Implantable miniaturized and soft wireless sensing device to monitor tissue and bone deformation
The present invention features a sensor implant that can adhere to bone. The sensing device is capable of sensing bone strains and reporting them as well as loads passing through bone for extended periods of time. The sensor implant can also be used to monitor bone growth for bone segmental repair of long bones or to monitor changes in bone characteristics of patients with osteoporosis. The present technology has the potential to give physicians the ability to predict when a patient with osteoporosis has an impending fracture and thus be able to intervene and prevent further damage.
1 . An implantable sensor device ( 100 ) for monitoring of the musculoskeletal system, said implantable sensor device ( 100 ) comprising:
a) a strain gauge ( 110 );
b) an analog front end ( 120 ) operatively coupled to the strain gauge ( 110 ), wherein the analog front end ( 120 ) amplifies information from the sensor;
c) a processor ( 130 ) operatively coupled to the analog front end ( 120 ), wherein the processor ( 130 ) digitalizes the information from the analog front end;
d) a radiofrequency (RF) transmitter ( 140 ) operatively coupled to the processor ( 130 ), wherein the RF transmitter sends information to an external reader ( 150 ); and
e) an energy harvesting system ( 160 ) operatively coupled to the RF transmitter ( 140 ), wherein the energy harvesting system ( 160 ) harvests energy from the external reader ( 150 );
wherein the implantable sensor device ( 100 ) is configured to be permanently attached to a bone surface via calcium ceramic particle coating, and wherein the strain gauge ( 110 ) is configured to interface with the bone surface and measures changes in bone strain.
2 . The sensor device ( 100 ) of claim 1 , further comprising a thermistor operatively coupled to the analog front end ( 120 ), wherein the thermistor is a negative temperature coefficient (NTC) thermistor.
3 . The sensor device ( 100 ) of claim 1 , further comprising a light emitting diode (LED) operatively coupled to the processor ( 130 ), wherein the LED is a microscale inorganic light-emitting diode.
4 . The sensor device ( 100 ) of claim 1 , wherein a biointerface of the sensor device ( 100 ) comprises the strain gauge ( 110 ), a thermistor and an LED.
5 . The sensor device ( 100 ) of claim 4 , wherein the biointerface enables simultaneous recording of local biophysical signals and on-demand delivery of exogenous stimulation, wherein the local biophysical signals comprise bone strain and/or local temperature, and wherein the exogenous stimulation comprises an optical stimulation to the bone and surrounding tissues.
6 . The sensor device ( 100 ) of claim 1 , wherein bone strain and/or load changes measured by the sensor gauge ( 110 ) are converted to electronic signals by the processor ( 130 ), and the electronic signals are transmitted by the RF transmitter ( 140 ) to the external reader ( 150 ).
7 . The sensor device ( 100 ) of claim 1 , wherein the external reader ( 150 ) is configured to be external to a body in which the sensor is implanted, wherein the external reader ( 150 ) is a smart device.
8 . The sensor device ( 100 ) of claim 1 , where the sensor device ( 100 ) is used to determine bone stiffness, determine the risk of a bone fracture, monitor arthrodesis, monitor fracture healing, diagnose osteoporosis, treat osteoporosis, or a combination thereof.
9 . The sensor device ( 100 ) of claim 8 , wherein the device ( 100 ) is used with other components to treat osteoporosis, wherein the other components comprise another implanted device that allows the release of chemicals or molecules that are known to induce new bone formation, wherein the chemicals or molecules known to induce new bone formation comprise TGF-beta 1, or BMP-2 or BMP-7 or a combination thereof.