IP Library › Granted Patent US 12,268,846
Granted Patent B2
US 12,268,846 · App. 18/638,352 · Granted Apr 8, 2025

Regulating delivery of insulin to a body of a user by a fluid delivery device

Inventors: Benyamin Grosman (Winnetka, CA); Di Wu (Palo Alto, CA); Anirban Roy (Agoura Hills, CA); Neha J. Parikh (Pleasanton, CA)
Assignee: MEDTRONIC MINIMED, INC.
A61M5/1723A61B5/14503A61B5/14532A61B5/4839A61B5/746A61M5/14244G16H20/17G16Z99/00A61M2005/14208A61M2205/52A61M2230/005A61M2230/201
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,268,846
App. No.
18/638,352
Granted
Apr 8, 2025
Kind
B2
Abstract

Techniques related to temporary setpoint values are disclosed. The techniques may involve causing operation of a fluid delivery device in a closed-loop mode for automatically delivering fluid based on a difference between a first setpoint value and an analyte concentration value during operation of the fluid delivery device in the closed-loop mode. Additionally, the techniques may involve obtaining a second setpoint value. The second setpoint value may be a temporary setpoint value to be used for a period of time to regulate fluid delivery, and the second setpoint value may be greater than the first setpoint value. The techniques may further involve causing operation of the fluid delivery device for automatically reducing fluid delivery for the period of time based on the second setpoint value.

Claims (38)

1. A method of operating an insulin infusion device to regulate delivery of insulin to a body of a user, the method comprising:

obtaining, from a continuous glucose sensor, sensor glucose (SG) values for the user;

operating in a first mode of operation or a second mode of operation, wherein the mode of operation is dependent on one or more of: a sensor underread condition being met, a sensor overread condition being met, the SG values for the user, a minimum lower limit of insulin to be delivered (UMIN) time limit being exceeded, or a maximum upper limit of insulin to be delivered (UMAX) limit being exceeded; and

automatically operating the insulin infusion device to control delivery of insulin from the insulin infusion device to the body of the user, in accordance with the mode of operation.

2. The method of claim 1 , further comprising:

determining a correction bolus dosage while in the first mode of operation; and

causing delivery of insulin at the correction bolus dosage.

3. The method of claim 1 , further comprising:

responsive to detecting the UMAX time limit being exceeded or the UMIN time limit being exceeded, causing an alert to be presented to the user; and

operating in the second mode of operation.

4. The method of claim 1 , wherein operating in the first mode of operation or the second mode of operation dependent on the SG values for the user comprises determining a difference between a model-predicted glucose value for the user and the SG values for the user.

5. The method of claim 1 , wherein operating in the first mode of operation or the second mode of operation is dependent on whether SG values for the user have not been received for more than a predetermined threshold of time.

6. The method of claim 5 , further comprising transitioning to the second mode of operation responsive to the SG values for the user having not been received for more than the predetermined threshold of time, wherein the second mode of operation corresponds to a safe basal delivery mode of operation.

7. The method of claim 6 , further comprising transitioning to a third mode of operation responsive to operation of the insulin infusion device in the safe basal delivery mode of operation for more than a second predetermined threshold of time, wherein the third mode of operation comprises an open-loop mode of operation.

8. The method of claim 5 , wherein determining whether the SG values for the user have not been received for more than a predetermined threshold of time is based on data packets received at the insulin infusion device from the continuous glucose sensor.

9. The method of claim 1 , wherein the sensor underread condition and/or the sensor overread condition are determined based on a comparison of the SG values for the user to model-predicted glucose values for the user.

10. A system comprising:

one or more processors; and

one or more processor-readable media storing instructions which, when executed by one or more processors, cause performance of:

obtaining, from a continuous glucose sensor, sensor glucose (SG) values for a user;

operating in a first mode of operation or a second mode of operation, wherein the mode of operation is dependent on one or more of: a sensor underread condition being met, a sensor overread condition being met, the SG values for the user, a minimum lower limit of insulin to be delivered (UMIN) time limit being exceeded, or a maximum upper limit of insulin to be delivered (UMAX) limit being exceeded; and

automatically operating an insulin infusion device to control delivery of insulin from the insulin infusion device to a body of the user, in accordance with the mode of operation.

11. The system of claim 10 , wherein the instructions further cause performance of:

determining a correction bolus dosage while in the first mode of operation; and

causing delivery of insulin at the correction bolus dosage.

12. The system of claim 10 , wherein the instructions further cause performance of:

responsive to detecting the UMAX time limit being exceeded or the UMIN time limit being exceeded, causing an alert to be presented to the user; and

operating in the second mode of operation.

13. The system of claim 10 , wherein operating in the first mode of operation or the second mode of operation dependent on the SG values for the user comprises determining a difference between a model-predicted glucose value for the user and the SG values for the user.

14. The system of claim 10 , wherein operating in the first mode of operation or the second mode of operation is dependent on whether SG values for the user have not been received for more than a predetermined threshold of time.

15. The system of claim 14 , wherein the instructions further cause performance of transitioning to the second mode of operation responsive to the SG values for the user having not been received for more than the predetermined threshold of time, wherein the second mode of operation corresponds to a safe basal delivery mode of operation.

16. The system of claim 15 , wherein the instructions further cause performance of transitioning to a third mode of operation responsive to operation of the insulin infusion device in the safe basal delivery mode of operation for more than a second predetermined threshold of time, wherein the third mode of operation comprises an open-loop mode of operation.

17. The system of claim 14 , wherein determining whether the SG values for the user have not been received for more than a predetermined threshold of time is based on data packets received at the insulin infusion device from the continuous glucose sensor.

18. The system of claim 10 , wherein the sensor underread condition and/or the sensor overread condition are determined based on a comparison of the SG values for the user to model-predicted glucose values for the user.

19. A method comprising:

receiving a temporary setpoint value to be used for a specified period of time to regulate fluid delivery to a patient during operation of a fluid delivery device, wherein the temporary setpoint value is greater than a default setpoint value; and

responsive to receiving the temporary setpoint value, causing operation of the fluid delivery device to transition from a first mode of operation to a second mode of operation, wherein the second mode of operation comprises automatically delivering fluid to the patient based on a difference between the temporary setpoint value and measured glucose values of the patient.

20. The method of claim 19 , wherein automatically delivering fluid to the patient while in the second mode of operation causes a reduction in fluid delivery to the patient relative to the first mode of operation.

Assignments (2)
SECURITY INTEREST Recorded Jan 16, 2026
From: MEDTRONIC MINIMED, INC.; COMPANION MEDICAL, INC.
To: CITIBANK, N.A.
Reel/Frame 074394/0237 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2024
From: GROSMAN, BENYAMIN; WU, DI; ROY, ANIRBAN; PARIKH, NEHA J.
To: MEDTRONIC MINIMED, INC.
Reel/Frame 067166/0372 →
Continuity (8)
Continuation 18118964 · Mar 8, 2023
Continuation 16156801 · Oct 10, 2018
Continuation 15138540 · Apr 26, 2016
Continuation In Part 13870907 · Apr 25, 2013
Provisional Application 61812874 · Apr 17, 2013
Provisional Application 61694961 · Aug 30, 2012
Provisional Application 61694950 · Aug 30, 2012
Related Publication 20240277932A1 · Aug 22, 2024
References Cited (400)
US 3631847A · Hobbs, II · 1972 [cited by applicant]
US 4212738A · Henne · 1980 [cited by applicant]
US 4270532A · Franetzki et al. · 1981 [cited by applicant]
US 4282872A · Franetzki et al. · 1981 [cited by applicant]
US 4373527A · Fischell · 1983 [cited by applicant]
US 4395259A · Prestele et al. · 1983 [cited by applicant]
US 4433072A · Pusineri et al. · 1984 [cited by applicant]
US 4443218A · DeCant, Jr. et al. · 1984 [cited by applicant]
US 4494950A · Fischell · 1985 [cited by applicant]
US 4533346A · Cosgrove, Jr. et al. · 1985 [cited by applicant]
US 4542532A · McQuilkin · 1985 [cited by applicant]
US 4550731A · Batina et al. · 1985 [cited by applicant]
US 4559037A · Franetzki et al. · 1985 [cited by applicant]
US 4562751A · Nason et al. · 1986 [cited by applicant]
US 4573994A · Fischell et al. · 1986 [cited by applicant]
US 4618408A · Malavarca et al. · 1986 [cited by applicant]
US 4671288A · Gough · 1987 [cited by applicant]
US 4678408A · Nason et al. · 1987 [cited by applicant]
US 4685903A · Cable et al. · 1987 [cited by applicant]
US 4731051A · Fischell · 1988 [cited by applicant]
US 4731726A · Allen, III · 1988 [cited by applicant]
US 4755173A · Konopka et al. · 1988 [cited by applicant]
US 4781798A · Gough · 1988 [cited by applicant]
US 4803625A · Fu et al. · 1989 [cited by applicant]
US 4809697A · Causey, III et al. · 1989 [cited by applicant]
US 4826810A · Aoki · 1989 [cited by applicant]
US 4871351A · Feingold · 1989 [cited by applicant]
US 4898578A · Rubalcaba, Jr. · 1990 [cited by applicant]
US 5003298A · Havel · 1991 [cited by applicant]
US 5011468A · Lundquist et al. · 1991 [cited by applicant]
US 5019974A · Beckers · 1991 [cited by applicant]
US 5050612A · Matsumura · 1991 [cited by applicant]
US 5078683A · Sancoff et al. · 1992 [cited by applicant]
US 5080653A · Voss et al. · 1992 [cited by applicant]
US 5097122A · Colman et al. · 1992 [cited by applicant]
US 5100380A · Epstein et al. · 1992 [cited by applicant]
US 5101814A · Palti · 1992 [cited by applicant]
US 5108819A · Heller et al. · 1992 [cited by applicant]
US 5153827A · Coutre et al. · 1992 [cited by applicant]
US 5165407A · Wilson et al. · 1992 [cited by applicant]
US 5247434A · Peterson et al. · 1993 [cited by applicant]
US 5262035A · Gregg et al. · 1993 [cited by applicant]
US 5262305A · Heller et al. · 1993 [cited by applicant]
US 5264104A · Gregg et al. · 1993 [cited by applicant]
US 5264105A · Gregg et al. · 1993 [cited by applicant]
US 5284140A · Allen et al. · 1994 [cited by applicant]
US 5299571A · Mastrototaro · 1994 [cited by applicant]
US 5307263A · Brown · 1994 [cited by applicant]
US 5317506A · Coutre et al. · 1994 [cited by applicant]
US 5320725A · Gregg et al. · 1994 [cited by applicant]
US 5322063A · Allen et al. · 1994 [cited by applicant]
US 5338157A · Blomquist · 1994 [cited by applicant]
US 5339821A · Fujimoto · 1994 [cited by applicant]
US 5341291A · Roizen et al. · 1994 [cited by applicant]
US 5350411A · Ryan et al. · 1994 [cited by applicant]
US 5356786A · Heller et al. · 1994 [cited by applicant]
US 5357427A · Langen et al. · 1994 [cited by applicant]
US 5368562A · Blomquist et al. · 1994 [cited by applicant]
US 5370622A · Livingston et al. · 1994 [cited by applicant]
US 5371687A · Holmes, II et al. · 1994 [cited by applicant]
US 5376070A · Purvis et al. · 1994 [cited by applicant]
US 5390671A · Lord et al. · 1995 [cited by applicant]
US 5391250A · Cheney, II et al. · 1995 [cited by applicant]
US 5403700A · Heller et al. · 1995 [cited by applicant]
US 5411647A · Johnson et al. · 1995 [cited by applicant]
US 5482473A · Lord et al. · 1996 [cited by applicant]
US 5485408A · Blomquist · 1996 [cited by applicant]
US 5497772A · Schulman et al. · 1996 [cited by applicant]
US 5505709A · Funderburk et al. · 1996 [cited by applicant]
US 5522803A · Teissen-Simony · 1996 [cited by applicant]
US 5543326A · Heller et al. · 1996 [cited by applicant]
US 5569186A · Lord et al. · 1996 [cited by applicant]
US 5569187A · Kaiser · 1996 [cited by applicant]
US 5573506A · Vasko · 1996 [cited by applicant]
US 5582593A · Hultman · 1996 [cited by applicant]
US 5586553A · Halili et al. · 1996 [cited by applicant]
US 5593390A · Castellano et al. · 1997 [cited by applicant]
US 5593852A · Heller et al. · 1997 [cited by applicant]
US 5594638A · Iliff · 1997 [cited by applicant]
US 5609060A · Dent · 1997 [cited by applicant]
US 5626144A · Tacklind et al. · 1997 [cited by applicant]
US 5630710A · Tune et al. · 1997 [cited by applicant]
US 5643212A · Coutre et al. · 1997 [cited by applicant]
US 5660163A · Schulman et al. · 1997 [cited by applicant]
US 5660176A · Iliff · 1997 [cited by applicant]
US 5665065A · Colman et al. · 1997 [cited by applicant]
US 5665222A · Heller et al. · 1997 [cited by applicant]
US 5685844A · Marttila · 1997 [cited by applicant]
US 5687734A · Dempsey et al. · 1997 [cited by applicant]
US 5704366A · Tacklind et al. · 1998 [cited by applicant]
US 5750926A · Schulman et al. · 1998 [cited by applicant]
US 5754111A · Garcia · 1998 [cited by applicant]
US 5764159A · Neftel · 1998 [cited by applicant]
US 5772635A · Dastur et al. · 1998 [cited by applicant]
US 5779665A · Mastrototaro et al. · 1998 [cited by applicant]
US 5788669A · Peterson · 1998 [cited by applicant]
US 5791344A · Schulman et al. · 1998 [cited by applicant]
US 5800420A · Gross et al. · 1998 [cited by applicant]
US 5807315A · Van Antwerp et al. · 1998 [cited by applicant]
US 5807336A · Russo et al. · 1998 [cited by applicant]
US 5807375A · Gross et al. · 1998 [cited by applicant]
US 5814015A · Gargano et al. · 1998 [cited by applicant]
US 5822715A · Worthington et al. · 1998 [cited by applicant]
US 5832448A · Brown · 1998 [cited by applicant]
US 5840020A · Heinonen et al. · 1998 [cited by applicant]
US 5861018A · Feierbach · 1999 [cited by applicant]
US 5868669A · Iliff · 1999 [cited by applicant]
US 5871465A · Vasko · 1999 [cited by applicant]
US 5879163A · Brown et al. · 1999 [cited by applicant]
US 5885245A · Lynch et al. · 1999 [cited by applicant]
US 5897493A · Brown · 1999 [cited by applicant]
US 5899855A · Brown · 1999 [cited by applicant]
US 5904708A · Goedeke · 1999 [cited by applicant]
US 5913310A · Brown · 1999 [cited by applicant]
US 5917346A · Gord · 1999 [cited by applicant]
US 5918603A · Brown · 1999 [cited by applicant]
US 5925021A · Castellano et al. · 1999 [cited by applicant]
US 5933136A · Brown · 1999 [cited by applicant]
US 5935099A · Peterson et al. · 1999 [cited by applicant]
US 5940801A · Brown · 1999 [cited by applicant]
US 5951521A · Mastrototaro et al. · 1999 [cited by applicant]
US 5954643A · Vanantwerp et al. · 1999 [cited by applicant]
US 5956501A · Brown · 1999 [cited by applicant]
US 5960403A · Brown · 1999 [cited by applicant]
US 5965380A · Heller et al. · 1999 [cited by applicant]
US 5972199A · Heller et al. · 1999 [cited by applicant]
US 5978236A · Faberman et al. · 1999 [cited by applicant]
US 5997476A · Brown · 1999 [cited by applicant]
US 5999848A · Gord et al. · 1999 [cited by applicant]
US 5999849A · Gord et al. · 1999 [cited by applicant]
US 6009339A · Bentsen et al. · 1999 [cited by applicant]
US 6011984A · Van Antwerp et al. · 2000 [cited by applicant]
US 6017328A · Fischell et al. · 2000 [cited by applicant]
US 6032119A · Brown et al. · 2000 [cited by applicant]
US 6043437A · Schulman et al. · 2000 [cited by applicant]
US 6081736A · Colvin et al. · 2000 [cited by applicant]
US 6083710A · Heller et al. · 2000 [cited by applicant]
US 6088608A · Schulman et al. · 2000 [cited by applicant]
US 6101478A · Brown · 2000 [cited by applicant]
US 6103033A · Say et al. · 2000 [cited by applicant]
US 6119028A · Schulman et al. · 2000 [cited by applicant]
US 6120676A · Heller et al. · 2000 [cited by applicant]
US 6121009A · Heller et al. · 2000 [cited by applicant]
US 6134461A · Say et al. · 2000 [cited by applicant]
US 6143164A · Heller et al. · 2000 [cited by applicant]
US 6162611A · Heller et al. · 2000 [cited by applicant]
US 6175752B1 · Say et al. · 2001 [cited by applicant]
US 6183412B1 · Benkowski et al. · 2001 [cited by applicant]
US 6186982B1 · Gross et al. · 2001 [cited by applicant]
US 6246992B1 · Brown · 2001 [cited by applicant]
US 6248067B1 · Causey, III et al. · 2001 [cited by applicant]
US 6248093B1 · Moberg · 2001 [cited by applicant]
US 6254586B1 · Mann et al. · 2001 [cited by applicant]
US 6259937B1 · Schulman et al. · 2001 [cited by applicant]
US 6329161B1 · Heller et al. · 2001 [cited by applicant]
US 6355021B1 · Nielsen et al. · 2002 [cited by applicant]
US 6368141B1 · Vanantwerp et al. · 2002 [cited by applicant]
US 6379301B1 · Worthington et al. · 2002 [cited by applicant]
US 6408330B1 · DeLahuerga · 2002 [cited by applicant]
US 6418332B1 · Mastrototaro et al. · 2002 [cited by applicant]
US 6424847B1 · Mastrototaro et al. · 2002 [cited by applicant]
US 6461331B1 · Van Antwerp · 2002 [cited by applicant]
US 6472122B1 · Schulman et al. · 2002 [cited by applicant]
US 6484045B1 · Holker et al. · 2002 [cited by applicant]
US 6484046B1 · Say et al. · 2002 [cited by applicant]
US 6503381B1 · Gotoh et al. · 2003 [cited by applicant]
US 6514718B2 · Heller et al. · 2003 [cited by applicant]
US 6544173B2 · West et al. · 2003 [cited by applicant]
US 6544212B2 · Galley et al. · 2003 [cited by applicant]
US 6553263B1 · Meadows et al. · 2003 [cited by applicant]
US 6554798B1 · Mann et al. · 2003 [cited by applicant]
US 6558320B1 · Causey, III et al. · 2003 [cited by applicant]
US 6558351B1 · Steil et al. · 2003 [cited by applicant]
US 6560741B1 · Gerety et al. · 2003 [cited by applicant]
US 6565509B1 · Say et al. · 2003 [cited by applicant]
US 6579690B1 · Bonnecaze et al. · 2003 [cited by applicant]
US 6591125B1 · Buse et al. · 2003 [cited by applicant]
US 6591876B2 · Safabash · 2003 [cited by applicant]
US 6592745B1 · Feldman et al. · 2003 [cited by applicant]
US 6605200B1 · Mao et al. · 2003 [cited by applicant]
US 6605201B1 · Mao et al. · 2003 [cited by applicant]
US 6607658B1 · Heller et al. · 2003 [cited by applicant]
US 6616819B1 · Liamos et al. · 2003 [cited by applicant]
US 6618934B1 · Feldman et al. · 2003 [cited by applicant]
US 6623501B2 · Heller et al. · 2003 [cited by applicant]
US 6641533B2 · Causey, III et al. · 2003 [cited by applicant]
US 6654625B1 · Say et al. · 2003 [cited by applicant]
US 6659980B2 · Moberg et al. · 2003 [cited by applicant]
US 6671554B2 · Gibson et al. · 2003 [cited by applicant]
US 6676816B2 · Mao et al. · 2004 [cited by applicant]
US 6689265B2 · Heller et al. · 2004 [cited by applicant]
US 6728576B2 · Thompson et al. · 2004 [cited by applicant]
US 6733471B1 · Ericson et al. · 2004 [cited by applicant]
US 6734162B2 · Van Antwerp et al. · 2004 [cited by applicant]
US 6736797B1 · Larsen et al. · 2004 [cited by applicant]
US 6746582B2 · Heller et al. · 2004 [cited by applicant]
US 6747556B2 · Medema et al. · 2004 [cited by applicant]
US 6749587B2 · Flaherty · 2004 [cited by applicant]
US 6749740B2 · Liamos et al. · 2004 [cited by applicant]
US 6752787B1 · Causey, III et al. · 2004 [cited by applicant]
US 6766183B2 · Walsh et al. · 2004 [cited by applicant]
US 6801420B2 · Talbot et al. · 2004 [cited by applicant]
US 6804544B2 · Van et al. · 2004 [cited by applicant]
US 6809653B1 · Mann et al. · 2004 [cited by applicant]
US 6881551B2 · Heller et al. · 2005 [cited by applicant]
US 6892085B2 · McIvor et al. · 2005 [cited by applicant]
US 6893545B2 · Gotoh et al. · 2005 [cited by applicant]
US 6895263B2 · Shin et al. · 2005 [cited by applicant]
US 6916159B2 · Rush et al. · 2005 [cited by applicant]
US 6932584B2 · Gray et al. · 2005 [cited by applicant]
US 6932894B2 · Mao et al. · 2005 [cited by applicant]
US 6942518B2 · Liamos et al. · 2005 [cited by applicant]
US 7003336B2 · Holker et al. · 2006 [cited by applicant]
US 7066909B1 · Peter et al. · 2006 [cited by applicant]
US 7137964B2 · Flaherty · 2006 [cited by applicant]
US 7153263B2 · Carter et al. · 2006 [cited by applicant]
US 7153289B2 · Vasko · 2006 [cited by applicant]
US 7303549B2 · Flaherty et al. · 2007 [cited by applicant]
US 7396330B2 · Banet et al. · 2008 [cited by applicant]
US 7442186B2 · Blomquist · 2008 [cited by applicant]
US 7500949B2 · Gottlieb et al. · 2009 [cited by applicant]
US 7602310B2 · Mann et al. · 2009 [cited by applicant]
US 7647237B2 · Malave et al. · 2010 [cited by applicant]
US 7699807B2 · Faust et al. · 2010 [cited by applicant]
US 7727148B2 · Talbot et al. · 2010 [cited by applicant]
US 7785313B2 · Mastrototaro · 2010 [cited by applicant]
US 7806886B2 · Kanderian, Jr. et al. · 2010 [cited by applicant]
US 7819843B2 · Mann et al. · 2010 [cited by applicant]
US 7828764B2 · Moberg et al. · 2010 [cited by applicant]
US 7879010B2 · Hunn et al. · 2011 [cited by applicant]
US 7892206B2 · Moberg et al. · 2011 [cited by applicant]
US 7892748B2 · Norrild et al. · 2011 [cited by applicant]
US 7901394B2 · Ireland et al. · 2011 [cited by applicant]
US 7942844B2 · Moberg et al. · 2011 [cited by applicant]
US 7955305B2 · Moberg et al. · 2011 [cited by applicant]
US 7963954B2 · Kavazov · 2011 [cited by applicant]
US 7977112B2 · Burke et al. · 2011 [cited by applicant]
US 7979259B2 · Brown · 2011 [cited by applicant]
US 7985330B2 · Wang et al. · 2011 [cited by applicant]
US 8024201B2 · Brown · 2011 [cited by applicant]
US 8100852B2 · Moberg et al. · 2012 [cited by applicant]
US 8114268B2 · Wang et al. · 2012 [cited by applicant]
US 8114269B2 · Cooper et al. · 2012 [cited by applicant]
US 8137314B2 · Mounce et al. · 2012 [cited by applicant]
US 8181849B2 · Bazargan et al. · 2012 [cited by applicant]
US 8182462B2 · Istoc et al. · 2012 [cited by applicant]
US 8192395B2 · Estes et al. · 2012 [cited by applicant]
US 8195265B2 · Goode, Jr. et al. · 2012 [cited by applicant]
US 8202250B2 · Stutz, Jr. · 2012 [cited by applicant]
US 8207859B2 · Enegren et al. · 2012 [cited by applicant]
US 8226615B2 · Bikovsky · 2012 [cited by applicant]
US 8257259B2 · Brauker et al. · 2012 [cited by applicant]
US 8267921B2 · Yodfat et al. · 2012 [cited by applicant]
US 8277415B2 · Mounce et al. · 2012 [cited by applicant]
US 8292849B2 · Bobroff et al. · 2012 [cited by applicant]
US 8298172B2 · Nielsen et al. · 2012 [cited by applicant]
US 8303572B2 · Adair et al. · 2012 [cited by applicant]
US 8305580B2 · Aasmul · 2012 [cited by applicant]
US 8308679B2 · Hanson et al. · 2012 [cited by applicant]
US 8313433B2 · Cohen et al. · 2012 [cited by applicant]
US 8318443B2 · Norrild et al. · 2012 [cited by applicant]
US 8323250B2 · Chong et al. · 2012 [cited by applicant]
US 8343092B2 · Rush et al. · 2013 [cited by applicant]
US 8352011B2 · Van et al. · 2013 [cited by applicant]
US 8353829B2 · Say et al. · 2013 [cited by applicant]
US 8690820B2 · Cinar et al. · 2014 [cited by applicant]
US 8876755B2 · Taub et al. · 2014 [cited by applicant]
US 9526834B2 · Keenan et al. · 2016 [cited by applicant]
US 9878096B2 · Roy et al. · 2018 [cited by applicant]
US 9943644B2 · Hayter · 2018 [cited by applicant]
US 10130767B2 · Grosman et al. · 2018 [cited by applicant]
US 10758674B2 · Keenan et al. · 2020 [cited by applicant]
US 11241535B2 · Mastrototaro et al. · 2022 [cited by applicant]
US 11338086B2 · Roy · 2022 [cited by examiner]
US 11628250B2 · Grosman et al. · 2023 [cited by applicant]
US 11986633B2 · Grosman et al. · 2024 [cited by applicant]
US 20010044731A1 · Coffman et al. · 2001 [cited by applicant]
US 20020013518A1 · West et al. · 2002 [cited by applicant]
US 20020055857A1 · Mault · 2002 [cited by applicant]
US 20020082665A1 · Haller et al. · 2002 [cited by applicant]
US 20020137997A1 · Mastrototaro et al. · 2002 [cited by applicant]
US 20030060765A1 · Campbell et al. · 2003 [cited by applicant]
US 20030078560A1 · Miller et al. · 2003 [cited by applicant]
US 20030088166A1 · Say et al. · 2003 [cited by applicant]
US 20030144581A1 · Conn et al. · 2003 [cited by applicant]
US 20030152823A1 · Heller · 2003 [cited by applicant]
US 20030163223A1 · Blomquist · 2003 [cited by applicant]
US 20030176183A1 · Drucker et al. · 2003 [cited by applicant]
US 20030188427A1 · Say et al. · 2003 [cited by applicant]
US 20030199744A1 · Buse et al. · 2003 [cited by applicant]
US 20030208113A1 · Mault et al. · 2003 [cited by applicant]
US 20030220552A1 · Reghabi et al. · 2003 [cited by applicant]
US 20040061232A1 · Shah et al. · 2004 [cited by applicant]
US 20040061234A1 · Shah et al. · 2004 [cited by applicant]
US 20040064133A1 · Miller et al. · 2004 [cited by applicant]
US 20040064156A1 · Shah et al. · 2004 [cited by applicant]
US 20040073095A1 · Causey et al. · 2004 [cited by applicant]
US 20040074785A1 · Holker et al. · 2004 [cited by applicant]
US 20040093167A1 · Braig et al. · 2004 [cited by applicant]
US 20040097796A1 · Berman et al. · 2004 [cited by applicant]
US 20040102683A1 · Khanuja et al. · 2004 [cited by applicant]
US 20040111017A1 · Say et al. · 2004 [cited by applicant]
US 20040122353A1 · Shahmirian et al. · 2004 [cited by applicant]
US 20040167465A1 · Mihai et al. · 2004 [cited by applicant]
US 20040263354A1 · Mann et al. · 2004 [cited by applicant]
US 20050038331A1 · Silaski et al. · 2005 [cited by applicant]
US 20050038680A1 · McMahon · 2005 [cited by applicant]
US 20050154271A1 · Rasdal et al. · 2005 [cited by applicant]
US 20050192557A1 · Brauker et al. · 2005 [cited by applicant]
US 20060229694A1 · Schulman et al. · 2006 [cited by applicant]
US 20060238333A1 · Welch et al. · 2006 [cited by applicant]
US 20060293571A1 · Bao et al. · 2006 [cited by applicant]
US 20070088521A1 · Shmueli et al. · 2007 [cited by applicant]
US 20070106135A1 · Sloan et al. · 2007 [cited by applicant]
US 20070123819A1 · Mernoe et al. · 2007 [cited by applicant]
US 20070135866A1 · Baker et al. · 2007 [cited by applicant]
US 20070173761A1 · Kanderian et al. · 2007 [cited by applicant]
US 20070179671A1 · Arimatsu et al. · 2007 [cited by applicant]
US 20070276279A1 · Echauz et al. · 2007 [cited by applicant]
US 20080154503A1 · Wittenber et al. · 2008 [cited by applicant]
US 20080228056A1 · Blomquist et al. · 2008 [cited by applicant]
US 20080269723A1 · Mastrototaro et al. · 2008 [cited by applicant]
US 20080275384A1 · Mastrototaro · 2008 [cited by applicant]
US 20090081951A1 · Erdmann et al. · 2009 [cited by applicant]
US 20090082635A1 · Baldus et al. · 2009 [cited by applicant]
US 20100057040A1 · Hayter · 2010 [cited by applicant]
US 20100057041A1 · Hayter · 2010 [cited by applicant]
US 20100160861A1 · Causey, III et al. · 2010 [cited by applicant]
US 20100185175A1 · Kamen et al. · 2010 [cited by applicant]
US 20100262117A1 · Magni et al. · 2010 [cited by applicant]
US 20110028279A1 · Chen · 2011 [cited by applicant]
US 20110054391A1 · Ward et al. · 2011 [cited by applicant]
US 20110106011A1 · Cinar et al. · 2011 [cited by applicant]
US 20110313390A1 · Roy et al. · 2011 [cited by applicant]
US 20130245547A1 · El-Khatib et al. · 2013 [cited by applicant]
US 20140066892A1 · Keenan et al. · 2014 [cited by applicant]
US 20190076600A1 · Grosman et al. · 2019 [cited by applicant]
US 20200353168A1 · Keenan et al. · 2020 [cited by applicant]
US 20220118182A1 · Mastrototaro et al. · 2022 [cited by applicant]
CN 1859943A · 2006 [cited by applicant]
CN 1914715A · 2007 [cited by applicant]
CN 1973768A · 2007 [cited by applicant]
CN 101675438A · 2010 [cited by applicant]
CN 102056645A · 2011 [cited by applicant]
CN 102334113A · 2012 [cited by applicant]
CN 102369032A · 2012 [cited by applicant]
CN 102576375A · 2012 [cited by applicant]
CN 102946923A · 2013 [cited by applicant]
DE 4329229A1 · 1995 [cited by applicant]
EP 0319268A2 · 1989 [cited by applicant]
EP 0806738A1 · 1997 [cited by applicant]
EP 0880936A2 · 1998 [cited by applicant]
EP 1338295A1 · 2003 [cited by applicant]
EP 1631036A2 · 2006 [cited by applicant]
GB 2218831A · 1989 [cited by applicant]
JP 2006510467A · 2006 [cited by applicant]
JP 2007516814A · 2007 [cited by applicant]
JP 2010512945A · 2010 [cited by applicant]
JP 2010519623A · 2010 [cited by applicant]
JP 2010521222A · 2010 [cited by applicant]
JP 2012502693A · 2012 [cited by applicant]
WO 9620745A1 · 1996 [cited by applicant]
WO 9625088A1 · 1996 [cited by applicant]
WO 9636389A1 · 1996 [cited by applicant]
WO 9637246A1 · 1996 [cited by applicant]
WO 9721456A1 · 1997 [cited by applicant]
WO 9820439A1 · 1998 [cited by applicant]
WO 9824358A2 · 1998 [cited by applicant]
WO 9842407A1 · 1998 [cited by applicant]
WO 9849659A2 · 1998 [cited by applicant]
WO 9856293A1 · 1998 [cited by applicant]
WO 9859487A1 · 1998 [cited by applicant]
WO 9908183A1 · 1999 [cited by applicant]
WO 9910801A1 · 1999 [cited by applicant]
WO 9918532A1 · 1999 [cited by applicant]
WO 9922236A1 · 1999 [cited by applicant]
WO 9929230A1 · 1999 [cited by applicant]
WO 0010628A2 · 2000 [cited by applicant]
WO 0018449A2 · 2000 [cited by applicant]
WO 0019887A1 · 2000 [cited by applicant]
WO 0035530A1 · 2000 [cited by applicant]
WO 0048112A2 · 2000 [cited by applicant]
WO 0078210A1 · 2000 [cited by applicant]
WO 02058537A2 · 2002 [cited by applicant]
WO 02066101A2 · 2002 [cited by applicant]
WO 03001329A2 · 2003 [cited by applicant]
WO 03094090A2 · 2003 [cited by applicant]
WO 2005065538A2 · 2005 [cited by applicant]
WO 2011162970A1 · 2011 [cited by applicant]
WO 2014035570A2 · 2014 [cited by applicant]
WO 2014035672A2 · 2014 [cited by applicant]
Abel, P. et al., “Experience With an Implantable Glucose Sensor as a Prerequisite of an Artificial Beta Cell”, Biomed Biochim Acta, 1984, vol. 43, No. 5, pp. 577-584. [cited by applicant]
Bergman, R.N. et al., “Physiological Evaluation of Factors Controlling Glucose Tolerance in Man”, Journal of Clinical Investigation, The American Society for Clinical Investigation, Inc, Dec. 1981, vol. 68, pp. 1456-146… [cited by applicant]
Bindra, D.S. et al., “Design and in Vitro Studies of a Needle-type Glucose Sensor for Subcutaneous Monitoring”, American Chemistry Society, Sep. 1991, vol. 63, No. 17, pp. 1692-1696. [cited by applicant]
Bode, B.W. et al., “Reduction in Severe Hypoglycemia With Long-term Continuous Subcutaneous Insulin Infusion in Type I Diabetes”, Diabetes Care, Apr. 1996, vol. 19, No. 4, pp. 324-327. [cited by applicant]
Boguslavsky, L. et al., “Applications of Redox Polymers in Biosensors”, Solid State Ionics, Mar. 1993, vol. 60, No. 1-3, pp. 189-197. [cited by applicant]
Clarke et al., “Closed-Loop Artificial Pancreas Using Subcutaneous Glucose Sensing and Insulin Delivery and a Model-Predictive Control Algorithm: The Virginia Experience,” Journal of Diabetes Science and Technology, Sep… [cited by applicant]
D'Azzo, J. et al., “Linear Control System Analysis and Design with Matlab,” Marcel Dekker, Inc, 2003, 31 pages. [cited by applicant]
Disetronic H-TRON® plus Quick Start Manual, 91 pages, [pre-2012]. [cited by applicant]
Disetronic H-TRON® plus Reference Manual, 83 pages, [pre-2012]. [cited by applicant]