IP Library › Granted Patent US 12,303,119
Granted Patent B2
US 12,303,119 · App. 18/174,372 · Granted May 20, 2025

Apparatus and methods to create and maintain an intra-atrial pressure relief opening

Inventors: David S. Celermajer (Vaucluse, AU); Edward I. McNamara (Chelmsford, MA); Michael W. Sutherland (Groton, MA); Hiroatsu Sugimoto (Cambridge, MA)
Assignee: CORVIA MEDICAL, INC.
A61B17/0057A61B17/02A61B17/32A61B17/320016A61B17/32053A61B17/3478A61B18/1492A61F2/06A61F2/2412A61F2/2442A61F2/2475A61M25/0068A61M25/0662A61M25/1002A61M27/002A61M29/02A61B6/12A61B6/503A61B8/0841A61B8/0883A61B2017/00247A61B2017/00252A61B2017/00575A61B2017/00592A61B2017/00606A61B2017/00867A61B2017/0237A61B2017/22044A61B2017/320004A61B2017/320008A61B17/32002A61B2017/320064A61B2017/3488A61B2018/0022A61B2018/00351A61B2018/00577A61B2018/046A61B2018/1467A61B18/24A61M2025/0039A61M2025/0681A61M2025/09008A61M2025/105A61M2025/1086A61M2025/1088A61N7/022
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Quick Facts
Patent No.
US 12,303,119
App. No.
18/174,372
Granted
May 20, 2025
Kind
B2
Abstract

The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal. The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

Claims (24)

1. A system for normalizing elevated blood pressure in a heart chamber, the system comprising:

a penetrator with a sharpened tip for penetrating an atrial septum between a left atrium and a right atrium by creating an opening having a first diameter;

a dilation catheter configured to advance through the opening, wherein the dilation catheter has a conical distal tip and an elongated substantially tubular shaft proximal to the conical distal tip, and is configured to be advanced over the penetrator;

a treatment mechanism for transferring heat energy to tissue around the opening in order to ablate or otherwise damage tissue around the opening in order to slow or prevent natural healing of a second diameter opening, larger than the first diameter, in the atrial septum without implanting a stent or valve in the atrial septum; and

a tissue grasper comprising a plurality of retaining prongs, the plurality of retaining prongs extending proximally and radially outwardly from the tissue grasper, the plurality retaining prongs configured to engage tissue.

2. The system according to claim 1 , wherein the treatment mechanism is in a form of a thin wire electrode spiraling around the elongated substantially tubular shaft of the dilation catheter proximal to the conical distal tip.

3. The system according to claim 1 , wherein the treatment mechanism is in a form of radio frequency (RF) electrodes exposed on the surface of the elongated substantially tubular shaft of the dilation catheter proximal to the conical distal tip.

4. The system according to claim 3 , wherein the radio frequency (RF) electrodes have two semi-circular shapes.

5. The system according to claim 1 , wherein the treatment mechanism is in a form of multiple arrays of piezoelectric ultrasound transducers spaced around a circumference of the elongated substantially tubular shaft of the dilation catheter proximal to the conical distal tip.

6. The system according to claim 1 , wherein the treatment mechanism is in a form of a textured or ribbed cylindrical section coupled to the elongated substantially tubular shaft of the dilation catheter proximal to the conical distal tip.

7. The system according to claim 1 , wherein the treatment mechanism is adapted to deliver heat energy to ablate or otherwise damage the tissue surrounding the opening, in order to slow a natural healing process of the tissue.

8. The system according to claim 1 , wherein the treatment mechanism is adapted to abrade or scrape the tissue surrounding the opening in order to encourage a formation of thickened scar tissue.

9. A method for normalizing elevated blood pressure in a heart chamber, the method comprising:

penetrating an atrial septum between a right atrium and a left atrium of a heart to create an opening in the atrial septum;

inserting a dilator comprising a conical tip and an elongate body proximal to the conical tip through the opening;

separating tissue around the opening to form an intra-atrial pressure relief opening;

applying energy to the tissue to slow a natural healing process of the tissue to maintain patency of the intra-atrial pressure relief opening without implanting a stent or valve in the intra-atrial pressure relief opening;

engaging one or more prongs of a grasper comprising a plurality of retaining prongs extending proximally and radially outwardly from the grasper;

retracting the grasper into a sheath; and

permitting blood to flow from the left atrium to the right atrium through the intra-atrial pressure relief opening to reduce left atrial pressure.

10. The method of claim 9 , wherein applying energy to the tissue comprises ablating, heating or cooling the tissue near the intra-atrial pressure relief opening.

11. The method of claim 9 , wherein applying energy to the tissue comprises providing radiation energy to the tissue near the intra-atrial pressure relief opening.

12. The method of claim 9 , wherein separating tissue around the opening comprises providing radiation energy to the tissue around the opening.

13. The method of claim 9 wherein separating tissue around the opening comprises ablating the tissue around the opening.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2023
From: CELERMAJER, DAVID S.; MCNAMARA, EDWARD I.; SUTHERLAND, MICHAEL W.; SUGIMOTO, HIROATSU
To: CORVIA MEDICAL, INC.
Reel/Frame 065248/0713 →
Continuity (5)
Continuation 16417576 · May 20, 2019
Continuation 13905638 · May 30, 2013
Division 13370913 · Feb 10, 2012
Provisional Application 61441546 · Feb 10, 2011
Related Publication 20240023948A1 · Jan 25, 2024
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