Apparatus for diagnosing lung cancer based on exhaled breath and method for diagnosing same
Provided are an apparatus for diagnosing a disease and a method for diagnosing same. The apparatus includes a pump for pumping respiratory gas, a first pre-treatment portion connected to the pump and removing moisture and bad breath in the respiratory gas, and a volatile organic compound detector connected between the first pre-treatment portion and the pump and detecting volatile organic compounds in the respiratory gas.
1. A disease diagnostic apparatus comprising:
a pump configured to pump respiratory gas;
a first pre-treatment portion connected to the pump and configured to remove moisture and bad breath in the respiratory gas;
a second pre-treatment portion disposed between the first pre-treatment portion and the pump and configured to regulate humidity of the respiratory gas;
a third pre-treatment portion disposed between the second pre-treatment portion and the pump and configured to regulate noise of non-polar volatile organic compounds in the respiratory gas;
a fourth pre-treatment portion which is connected between the third pre-treatment portion and the volatile organic compound detector and regulates noise of polar volatile organic compounds in the respiratory gas; and
a volatile organic compound detector connected between the third pre-treatment portion and the pump and configured to detect volatile organic compounds in the respiratory gas.
2. The disease diagnostic apparatus of claim 1 , wherein the fourth pre-treatment portion comprises:
a phenol bubbler configured to evaporate a phenol solution; and
a phenol gas sensor disposed between the phenol bubbler and the volatile organic compound detector and configured to detect a phenol gas in the volatile organic compounds.
3. The disease diagnostic apparatus of claim 2 , wherein the phenol bubbler comprises:
a phenol bath configured to store the phenol solution; and
a carrier gas supplier which is connected to the phenol bath and provides a carrier gas into the phenol solution to generate the phenol gas.
4. The disease diagnostic apparatus of claim 1 , wherein the first pre-treatment portion comprises:
a first chamber;
a moisture filter disposed inside the first chamber and configured to remove the moisture; and
a bad breath filter disposed between the moisture filter and the volatile organic compound detector and configured to remove the bad breath.
5. The disease diagnostic apparatus of claim 4 , wherein the first pre-treatment portion further comprises a first heater which is disposed in the first chamber and surrounds the moisture filter and the bad breath filter.
6. The disease diagnostic apparatus of claim 1 , wherein the second pre-treatment portion comprises:
a water bubbler configured to evaporate DI water; and
a hygrometer provided between the water bubbler and the volatile organic compound detector and configured to detect humidity of the respiratory gas.
7. The disease diagnostic apparatus of claim 6 , wherein the water bubbler comprises:
a water bath configured to store the DI water; and
a carrier gas supplier which is connected to the water bath and provides a carrier gas into the DI water to generate water vapor of the DI water.
8. The disease diagnostic apparatus of claim 6 , wherein the third pre-treatment portion comprises:
a benzene bubbler configured to evaporate a benzene solution; and
a non-polar volatile organic compound gas sensor disposed between the benzene bubbler and the volatile organic compound detector and configured to detect a benzene gas in the volatile organic compounds.
9. The disease diagnostic apparatus of claim 8 , wherein the benzene bubbler comprises:
a benzene bath configured to store the benzene solution; and
a carrier gas supplier which is connected to the benzene bath and provides a carrier gas into the benzene solution to generate the benzene gas.
10. A disease diagnostic apparatus comprising:
a first intake line;
a volatile organic compound detector configured to detect volatile organic compounds in respiratory gas;
a first pre-treatment portion connected between the volatile organic compound detector and the first intake line and configured to remove moisture and bad breath in the respiratory gas;
a second pre-treatment portion connected between the first pre-treatment portion and the volatile organic compound detector and configured to regulate humidity of the respiratory gas;
a third pre-treatment portion connected between the second pre-treatment portion and the volatile organic compound detector and configured to regulate noise of non-polar volatile organic compounds in the respiratory gas; and
a fourth pre-treatment portion connected between the third pre-treatment portion and the volatile organic compound detector and configured to regulate noise of polar volatile organic compounds in the respiratory gas.
11. The disease diagnostic apparatus of claim 10 , comprising:
a second intake line configured to connect the fourth pre-treatment portion to the volatile organic compound detector;
a third intake line configured to connect the first pre-treatment portion to the second pre-treatment portion;
a fourth intake line configured to connect the second pre-treatment portion to the third pre-treatment portion;
a fifth intake line configured to connect the third pre-treatment portion to the fourth pre-treatment portion; and
a first bypass line which is branched from the first intake line and connected to the second intake line, thereby bypassing the first pre-treatment portion.
12. The disease diagnostic apparatus of claim 11 , further comprising a second bypass line which is branched from the first bypass line and the second pre-treatment portion.
13. The disease diagnostic apparatus of claim 12 , further comprising a third bypass line which is branched from the second bypass line and the third pre-treatment portion.
14. The disease diagnostic apparatus of claim 13 , further comprising a fourth bypass line which bypasses the fourth pre-treatment portion.
15. A disease diagnostic method comprising:
pumping respiratory gas;
removing moisture in the respiratory gas by using a moisture filter;
removing bad breath in the respiratory gas by using a bad breath filter;
regulating humidity of the respiratory gas to reference humidity by evaporating DI water;
regulating concentration of benzene gas in the respiratory gas to first reference concentration by evaporating a benzene solution;
detecting volatile organic compounds in the respiratory gas by using a sensor array, thereby determining whether a lung cancer is in the human body; and
regulating concentration of phenol gas in the respiratory gas to second reference concentration by evaporating a phenol solution.
16. The disease diagnostic method of claim 15 , wherein the reference humidity is 40% to 60%.
17. The disease diagnostic method of claim 15 , wherein the first reference concentration is 0.1 ppm to 0.5 ppm.