Granted Patent B2

US 12,245,790 · App. 16/984,690 · Granted Mar 11, 2025

Inventors: David R. Fischell (Fair Haven, NJ); Tim A. Fischell (Kalamazoo, MI); Robert Ryan Ragland (Temecula, CA); Darrin James Kent (Murrieta, CA); Andy Edward Denison (Temecula, CA); Eric Thomas Johnson (Temecula, CA); Jeff Alan Burke (Winchester, CA); Christopher Scott Hayden (Winchester, CA); Robert E. Fischell (Dayton, MD)

Assignee: Ablative Solutions, Inc.

A61B17/3403A61B17/3478A61B18/00A61B18/04A61B18/06A61B18/1492A61M25/0084A61B2018/00214A61B2018/00267A61B2018/00279A61B2018/00404A61B2018/00434A61B2018/00511A61B2018/00517A61B2018/00577A61B2018/046A61B2018/143A61B2018/1432A61B2018/1475A61B2090/3966A61B2218/002A61M2025/0087A61M25/10

Abstract

Claims (32)

1. A transvascular method of minimizing pain during the treatment of extravascular tissue, comprising:

providing a catheter having an elongate flexible body, a proximal end, a distal end, and a needle disposed within a lumen of a guide tube;

transvascularly positioning the distal end of the catheter at a treatment site;

deploying the needle into a vessel wall at a depth of more than 0.5 mm from an inside surface of the vessel wall while maintaining the guide tube against the vessel wall, without the guide tube puncturing the vessel wall;

a single injection of an ablative agent with a first flow rate for desensitizing pain nerves by injecting the ablative agent through the needle wherein the ablative fluid spreads out both radially and circumferentially and a second flow rate for ablating sympathetic nerves by injecting the ablative agent through the needle.

2. The transvascular method of claim 1 , further comprising deploying at least three needles into the vessel wall.

3. The transvascular method of claim 2 , wherein the depth is between 0.5 mm and 4 mm.

4. The transvascular method of claim 3 , wherein the depth is preset.

5. The transvascular method of claim 3 , wherein desensitizing pain nerves comprises injecting a first volume of the ablative agent at a site.

6. The transvascular method of claim 5 , wherein ablating sympathetic nerves comprises injecting a second volume of the ablative agent at the site.

7. The transvascular method of claim 6 , wherein the first volume of the ablative agent is injected at the first flow rate, and the second volume of the ablative agent is injected at the second, faster flow rate.

8. The transvascular method of claim 1 , wherein the ablative agent is the same agent which is injected continuously in a single infusion.

9. The transvascular method of claim 1 , wherein the the ablative agent is ethanol.

10. The transvascular method of claim 1 , wherein the first flow rate is injected slower than 4 ml per minute.

11. The transvascular method of claim 1 , wherein the first flow rate is injected over a time period more than 30 seconds.

12. A transvascular method of minimizing pain during the treatment of extravascular tissue, comprising:

providing a catheter having an elongate flexible body, a proximal end, a distal end, and a needle;

transvascularly positioning the distal end at a treatment site;

deploying the needle into a vessel wall at a depth of more than 0.5 mm from an inside surface of the vessel wall;

a single injection of an ablative agent for desensitizing pain nerves by injecting a first volume of the ablative agent through the needle, wherein the first volume is injected in a continuous, slow rate and ablating sympathetic nerves by injecting a second volume of the ablative agent through the needle at a faster rate.

13. The transvascular method of claim 12 , further comprising deploying at least three needles into the vessel wall.

14. The transvascular method of claim 12 , wherein the first volume is injected in the continuous, slow rate between 1 ml/minute and 4 ml/minute.

15. The transvascular method of claim 12 , further comprising a delay between injecting the first volume of the ablative agent and injecting the second volume of the ablative agent is at least 30 seconds.

16. A transvascular method of minimizing pain during the treatment of extravascular tissue, comprising:

providing a catheter having an elongate flexible body, a proximal end, a distal end, and a needle;

transvascularly positioning the distal end of the catheter at a treatment site;

deploying the needle into a vessel wall at a depth of more than 0.5 mm from an inside surface of the vessel wall;

a single injection of an ablative agent for desensitizing pain nerves by injecting a first volume of the ablative agent through the needle and ablating sympathetic nerves by injecting a second volume of the ablative agent through the needle, wherein the first volume of the ablative agent is injected at a first rate, and the second volume of the ablative agent is injected at a second, faster rate, wherein the second volume of the ablative agent produces a multiplicity of ablation zones that intersect to form an ablative ring around the circumference of the vessel wall.

17. The transvascular method of claim 16 , further comprising at least a 5 second delay between injecting the first volume of the ablative agent and injecting the second volume of the ablative agent.

18. The transvascular method of claim 16 , wherein the first volume of the ablative agent is injected in a continuous injection rate.

19. The transvascular method of claim 16 , wherein the first volume of the ablative agent is injected slower than 4 ml per minute.

20. The transvascular method of claim 16 , wherein the ablative agent is ethanol.

Assignments (1)

Continuity (6)

References Cited (400)