IP Library › Granted Patent US 12,251,201
Granted Patent B2
US 12,251,201 · App. 16/995,749 · Granted Mar 18, 2025

Device and method for medical diagnostics

Inventor: Alexander Poltorak (Monsey, NY)
Assignee: Poltorak Technologies LLC
A61B5/02055A61B5/0022A61B5/029A61B5/0533A61B5/369A61B5/389A61B5/6802A61B5/6847A61B5/7264A61B5/7275A61B5/746G16H50/30A61B5/021A61B5/024A61B5/02416A61B5/0816A61B5/091A61B5/7239A61B2503/40A61B2560/0257A61B2562/0247A61B2562/0257A61B2562/0271G16H50/50G16H50/70
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Quick Facts
Patent No.
US 12,251,201
App. No.
16/995,749
Granted
Mar 18, 2025
Kind
B2
Abstract

A method and device for analysis of sampled physiological parameters according to at least a second-order process over time, e.g., second-order differential equation or model, for use in therapeutic, diagnostic, or predictive health applications. The system may generate an alert regarding a present or predicted health abnormality. The biometric device may be implantable, wearable, contact or non-contact, and may communicate through a network, to send an alert. The system may further comprise an actuator or therapeutic device to perform an action based on the at least second-order process.

Claims (36)

1. An apparatus for measuring at least one physiological parameter describing a state of a homeostatically controlled system of a user subject to a process selected from the group consisting of a thermal process, a neurological process, a muscular process, a skeletal process, a digestive process, a cardiac process, a respiratory process, a renal process, a dermal process, a reproductive organ process, a hemodynamic process, an electrochemical process, a blood chemistry process, and a vascular process, comprising:

an input port configured to receive a signal generated by a sensor corresponding to the at least one physiological parameter;

a non-volatile memory configured to store a sequence of values representing the at least one physiological parameter over time;

at least one processor configured to:

store the sequence values in the non-volatile memory;

determine a statistical uncertainty of a prior estimate of the sequence of values;

perform a dynamic analysis of the homeostatically controlled system, based on the stored sequence of values, with a Kalman filter based on an adaptive at least second-order predictive model for said at least one physiological parameter, employing a discrete time change in rate of change of the at least one physiological parameter of the biological system and the determined statistical uncertainty;

predict a future state of the homeostatically controlled system dependent on the dynamic analysis and the signal, with the adaptive at least second order predictive model;

update the adaptive at least second order predictive model dependent on the dynamic analysis; and

determine an inability of the homeostatically controlled system of the user to maintain homeostasis, based on the predicted future state of the homeostatically controlled system and the dynamic analysis;

automatically issuing an alert selectively dependent on the deviation of the homeostatically controlled system of the user from homeostasis; and

at least one actuator responsive to the predicted future state and the determined inability of the homeostatically controlled system of the user to maintain homeostasis, configured to alter the at least one physiological parameter.

2. The apparatus according to claim 1 , wherein the at least one physiological parameter is selected from at least one of a heart rate, a cardiac stroke volume, a blood pressure, a respiratory rate, respiratory volume, and a body temperature.

3. The apparatus according to claim 1 , wherein the apparatus is an implantable device.

4. The apparatus according to claim 1 , wherein the apparatus is wearable.

5. The apparatus according to claim 1 , wherein the physiological parameter is derived from at least one of a motion sensor, a pressure sensor, a thermometer, a galvanic skin sensor, a photoplethysmography sensor, an electroencephalogram sensor, an electromyogram sensor, a blood flow sensor, a bio-impedance sensor, and an optical sensor.

6. The apparatus according to claim 1 , wherein the at least one automated processor is further configured to communicate with an online server.

7. The apparatus according to claim 1 , wherein the adaptive at least second order predictive model comprises a Kalman filter.

8. The apparatus according to claim 1 , wherein the at least one automated processor is further configured to:

sample values of said at least one physiological parameter of the biological system over a period of time;

create a dataset of the sequence of values;

statistically analyze the dataset comprising the determination of the statistical uncertainty of the prior estimate as an error covariance matrix;

determine a discrete time rate of change as an approximation of a first derivative of said at least one physiological parameter from the dataset of values;

determine the discrete time change in rate of change as an approximation of at least one derivative of at least second order of said at least one physiological parameter from the dataset of values; and

use at least the discrete time rate of change, the discrete time change in rate of change and the error covariance matrix to predict the future state of said at least one physiological parameter beyond the time period.

9. The apparatus according to claim 7 , wherein the at least one automated processor is further configured to tune the Kalman filter by adjusting a Kalman gain, encode a time-varying state estimate matrix and a time-varying covariance matrix.

10. The-apparatus according to claim 8 , wherein the dataset of values is organized in a relational database, wherein the table of the values of said at least one physiological parameter is linked with a table of subjective health data representing time points within a time range at which the values of said at least one physiological parameter were sampled.

11. The method of claim 8 , wherein the dataset of values is organized in a relational database, wherein the table of the values of said at least one physiological parameter is linked with a first table of physiological data from other users of the same type as that from which the values of said at least one physiological parameter were sampled and a second table of physiological data acquired over a time range different from that from which the values of said at least one physiological parameter were sampled.

12. The method of claim 1 , wherein the adaptive at least second order predictive model comprises a recursive discrete data linear filter which is configured to determine a minimum variance of a state of the at least one physiological parameter based on a state equation and a measurement equation, employing an a priori estimate of a prior system state and an a posteriori estimate of a current system state, and to update the error covariance matrix.

13. The apparatus according to claim 8 , wherein the at least one automated processor is further configured to fit a curve on values of the dataset by a statistical process responsive to a curve-fitting error, wherein:

the approximation of the first derivative of said at least one physiological parameter is done by taking the first derivative of the curve; and

the approximation of the at least one derivative of at least second order of said at least one physiological parameter is done by taking the second derivative of the curve.

14. The apparatus according to claim 1 , wherein the at least one automated processor is configured to perform a z-transform on the sequence of values to determine a frequency domain version.

15. The apparatus according to claim 1 , wherein the adaptive at least second order predictive model comprises an artificial neural network.

16. The apparatus according to claim 8 , wherein the at least one automated processor is further configured to set at least one threshold level of the predicted future state, and to produce an output dependent on a relationship of the predicted state and said at least one threshold level of the predicted state.

17. The apparatus according to claim 1 , wherein: the apparatus is wearable; and the physiological parameter is derived from at least one of a motion or inertial sensor.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 17, 2020
From: POLTORAK, ALEXANDER I, DR.
To: POLTORAK TECHNOLOGIES, LLC
Reel/Frame 053517/0492 →
Continuity (2)
Provisional Application 62888213 · Aug 16, 2019
Related Publication 20210045640A1 · Feb 18, 2021
References Cited (400)
US 2269385A · Lee · 1942 [cited by applicant]
US 2342944A · Kretske · 1944 [cited by applicant]
US 2865116A · Messer · 1958 [cited by applicant]
US 3966877A · Kalach et al. · 1976 [cited by applicant]
US 4209871A · Ernest et al. · 1980 [cited by applicant]
US 4589078A · Rosenberg · 1986 [cited by applicant]
US 4660242A · Vornberger et al. · 1987 [cited by applicant]
US 4679269A · Becka et al. · 1987 [cited by applicant]
US 4763282A · Rosenberg · 1988 [cited by applicant]
US 4829932A · Bennett · 1989 [cited by applicant]
US 4866802A · Stein et al. · 1989 [cited by applicant]
US 5216594A · White et al. · 1993 [cited by applicant]
US 5341229A · Rowan · 1994 [cited by applicant]
US 5373651A · Wood · 1994 [cited by applicant]
US 5615111A · Raskas et al. · 1997 [cited by applicant]
US 5626140A · Feldman et al. · 1997 [cited by applicant]
US 5629848A · Repperger et al. · 1997 [cited by applicant]
US 5642096A · Leyerer et al. · 1997 [cited by applicant]
US 5694142A · Dumoulin et al. · 1997 [cited by applicant]
US 5720200A · Anderson et al. · 1998 [cited by applicant]
US 5764518A · Collins · 1998 [cited by applicant]
US 5794361A · Sadler · 1998 [cited by applicant]
US 5850352A · Moezzi et al. · 1998 [cited by applicant]
US 6001067A · Shults et al. · 1999 [cited by applicant]
US 6157850A · Diab et al. · 2000 [cited by applicant]
US 6230501B1 · Bailey, Sr. et al. · 2001 [cited by applicant]
US 6236872B1 · Diab et al. · 2001 [cited by applicant]
US 6379669B1 · Sinha · 2002 [cited by applicant]
US 6424847B1 · Mastrototaro et al. · 2002 [cited by applicant]
US 6453195B1 · Thompson · 2002 [cited by applicant]
US 6477395B2 · Schulman et al. · 2002 [cited by applicant]
US 6484046B1 · Say et al. · 2002 [cited by applicant]
US 6512939B1 · Colvin et al. · 2003 [cited by applicant]
US 6558351B1 · Steil et al. · 2003 [cited by applicant]
US 6563423B2 · Smith · 2003 [cited by applicant]
US 6565509B1 · Say et al. · 2003 [cited by applicant]
US 6567259B2 · Stevenson et al. · 2003 [cited by applicant]
US 6572545B2 · Knobbe et al. · 2003 [cited by applicant]
US 6575905B2 · Knobbe et al. · 2003 [cited by applicant]
US 6579690B1 · Bonnecaze et al. · 2003 [cited by applicant]
US 6595929B2 · Stivoric et al. · 2003 [cited by applicant]
US 6675049B2 · Thompson et al. · 2004 [cited by applicant]
US 6768246B2 · Pelrine et al. · 2004 [cited by applicant]
US 6788200B1 · Jamel et al. · 2004 [cited by applicant]
US 6817979B2 · Nihtila · 2004 [cited by applicant]
US 6833039B2 · Andersen et al. · 2004 [cited by applicant]
US 6843578B1 · Cheung · 2005 [cited by applicant]
US 6865825B2 · Bailey, Sr. et al. · 2005 [cited by applicant]
US 6931327B2 · Goode, Jr. et al. · 2005 [cited by applicant]
US 6949066B2 · Bearnson et al. · 2005 [cited by applicant]
US 7010869B1 · Ellis, III · 2006 [cited by applicant]
US 7020508B2 · Stivoric et al. · 2006 [cited by applicant]
US 7044911B2 · Drinan et al. · 2006 [cited by applicant]
US 7059070B2 · Omstead et al. · 2006 [cited by applicant]
US 7070398B2 · Olsen et al. · 2006 [cited by applicant]
US 7097662B2 · Evans, III et al. · 2006 [cited by applicant]
US 7107706B1 · Bailey, Sr. et al. · 2006 [cited by applicant]
US 7108659B2 · Ross et al. · 2006 [cited by applicant]
US 7149320B2 · Haykin et al. · 2006 [cited by applicant]
US 7167743B2 · Heruth et al. · 2007 [cited by applicant]
US 7172897B2 · Blackburn et al. · 2007 [cited by applicant]
US 7188439B2 · DiBenedetto et al. · 2007 [cited by applicant]
US 7204041B1 · Bailey, Sr. et al. · 2007 [cited by applicant]
US 7215986B2 · Diab et al. · 2007 [cited by applicant]
US 7219449B1 · Hoffberg et al. · 2007 [cited by applicant]
US 7225565B2 · DiBenedetto et al. · 2007 [cited by applicant]
US 7231254B2 · DiLorenzo · 2007 [cited by applicant]
US 7261690B2 · Teller et al. · 2007 [cited by applicant]
US 7265666B2 · Daniel · 2007 [cited by applicant]
US 7267665B2 · Steil et al. · 2007 [cited by applicant]
US 7273457B2 · Penner · 2007 [cited by applicant]
US 7280870B2 · Nurmikko et al. · 2007 [cited by applicant]
US 7285090B2 · Stivoric et al. · 2007 [cited by applicant]
US 7291114B2 · Mault · 2007 [cited by applicant]
US 7310544B2 · Brister et al. · 2007 [cited by applicant]
US 7312087B2 · Duong et al. · 2007 [cited by applicant]
US 7313440B2 · Miesel · 2007 [cited by applicant]
US 7330760B2 · Heruth et al. · 2008 [cited by applicant]
US 7333013B2 · Berger · 2008 [cited by applicant]
US 7334350B2 · Ellis, III · 2008 [cited by applicant]
US 7354420B2 · Steil et al. · 2008 [cited by applicant]
US 7366572B2 · Heruth et al. · 2008 [cited by applicant]
US 7371825B2 · Das et al. · 2008 [cited by applicant]
US 7392079B2 · Donoghue et al. · 2008 [cited by applicant]
US 7395113B2 · Heruth et al. · 2008 [cited by applicant]
US 7395614B1 · Bailey, Sr. et al. · 2008 [cited by applicant]
US 7402153B2 · Steil et al. · 2008 [cited by applicant]
US 7404263B2 · Guzman · 2008 [cited by applicant]
US 7407484B2 · Korman · 2008 [cited by applicant]
US 7409256B2 · Lin et al. · 2008 [cited by applicant]
US 7414534B1 · Kroll et al. · 2008 [cited by applicant]
US 7414611B2 · Liberty · 2008 [cited by applicant]
US 7426873B1 · Kholwadwala et al. · 2008 [cited by applicant]
US 7447545B2 · Heruth et al. · 2008 [cited by applicant]
US 7463142B2 · Lindsay · 2008 [cited by applicant]
US 7489298B2 · Liberty et al. · 2009 [cited by applicant]
US 7489299B2 · Liberty et al. · 2009 [cited by applicant]
US 7491181B2 · Heruth et al. · 2009 [cited by applicant]
US 7493230B2 · Schwartz et al. · 2009 [cited by applicant]
US 7497037B2 · Vick et al. · 2009 [cited by applicant]
US 7506460B2 · DiBenedetto et al. · 2009 [cited by applicant]
US 7519406B2 · Blank et al. · 2009 [cited by applicant]
US 7519512B2 · Spence et al. · 2009 [cited by applicant]
US 7535456B2 · Liberty et al. · 2009 [cited by applicant]
US 7542803B2 · Heruth et al. · 2009 [cited by applicant]
US 7561919B2 · Shalev et al. · 2009 [cited by applicant]
US 7562468B2 · Ellis, III · 2009 [cited by applicant]
US RE40879E · Jamel et al. · 2009 [cited by applicant]
US 7577475B2 · Cosentino et al. · 2009 [cited by applicant]
US 7579946B2 · Case, Jr. · 2009 [cited by applicant]
US 7590453B2 · Heruth et al. · 2009 [cited by applicant]
US 7590455B2 · Heruth et al. · 2009 [cited by applicant]
US 7598878B2 · Goldreich · 2009 [cited by applicant]
US 7607243B2 · Berner, Jr. et al. · 2009 [cited by applicant]
US 7610094B2 · Stahmann et al. · 2009 [cited by applicant]
US 7614166B2 · Vick et al. · 2009 [cited by applicant]
US 7616991B2 · Mann et al. · 2009 [cited by applicant]
US 7621876B2 · Hoctor et al. · 2009 [cited by applicant]
US 7623919B2 · Goetz et al. · 2009 [cited by applicant]
US 7623928B2 · DiLorenzo · 2009 [cited by applicant]
US 7630755B2 · Stahmann et al. · 2009 [cited by applicant]
US 7631382B2 · DiBenedetto et al. · 2009 [cited by applicant]
US RE41087E · Jamel et al. · 2010 [cited by applicant]
US 7641619B2 · Penner · 2010 [cited by applicant]
US RE41102E · Jamel et al. · 2010 [cited by applicant]
US RE41122E · Jamel et al. · 2010 [cited by applicant]
US 7671599B1 · Tan et al. · 2010 [cited by applicant]
US 7676960B2 · DiBenedetto et al. · 2010 [cited by applicant]
US 7676961B2 · DiBenedetto et al. · 2010 [cited by applicant]
US 7695512B2 · Lashinski et al. · 2010 [cited by applicant]
US 7697994B2 · VanDanacker · 2010 [cited by applicant]
US 7707742B2 · Ellis, III · 2010 [cited by applicant]
US 7713923B2 · Genove et al. · 2010 [cited by applicant]
US 7716008B2 · Ohta · 2010 [cited by applicant]
US 7717848B2 · Heruth et al. · 2010 [cited by applicant]
US 7727143B2 · Birk et al. · 2010 [cited by applicant]
US 7735351B2 · Profit et al. · 2010 [cited by applicant]
US 7758523B2 · Collings et al. · 2010 [cited by applicant]
US 7761261B2 · Shmueli et al. · 2010 [cited by applicant]
US 7765005B2 · Stevenson · 2010 [cited by applicant]
US 7765012B2 · Gerber · 2010 [cited by applicant]
US 7774155B2 · Sato et al. · 2010 [cited by applicant]
US 7775993B2 · Heruth et al. · 2010 [cited by applicant]
US 7780590B2 · Birk et al. · 2010 [cited by applicant]
US 7782192B2 · Jeckelmann et al. · 2010 [cited by applicant]
US 7783442B2 · Mueller, Jr. et al. · 2010 [cited by applicant]
US 7787946B2 · Stahmann et al. · 2010 [cited by applicant]
US 7787958B2 · Stevenson · 2010 [cited by applicant]
US 7792583B2 · Miesel et al. · 2010 [cited by applicant]
US 7793430B2 · Ellis · 2010 [cited by applicant]
US 7794101B2 · Galica et al. · 2010 [cited by applicant]
US 7801591B1 · Shusterman · 2010 [cited by applicant]
US 7805196B2 · Miesel et al. · 2010 [cited by applicant]
US 7806886B2 · Kanderian, Jr. et al. · 2010 [cited by applicant]
US 7813778B2 · Benaron et al. · 2010 [cited by applicant]
US 7816632B2 · Bourke, III et al. · 2010 [cited by applicant]
US 7819909B2 · Goetz et al. · 2010 [cited by applicant]
US 7825794B2 · Janetis et al. · 2010 [cited by applicant]
US 7842092B2 · Otto et al. · 2010 [cited by applicant]
US 7848819B2 · Goetz et al. · 2010 [cited by applicant]
US 7853329B2 · DiLorenzo · 2010 [cited by applicant]
US 7859540B2 · Dariush · 2010 [cited by applicant]
US 7860676B2 · Sheng et al. · 2010 [cited by applicant]
US 7876228B2 · Kroll et al. · 2011 [cited by applicant]
US 7877224B2 · Ohta · 2011 [cited by applicant]
US 7881798B2 · Miesel et al. · 2011 [cited by applicant]
US 7885712B2 · Goetz et al. · 2011 [cited by applicant]
US 7890055B1 · Stein · 2011 [cited by applicant]
US 7904149B2 · Gerber · 2011 [cited by applicant]
US 7908000B2 · Shalev · 2011 [cited by applicant]
US 7908013B2 · Miesel et al. · 2011 [cited by applicant]
US 7916013B2 · Stevenson · 2011 [cited by applicant]
US 7927216B2 · Ikeda et al. · 2011 [cited by applicant]
US 7930035B2 · DiLorenzo · 2011 [cited by applicant]
US 7930131B2 · Ridenour et al. · 2011 [cited by applicant]
US 7931535B2 · Ikeda et al. · 2011 [cited by applicant]
US 7932825B2 · Berger · 2011 [cited by applicant]
US 7942745B2 · Ikeda et al. · 2011 [cited by applicant]
US 7953488B2 · Casavant et al. · 2011 [cited by applicant]
US 7956162B2 · Chahal et al. · 2011 [cited by applicant]
US 7959567B2 · Stivoric et al. · 2011 [cited by applicant]
US 7966075B2 · Johnson et al. · 2011 [cited by applicant]
US 7970470B2 · Hartley et al. · 2011 [cited by applicant]
US 7974696B1 · DiLorenzo · 2011 [cited by applicant]
US 7978062B2 · LaLonde et al. · 2011 [cited by applicant]
US 7981025B2 · Pool et al. · 2011 [cited by applicant]
US 7983435B2 · Moses · 2011 [cited by applicant]
US 7983763B2 · Stevenson et al. · 2011 [cited by applicant]
US 7996158B2 · Hayter et al. · 2011 [cited by applicant]
US 8000801B2 · Stevenson et al. · 2011 [cited by applicant]
US 8005539B2 · Burnes et al. · 2011 [cited by applicant]
US 8010189B2 · Shalev · 2011 [cited by applicant]
US 8015732B2 · Berner, Jr. et al. · 2011 [cited by applicant]
US 8021299B2 · Miesel et al. · 2011 [cited by applicant]
US 8028443B2 · Case, Jr. · 2011 [cited by applicant]
US 8032224B2 · Miesel et al. · 2011 [cited by applicant]
US 8033999B2 · Xi · 2011 [cited by applicant]
US 8036736B2 · Snyder et al. · 2011 [cited by applicant]
US 8038613B2 · Stupp et al. · 2011 [cited by applicant]
US 8041536B2 · Ohta · 2011 [cited by applicant]
US 8055330B2 · Egozi · 2011 [cited by applicant]
US 8055334B2 · Savage et al. · 2011 [cited by applicant]
US 8055348B2 · Heruth et al. · 2011 [cited by applicant]
US 8056268B2 · DiBenedetto et al. · 2011 [cited by applicant]
US 8072424B2 · Liberty · 2011 [cited by applicant]
US 8078278B2 · Penner · 2011 [cited by applicant]
US 8078282B2 · Nycz · 2011 [cited by applicant]
US 8079518B2 · Turner et al. · 2011 [cited by applicant]
US 8081925B2 · Parramon et al. · 2011 [cited by applicant]
US 8086250B2 · Janetis et al. · 2011 [cited by applicant]
US 8086302B2 · Kracker · 2011 [cited by applicant]
US 8089458B2 · Barney et al. · 2012 [cited by applicant]
US 8093991B2 · Stevenson et al. · 2012 [cited by applicant]
US 8103471B2 · Hayter · 2012 [cited by applicant]
US 8103802B2 · Lay et al. · 2012 [cited by applicant]
US 8114021B2 · Robertson et al. · 2012 [cited by applicant]
US 8114345B2 · Dlugos, Jr. et al. · 2012 [cited by applicant]
US 8114964B2 · Das et al. · 2012 [cited by applicant]
US 8115618B2 · Robertson et al. · 2012 [cited by applicant]
US 8121691B2 · Gerber et al. · 2012 [cited by applicant]
US 8121694B2 · Molnar et al. · 2012 [cited by applicant]
US 8123696B2 · Childre et al. · 2012 [cited by applicant]
US 8127470B2 · Connor · 2012 [cited by applicant]
US 8135473B2 · Miesel et al. · 2012 [cited by applicant]
US 8137195B2 · Penzias · 2012 [cited by applicant]
US 8137269B2 · Sheikhzadeh-Nadjar et al. · 2012 [cited by applicant]
US 8140161B2 · Willerton et al. · 2012 [cited by applicant]
US 8141276B2 · Ellis · 2012 [cited by applicant]
US 8152710B2 · Dlugos, Jr. et al. · 2012 [cited by applicant]
US 8157651B2 · Ohta et al. · 2012 [cited by applicant]
US 8157731B2 · Teller et al. · 2012 [cited by applicant]
US 8160273B2 · Visser et al. · 2012 [cited by applicant]
US 8160669B2 · Brauker et al. · 2012 [cited by applicant]
US 8160695B2 · Dacey, Jr. et al. · 2012 [cited by applicant]
US 8160702B2 · Mann et al. · 2012 [cited by applicant]
US 8164567B1 · Barney et al. · 2012 [cited by applicant]
US 8165691B2 · Ellingson et al. · 2012 [cited by applicant]
US 8165893B1 · Goldberg et al. · 2012 [cited by applicant]
US 8169406B2 · Barney et al. · 2012 [cited by applicant]
US 8172459B2 · Abreu · 2012 [cited by applicant]
US 8174378B2 · Richman et al. · 2012 [cited by applicant]
US 8174395B2 · Samuelsson et al. · 2012 [cited by applicant]
US 8180446B2 · Dacey, Jr. et al. · 2012 [cited by applicant]
US 8180447B2 · Dacey, Jr. et al. · 2012 [cited by applicant]
US 8180591B2 · Yuen et al. · 2012 [cited by applicant]
US 8180592B2 · Yuen et al. · 2012 [cited by applicant]
US 8184097B1 · Barney et al. · 2012 [cited by applicant]
US 8185181B2 · Feldman et al. · 2012 [cited by applicant]
US 8186081B2 · Wilson, III et al. · 2012 [cited by applicant]
US 8190253B2 · Heruth et al. · 2012 [cited by applicant]
US 8192406B2 · Wells et al. · 2012 [cited by applicant]
US 8197454B2 · Mann et al. · 2012 [cited by applicant]
US 8200342B2 · Stevenson et al. · 2012 [cited by applicant]
US 8202260B2 · Mann et al. · 2012 [cited by applicant]
US 8204590B2 · Sambelashvili et al. · 2012 [cited by applicant]
US 8204597B2 · Gerber et al. · 2012 [cited by applicant]
US 8205356B2 · Ellis · 2012 [cited by applicant]
US 8207316B1 · Bentwich · 2012 [cited by applicant]
US 8214045B2 · Kronich et al. · 2012 [cited by applicant]
US 8216139B2 · Brauker et al. · 2012 [cited by applicant]
US 8217946B2 · Halpern et al. · 2012 [cited by applicant]
US 8226493B2 · Briggs et al. · 2012 [cited by applicant]
US 8233958B2 · Brauker et al. · 2012 [cited by applicant]
US 8233959B2 · Kamath et al. · 2012 [cited by applicant]
US 8233976B2 · Dacey, Jr. et al. · 2012 [cited by applicant]
US 8234798B2 · DiBenedetto et al. · 2012 [cited by applicant]
US 8237657B2 · Liberty et al. · 2012 [cited by applicant]
US 8239166B2 · Hayter et al. · 2012 [cited by applicant]
US 8246533B2 · Chang et al. · 2012 [cited by applicant]
US 8246563B2 · Wariar · 2012 [cited by applicant]
US 8248367B1 · Barney et al. · 2012 [cited by applicant]
US 8249708B2 · Krause et al. · 2012 [cited by applicant]
US 8250782B2 · Callahan et al. · 2012 [cited by applicant]
US 8251061B2 · Lee et al. · 2012 [cited by applicant]
US 8251903B2 · LeBoeuf et al. · 2012 [cited by applicant]
US 8251906B2 · Brauker et al. · 2012 [cited by applicant]
US 8251946B2 · Bardy · 2012 [cited by applicant]
US 8257259B2 · Brauker et al. · 2012 [cited by applicant]
US 8257729B2 · Schmitz et al. · 2012 [cited by applicant]
US 8258941B2 · Case, Jr. · 2012 [cited by applicant]
US 8260393B2 · Kamath et al. · 2012 [cited by applicant]
US 8260412B2 · Krause et al. · 2012 [cited by applicant]
US 8260422B2 · Ellingson et al. · 2012 [cited by applicant]
US 8260558B2 · Hayter et al. · 2012 [cited by applicant]
US 8261468B2 · Ellis, III · 2012 [cited by applicant]
US 8265723B1 · McHale et al. · 2012 [cited by applicant]
US 8265725B2 · Brauker et al. · 2012 [cited by applicant]
US 8265771B2 · Donofrio et al. · 2012 [cited by applicant]
US 8267786B2 · Ikeda · 2012 [cited by applicant]
US 8269635B2 · Kroll et al. · 2012 [cited by applicant]
US 8269636B2 · Kroll et al. · 2012 [cited by applicant]
US 8270938B2 · Flippo et al. · 2012 [cited by applicant]
US 8271072B2 · Houben et al. · 2012 [cited by applicant]
US 8273032B2 · Carney et al. · 2012 [cited by applicant]
US 8275437B2 · Brauker et al. · 2012 [cited by applicant]
US 8277741B2 · McCabe · 2012 [cited by applicant]
US 8280475B2 · Brister et al. · 2012 [cited by applicant]
US 8282549B2 · Brauker et al. · 2012 [cited by applicant]
US 8287520B2 · Drew et al. · 2012 [cited by applicant]
US 8290561B2 · Brauker et al. · 2012 [cited by applicant]
US 8290596B2 · Wei et al. · 2012 [cited by applicant]
US 8291614B2 · Ellis · 2012 [cited by applicant]
US 8295933B2 · Gerber et al. · 2012 [cited by applicant]
US 8301219B2 · Chen et al. · 2012 [cited by applicant]
US 8301243B2 · Stevenson et al. · 2012 [cited by applicant]
US 8306610B2 · Mirow · 2012 [cited by applicant]
US 8306766B2 · Mueller, Jr. et al. · 2012 [cited by applicant]
US 8308563B2 · Ikeda et al. · 2012 [cited by applicant]
US 8308661B2 · Miesel et al. · 2012 [cited by applicant]
US 8310336B2 · Muhsin et al. · 2012 [cited by applicant]
US 8311749B2 · Brauker et al. · 2012 [cited by applicant]
US 8311769B2 · Yuen et al. · 2012 [cited by applicant]
US 8311770B2 · Yuen et al. · 2012 [cited by applicant]
US 8313379B2 · Ikeda et al. · 2012 [cited by applicant]
US 8321003B2 · Zhang et al. · 2012 [cited by applicant]
US 8321032B2 · Frysz et al. · 2012 [cited by applicant]
US 8321149B2 · Brauker et al. · 2012 [cited by applicant]
US 8323232B2 · Bardy · 2012 [cited by applicant]
US 8326435B2 · Stevenson · 2012 [cited by applicant]
US 8328420B2 · Abreu · 2012 [cited by applicant]
US 8332038B2 · Heruth et al. · 2012 [cited by applicant]
US 8335568B2 · Heruth et al. · 2012 [cited by applicant]
US 8337431B2 · Heruth et al. · 2012 [cited by applicant]
US 8348882B2 · Bardy · 2013 [cited by applicant]
US 8348886B2 · Kanderian, Jr. et al. · 2013 [cited by applicant]
US 8348923B2 · Kanderian, Jr. et al. · 2013 [cited by applicant]
US 8355783B2 · Goetz et al. · 2013 [cited by applicant]
US 8359095B2 · Hedberg et al. · 2013 [cited by applicant]
US 8359545B2 · Pixley et al. · 2013 [cited by applicant]
US 8368648B2 · Barney et al. · 2013 [cited by applicant]
US 8373556B2 · LaLonde et al. · 2013 [cited by applicant]
US 8373659B2 · Barney et al. · 2013 [cited by applicant]
US 8374667B2 · Brauker et al. · 2013 [cited by applicant]
US 8374697B2 · Berger · 2013 [cited by applicant]
US 8376943B2 · Kovach et al. · 2013 [cited by applicant]
US 8384668B2 · Barney et al. · 2013 [cited by applicant]
US 8385971B2 · Rhoads et al. · 2013 [cited by applicant]
US 8386004B2 · Kamath et al. · 2013 [cited by applicant]
US 8386008B2 · Yuen et al. · 2013 [cited by applicant]
US 8388347B2 · Beville · 2013 [cited by applicant]
US 8388530B2 · Shusterman · 2013 [cited by applicant]
US 8388544B2 · Hoctor et al. · 2013 [cited by applicant]
US 8389286B2 · Chahal et al. · 2013 [cited by applicant]
US 8395498B2 · Gaskill et al. · 2013 [cited by applicant]
US 8396554B2 · Miesel et al. · 2013 [cited by applicant]
US 8396557B2 · DiLorenzo · 2013 [cited by applicant]
US 8398546B2 · Pacione et al. · 2013 [cited by applicant]
US 8406893B2 · Krause et al. · 2013 [cited by applicant]
US 8407022B2 · Sheng et al. · 2013 [cited by applicant]
US 8409003B2 · Ikeda · 2013 [cited by applicant]
US 8410940B2 · Samuelsson et al. · 2013 [cited by applicant]
US 8412352B2 · Griswold et al. · 2013 [cited by applicant]
US 8417311B2 · Rule · 2013 [cited by applicant]
US 8419650B2 · Cosentino et al. · 2013 [cited by applicant]
US 8421822B2 · Odland et al. · 2013 [cited by applicant]
US 8428744B2 · Stancer et al. · 2013 [cited by applicant]
US 8430753B2 · Ikeda et al. · 2013 [cited by applicant]
US 8433395B1 · Brockway et al. · 2013 [cited by applicant]
US 8435186B2 · Hettrick et al. · 2013 [cited by applicant]
US 8435738B2 · Holmes · 2013 [cited by applicant]
US 8436810B2 · Langereis et al. · 2013 [cited by applicant]
US 8437980B2 · Yuen et al. · 2013 [cited by applicant]
US 8438038B2 · Cosentino et al. · 2013 [cited by applicant]
US 8444560B2 · Hayter et al. · 2013 [cited by applicant]
US 8444653B2 · Nycz et al. · 2013 [cited by applicant]
US 8447265B2 · Flippo et al. · 2013 [cited by applicant]
US 8447401B2 · Miesel et al. · 2013 [cited by applicant]
US 8447403B2 · Sharma et al. · 2013 [cited by applicant]
US 8447404B2 · Sharma et al. · 2013 [cited by applicant]
US 8452366B2 · Gilland · 2013 [cited by applicant]
US 8452394B2 · Burnes et al. · 2013 [cited by applicant]
US 8454552B2 · Bardy · 2013 [cited by applicant]
US 8457727B2 · Qu · 2013 [cited by applicant]
US 8457757B2 · Cauller et al. · 2013 [cited by applicant]
US 8457760B2 · Johnson et al. · 2013 [cited by applicant]
US 8460189B2 · Libbus et al. · 2013 [cited by applicant]
US 8461979B2 · Case, Jr. · 2013 [cited by applicant]
US 8463576B2 · Yuen et al. · 2013 [cited by applicant]
US 8463577B2 · Yuen et al. · 2013 [cited by applicant]
US 8467904B2 · Dariush · 2013 [cited by applicant]
US 8469886B2 · Brauker et al. · 2013 [cited by applicant]
US 8473245B2 · Ohta · 2013 [cited by applicant]
US 8475275B2 · Weston et al. · 2013 [cited by applicant]
US 8475739B2 · Holmes et al. · 2013 [cited by applicant]
US 8478378B2 · Lal et al. · 2013 [cited by applicant]
US 8478389B1 · Brockway et al. · 2013 [cited by applicant]
US 8478557B2 · Hayter et al. · 2013 [cited by applicant]
US 8483840B2 · Stevenson et al. · 2013 [cited by applicant]
US 8484153B2 · Mott et al. · 2013 [cited by applicant]
US 8484270B2 · Kurtz et al. · 2013 [cited by applicant]
US 8485979B2 · Giftakis et al. · 2013 [cited by applicant]
US 8486070B2 · Morgan et al. · 2013 [cited by applicant]
US 8491389B2 · Weston et al. · 2013 [cited by applicant]
US 8493187B2 · Rowland et al. · 2013 [cited by applicant]
US 8494829B2 · Teixeira · 2013 [cited by applicant]
US 8496657B2 · Bonutti et al. · 2013 [cited by applicant]
US RE44408E · Lindsay · 2013 [cited by applicant]
US 8499476B2 · Berner, Jr. et al. · 2013 [cited by applicant]
US 8509893B2 · Xiao et al. · 2013 [cited by applicant]
US 8509913B2 · Johnson et al. · 2013 [cited by applicant]
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