positron emission tomography (PET) or a single-photon emission computed tomography (SPECT) image obtained following administration of an agent to the subject.

28. The method of claim 27 , wherein the machine learning module comprises a convolutional neural network (CNN).

29. A system for automatically processing 3D images of a subject to identify and/or characterize cancerous lesions within the subject, the system comprising:

a processor of a computing device; and

a memory having instructions stored thereon, wherein the instructions, when executed by the processor, cause the processor to:

(a) receive a 3D functional image of the subject obtained using a functional imaging modality;

(b) automatically detect, using a machine learning module, one or more hotspots within the 3D functional image, each hotspot corresponding to a local region of elevated intensity with respect to its surrounding and representing a potential cancerous lesion within the subject, thereby creating a 3D hotspot map, identifying, for each hotspot, a corresponding 3D hotspot volume within the 3D functional image, wherein the machine learning module receives, as input, at least a portion of the 3D functional image and generates the 3D hotspot map as output; and

(c) store and/or provide, for display and/or further processing, the 3D hotspot map,

wherein the 3D functional image comprises a positron emission tomography (PET) or single-photon emission computed tomography (SPECT) image obtained following administration of an agent to the subject.

30. The system of claim 29 , wherein the machine learning module comprises a convolutional neural network (CNN).

31. A system for automatically processing 3D images of a subject to identify and/or characterize cancerous lesions within the subject, the system comprising:

a processor of a computing device; and

a memory having instructions stored thereon, wherein the instructions, when executed by the processor, cause the processor to:

(a) receive a 3D functional image of the subject obtained using a functional imaging modality;

(b) receive a 3D anatomical image of the subject obtained using an anatomical imaging modality, wherein the 3D anatomical image comprises a graphical representation of tissue within the subject;

(c) automatically detect, using a machine learning module, one or more hotspots within the 3D functional image, each hotspot corresponding to a local region of elevated intensity with respect to its surrounding and representing a potential cancerous lesion within the subject, thereby creating a 3D hotspot map, identifying, for each hotspot, a corresponding 3D hotspot volume within the 3D functional image,

wherein the machine learning module receives at least two channels of input, said input channels comprising a first input channel corresponding to at least a portion of the 3D functional image and a second input channel corresponding to at least a portion of the 3D anatomical image and/or anatomical information derived therefrom, and generates the 3D hotspot map as output; and

(d) store and/or provide, for display and/or further processing, the 3D hotspot map,

wherein the 3D functional image comprises a positron emission tomography (PET) or single-photon emission computed tomography (SPECT) image obtained following administration of an agent to the subject.

32. The system of claim 31 , wherein the machine learning module comprises a convolutional neural network (CNN).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 27, 2023
From: BRYNOLFSSON, JOHAN MARTIN; JOHNSSON, KERSTIN ELSA MARIA; SAHLSTEDT, HANNICKA MARIA ELEONORA
To: EXINI DIAGNOSTICS AB
Reel/Frame 064404/0525 →
Continuity (3)
Continuation 17008411 · Aug 31, 2020
Provisional Application 63048436 · Jul 6, 2020
Related Publication 20230420112A1 · Dec 28, 2023
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