IP Library › Granted Patent US 12,329,388
Granted Patent B2
US 12,329,388 · App. 18/378,628 · Granted Jun 17, 2025

Medical device and system for occluding a tissue opening and method thereof

Inventors: Sung K. Lee (West Jordan, UT); Marie A. K. Biscarrat (Salt Lake City, UT); Juan M. R. Soto (West Jordan, UT); Tom Ditter (Mission Viejo, CA)
A61B17/12122A61B17/1214A61B2017/00831
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Quick Facts
Patent No.
US 12,329,388
App. No.
18/378,628
Granted
Jun 17, 2025
Kind
B2
Abstract

Medical devices, systems and methods for occluding a left atrial appendage of a heart are provided. In one embodiment, the medical device includes an occluder portion and an anchor portion that are pivotably coupled to each other with hinge components. The hinge components each include a base with arms extending from the base such that the arms of each one of the hinge components extend through and capture a first eyelet of the occluder portion and a second eyelet of the anchor portion to facilitate pivotably coupling the anchor portion to the occluder portion.

Claims (16)

1. A method of occluding a left atrial appendage of a heart, the method comprising:

advancing a medical device with a catheter through a vasculature and to the left atrial appendage, the medical device having a framework extending between a primary hub and a secondary hub, the primary hub and the secondary hub having a common axis, the framework extending with hinge components between an occluder portion and an anchor portion of the framework such that each of the hinge components includes a base and arms extending from the base;

deploying the framework adjacent the left atrial appendage from a constricted position to a deployed position such that the secondary hub is moveable along the axis relative to the primary hub and such that the anchor portion pivots about the hinge components with the arms of each of the hinge components positioned through corresponding ones of an anchor eyelet defined in the anchor portion and the arms of each of the hinge components positioned through corresponding ones of an occluder eyelet defined in the occluder portion, each of the hinge components including a key structure, the key structure sized and configured to correspond and engage with recesses defined in corresponding ones of the occluder eyelet to prevent pivotable movement of the occluder portion relative to a corresponding one of the hinge components; and

releasing the medical device from the catheter with the framework of the medical device secured to tissue adjacent the left atrial appendage.

2. The method according to claim 1 , wherein, subsequent to the deploying the framework, pivoting the anchor portion by moving the secondary hub proximally to move the anchor portion to a retracted position such that tines of the anchor portion are retracted from the tissue.

3. The method according to claim 1 , wherein the deploying comprises securing the framework to the tissue adjacent the left atrial appendage with tines extending from the anchor portion of the framework.

4. The method according to claim 1 , further comprising maintaining the anchor portion coupled to the occluder portion of the framework with a catch surface of each of the arms of the hinge components such that the anchor and occluder eyelets define structure positioned between the catch surface and the base of each of the hinge components.

5. The method according to claim 1 , further comprising viewing markers integrated with the framework with imaging techniques to determine a landing zone of the framework, at least partially defined by the markers, relative to the tissue adjacent the left atrial appendage.

6. A method of occluding a left atrial appendage of a heart, the method comprising:

advancing a medical device with a catheter through a vasculature and to the left atrial appendage, the medical device having a framework extending between a primary hub and a secondary hub, the primary hub and the secondary hub having a common axis, the framework extending with hinge components between a first eyelet of a first frame portion and a second eyelet of a second frame portion of the framework such that each of the hinge components includes a base and arms extending from the base;

deploying the framework adjacent the left atrial appendage from a constricted position to a deployed position such that the secondary hub is moveable along the axis relative to the primary hub and such that the second frame portion pivots about the hinge components with the arms of each of the hinge components positioned through corresponding ones of the second eyelet defined in the second frame portion and the arms of each of the hinge components positioned through corresponding ones of the first eyelet defined in the first frame portion, each of the hinge components including a key structure, the key structure sized and configured to correspond and engage with recesses defined in corresponding ones of the first eyelet to prevent pivotable movement of the first frame portion relative to a corresponding one of the hinge components; and

releasing the medical device from the catheter with the framework of the medical device secured to tissue adjacent the left atrial appendage.

7. The method according to claim 6 , wherein, subsequent to the deploying the framework, pivoting the second frame portion by moving the secondary hub proximally to move the second frame portion to a retracted position such that tines of the second frame portion are retracted from the tissue.

8. The method according to claim 6 , wherein the deploying comprises securing the framework to the tissue adjacent the left atrial appendage with tines extending from the second frame portion of the framework.

9. The method according to claim 6 , further comprising maintaining the second frame portion coupled to the first frame portion of the framework with a catch surface of each of the arms of the hinge components such that the first and second eyelets define structure positioned between the catch surface and the base of each of the hinge components.

10. The method according to claim 6 , further comprising viewing markers integrated with the framework with imaging techniques to determine a landing zone of the framework, at least partially defined by the markers, relative to the tissue adjacent the left atrial appendage.

Assignments (1)
NUNC PRO TUNC ASSIGNMENT Recorded Jan 11, 2024
From: LEE, SUNG K.; BISCARRAT, MARIE A. K.; SOTO, JUAN M. R.; DITTER, TOM
To: COHEREX MEDICAL, INC.
Reel/Frame 066098/0800 →
Continuity (2)
Division 17111415 · Dec 3, 2020
Related Publication 20240032936A1 · Feb 1, 2024
References Cited (275)
US 3095877A · Rowan · 1963 [cited by applicant]
US 3803670A · Johnson · 1974 [cited by applicant]
US 3874388A · King et al. · 1975 [cited by applicant]
US 5171259A · Inoue · 1992 [cited by applicant]
US 5192301A · Kamiya et al. · 1993 [cited by applicant]
US 5284488A · Sideris · 1994 [cited by applicant]
US 5334217A · Das · 1994 [cited by applicant]
US 5425733A · Schmieding · 1995 [cited by applicant]
US 5425740A · Hutchinson, Jr. · 1995 [cited by applicant]
US 5433727A · Sideris · 1995 [cited by applicant]
US 5792165A · Klieman et al. · 1998 [cited by applicant]
US 5797886A · Roth et al. · 1998 [cited by applicant]
US 5861003A · Latson et al. · 1999 [cited by applicant]
US 5904703A · Gilson · 1999 [cited by applicant]
US 5910154A · Tsugita et al. · 1999 [cited by applicant]
US 5935112A · Stevens et al. · 1999 [cited by applicant]
US 5992158A · Goddard et al. · 1999 [cited by applicant]
US 6096027A · Layne · 2000 [cited by applicant]
US 6152144A · Lesh et al. · 2000 [cited by applicant]
US 6174322B1 · Schneidt · 2001 [cited by applicant]
US 6231561B1 · Frazier et al. · 2001 [cited by applicant]
US 6238403B1 · Greene et al. · 2001 [cited by applicant]
US 6290674B1 · Roue et al. · 2001 [cited by applicant]
US 6328727B1 · Frazier et al. · 2001 [cited by applicant]
US 6355051B1 · Sisskind et al. · 2002 [cited by applicant]
US 6371971B1 · Tsugita et al. · 2002 [cited by applicant]
US 6398760B1 · Danby · 2002 [cited by applicant]
US 6419669B1 · Frazier et al. · 2002 [cited by applicant]
US 6436088B2 · Frazier et al. · 2002 [cited by applicant]
US 6458100B2 · Roue et al. · 2002 [cited by applicant]
US 6488689B1 · Kaplan et al. · 2002 [cited by applicant]
US 6530934B1 · Jacobsen et al. · 2003 [cited by applicant]
US 6551303B1 · Van Tassel et al. · 2003 [cited by applicant]
US 6551341B2 · Boylan et al. · 2003 [cited by applicant]
US 6561969B2 · Frazier et al. · 2003 [cited by applicant]
US 6585754B2 · Wallace et al. · 2003 [cited by applicant]
US 6650923B1 · Lesh et al. · 2003 [cited by applicant]
US 6651557B1 · Frazier et al. · 2003 [cited by applicant]
US 6652555B1 · Van Tassel et al. · 2003 [cited by applicant]
US 6652556B1 · Van Tassel et al. · 2003 [cited by applicant]
US 6666861B1 · Grabek · 2003 [cited by applicant]
US 6689150B1 · Van Tassel et al. · 2004 [cited by applicant]
US 6702825B2 · Frazier et al. · 2004 [cited by applicant]
US 6706065B2 · Langberg et al. · 2004 [cited by applicant]
US 6712804B2 · Roue et al. · 2004 [cited by applicant]
US 6730108B2 · Van Tassel et al. · 2004 [cited by applicant]
US 6746472B2 · Frazier et al. · 2004 [cited by applicant]
US 6790229B1 · Berreklouw · 2004 [cited by applicant]
US 6843802B1 · Villalobos et al. · 2005 [cited by applicant]
US 6949113B2 · Van Tassel et al. · 2005 [cited by applicant]
US 6979344B2 · Jones et al. · 2005 [cited by applicant]
US 6994092B2 · van der Burg et al. · 2006 [cited by applicant]
US 7011671B2 · Welch · 2006 [cited by applicant]
US 7014645B2 · Greene, Jr. et al. · 2006 [cited by applicant]
US 7025756B2 · Frazier et al. · 2006 [cited by applicant]
US 7044134B2 · Khairkhahan et al. · 2006 [cited by applicant]
US 7056294B2 · Khairkhahan et al. · 2006 [cited by applicant]
US 7115110B2 · Frazier et al. · 2006 [cited by applicant]
US 7128073B1 · van der Burg et al. · 2006 [cited by applicant]
US 7152605B2 · Khairkhahan et al. · 2006 [cited by applicant]
US 7169164B2 · Borillo et al. · 2007 [cited by applicant]
US 7192439B2 · Khairkhahan et al. · 2007 [cited by applicant]
US 7226458B2 · Kaplan et al. · 2007 [cited by applicant]
US 7293562B2 · Malecki et al. · 2007 [cited by applicant]
US 7597704B2 · Frazier et al. · 2009 [cited by applicant]
US 7608091B2 · Goldfarb et al. · 2009 [cited by applicant]
US 7717937B2 · Wahr et al. · 2010 [cited by applicant]
US 7727189B2 · Van Tassel et al. · 2010 [cited by applicant]
US 7780645B2 · Jones · 2010 [cited by applicant]
US 7842054B2 · Greene, Jr. et al. · 2010 [cited by applicant]
US 8142470B2 · Quinn et al. · 2012 [cited by applicant]
US 8597225B2 · Kapadia · 2013 [cited by applicant]
US 8636764B2 · Miles et al. · 2014 [cited by applicant]
US 8690911B2 · Miles et al. · 2014 [cited by applicant]
US 8715318B2 · Miles et al. · 2014 [cited by applicant]
US 8740934B2 · McGuckin, Jr. · 2014 [cited by applicant]
US 8795328B2 · Miles et al. · 2014 [cited by applicant]
US 8840641B2 · Miles et al. · 2014 [cited by applicant]
US 8845711B2 · Miles et al. · 2014 [cited by applicant]
US 9089422B2 · Ryan et al. · 2015 [cited by applicant]
US 9301838B2 · Kapadia · 2016 [cited by applicant]
US 9351716B2 · Miles et al. · 2016 [cited by applicant]
US 9649115B2 · Edmiston et al. · 2017 [cited by applicant]
US 9693780B2 · Miles et al. · 2017 [cited by applicant]
US 9693781B2 · Miles et al. · 2017 [cited by applicant]
US 9883864B2 · Miles et al. · 2018 [cited by applicant]
US 10314702B2 · Dehdashtian et al. · 2019 [cited by applicant]
US 10398441B2 · Warner et al. · 2019 [cited by applicant]
US 20010003161A1 · Vardi et al. · 2001 [cited by applicant]
US 20010037129A1 · Thill · 2001 [cited by applicant]
US 20010037141A1 · Yee et al. · 2001 [cited by applicant]
US 20020022860A1 · Borillo et al. · 2002 [cited by applicant]
US 20020026094A1 · Roth · 2002 [cited by applicant]
US 20020026217A1 · Baker et al. · 2002 [cited by applicant]
US 20020035374A1 · Borillo et al. · 2002 [cited by applicant]
US 20020062130A1 · Jugenheimer et al. · 2002 [cited by applicant]
US 20020111647A1 · Khairkhahan et al. · 2002 [cited by applicant]
US 20020177855A1 · Greene, Jr. et al. · 2002 [cited by applicant]
US 20020183787A1 · Wahr et al. · 2002 [cited by applicant]
US 20020183826A1 · Dorn et al. · 2002 [cited by applicant]
US 20030014075A1 · Rosehbluth et al. · 2003 [cited by applicant]
US 20030023266A1 · Borillo et al. · 2003 [cited by applicant]
US 20030050658A1 · Trask et al. · 2003 [cited by applicant]
US 20030055455A1 · Yang et al. · 2003 [cited by applicant]
US 20030057156A1 · Peterson et al. · 2003 [cited by applicant]
US 20030120337A1 · Van Tassel et al. · 2003 [cited by applicant]
US 20030125790A1 · Fastovsky et al. · 2003 [cited by applicant]
US 20030153935A1 · Mialhe · 2003 [cited by applicant]
US 20030171739A1 · Murphy et al. · 2003 [cited by applicant]
US 20030181942A1 · Sutton et al. · 2003 [cited by applicant]
US 20030187474A1 · Keegan et al. · 2003 [cited by applicant]
US 20030191526A1 · Van Tassel et al. · 2003 [cited by applicant]
US 20030195555A1 · Khairkhahan et al. · 2003 [cited by applicant]
US 20030199923A1 · Khairkhahan et al. · 2003 [cited by applicant]
US 20030204203A1 · Khairkhahan et al. · 2003 [cited by applicant]
US 20030208227A1 · Thomas · 2003 [cited by applicant]
US 20030212432A1 · Khairkhahan et al. · 2003 [cited by applicant]
US 20030220667A1 · Van Der Burg et al. · 2003 [cited by applicant]
US 20040034366A1 · Van Der Burg et al. · 2004 [cited by applicant]
US 20040049224A1 · Buehlmann et al. · 2004 [cited by applicant]
US 20040098028A1 · Martinez · 2004 [cited by applicant]
US 20040098031A1 · van der Burg et al. · 2004 [cited by applicant]
US 20040122467A1 · Van Tassel et al. · 2004 [cited by applicant]
US 20040127935A1 · Van Tassel et al. · 2004 [cited by applicant]
US 20040153120A1 · Seifert et al. · 2004 [cited by applicant]
US 20040181237A1 · Forde et al. · 2004 [cited by applicant]
US 20040215230A1 · Frazier et al. · 2004 [cited by applicant]
US 20040254594A1 · Alfaro · 2004 [cited by applicant]
US 20040260317A1 · Bloom et al. · 2004 [cited by applicant]
US 20040267191A1 · Gifford, III et al. · 2004 [cited by applicant]
US 20050004652A1 · Van Der Burg et al. · 2005 [cited by applicant]
US 20050033409A1 · Burke et al. · 2005 [cited by applicant]
US 20050038470A1 · Van Der Burg et al. · 2005 [cited by applicant]
US 20050043759A1 · Chanduszko · 2005 [cited by applicant]
US 20050049573A1 · Van Tassel et al. · 2005 [cited by applicant]
US 20050049681A1 · Greenhalgh et al. · 2005 [cited by applicant]
US 20050060017A1 · Fishell et al. · 2005 [cited by applicant]
US 20050065589A1 · Schneider et al. · 2005 [cited by applicant]
US 20050075665A1 · Brenzel et al. · 2005 [cited by applicant]
US 20050085843A1 · Opolski et al. · 2005 [cited by applicant]
US 20050090860A1 · Paprocki · 2005 [cited by applicant]
US 20050113861A1 · Corcoran et al. · 2005 [cited by applicant]
US 20050149173A1 · Hunter et al. · 2005 [cited by applicant]
US 20050177182A1 · van der Burg et al. · 2005 [cited by applicant]
US 20050192616A1 · Callister et al. · 2005 [cited by applicant]
US 20050192627A1 · Whisenant et al. · 2005 [cited by applicant]
US 20050222533A1 · Chanduszko et al. · 2005 [cited by applicant]
US 20050234540A1 · Peavey et al. · 2005 [cited by applicant]
US 20050234543A1 · Glaser et al. · 2005 [cited by applicant]
US 20050251144A1 · Wilson et al. · 2005 [cited by applicant]
US 20050256532A1 · Nayak et al. · 2005 [cited by applicant]
US 20050267524A1 · Chanduszko · 2005 [cited by applicant]
US 20050288706A1 · Widomski et al. · 2005 [cited by applicant]
US 20060000443A1 · Kado et al. · 2006 [cited by applicant]
US 20060004433A1 · Greenberg et al. · 2006 [cited by applicant]
US 20060009798A1 · Callister · 2006 [cited by applicant]
US 20060009800A1 · Christianson et al. · 2006 [cited by applicant]
US 20060020327A1 · Lashinski et al. · 2006 [cited by applicant]
US 20060036282A1 · Wahr et al. · 2006 [cited by applicant]
US 20060052816A1 · Bates et al. · 2006 [cited by applicant]
US 20060122646A1 · Corcoran et al. · 2006 [cited by applicant]
US 20060149299A1 · Greene et al. · 2006 [cited by applicant]
US 20060149307A1 · Durgin · 2006 [cited by applicant]
US 20060149314A1 · Borillo et al. · 2006 [cited by applicant]
US 20060155323A1 · Porter et al. · 2006 [cited by applicant]
US 20060206148A1 · Khairkhahan et al. · 2006 [cited by applicant]
US 20060210816A1 · Finley · 2006 [cited by applicant]
US 20060217761A1 · Opolski · 2006 [cited by applicant]
US 20060229668A1 · Prestezog et al. · 2006 [cited by applicant]
US 20060276839A1 · McGuckin, Jr. · 2006 [cited by applicant]
US 20070027456A1 · Gartner et al. · 2007 [cited by applicant]
US 20070066993A1 · Kreidler · 2007 [cited by applicant]
US 20070073247A1 · Ewaschuk · 2007 [cited by applicant]
US 20070083230A1 · Javois · 2007 [cited by applicant]
US 20070083232A1 · Lee · 2007 [cited by applicant]
US 20070088388A1 · Opolski et al. · 2007 [cited by applicant]
US 20070112382A1 · Thill et al. · 2007 [cited by applicant]
US 20070123934A1 · Whisenant et al. · 2007 [cited by applicant]
US 20070129753A1 · Quinn et al. · 2007 [cited by applicant]
US 20070129757A1 · Armstrong · 2007 [cited by applicant]
US 20070135826A1 · Zaver et al. · 2007 [cited by applicant]
US 20070149995A1 · Quinn et al. · 2007 [cited by applicant]
US 20070167981A1 · Opolski et al. · 2007 [cited by applicant]
US 20070173885A1 · Cartier et al. · 2007 [cited by applicant]
US 20070179527A1 · Eskuri et al. · 2007 [cited by applicant]
US 20070179583A1 · Goetzinger et al. · 2007 [cited by applicant]
US 20070191884A1 · Eskridge et al. · 2007 [cited by applicant]
US 20070198059A1 · Patel et al. · 2007 [cited by applicant]
US 20070213766A1 · Ravikumar · 2007 [cited by applicant]
US 20070237720A1 · Padilla et al. · 2007 [cited by applicant]
US 20070270891A1 · McGuckin · 2007 [cited by applicant]
US 20070276415A1 · Kladakis et al. · 2007 [cited by applicant]
US 20080039743A1 · Fox et al. · 2008 [cited by applicant]
US 20080039929A1 · Davis et al. · 2008 [cited by applicant]
US 20080119891A1 · Miles et al. · 2008 [cited by applicant]
US 20080215086A1 · Olsen et al. · 2008 [cited by applicant]
US 20080249562A1 · Cahill · 2008 [cited by applicant]
US 20080288042A1 · Purdy et al. · 2008 [cited by applicant]
US 20090025820A1 · Adams · 2009 [cited by applicant]
US 20090069840A1 · Hallisey · 2009 [cited by applicant]
US 20090099596A1 · McGuckin, Jr. et al. · 2009 [cited by applicant]
US 20090105747A1 · Chanduszko et al. · 2009 [cited by applicant]
US 20090112050A1 · Farnan et al. · 2009 [cited by applicant]
US 20090112249A1 · Miles et al. · 2009 [cited by applicant]
US 20090171386A1 · Amplatz et al. · 2009 [cited by applicant]
US 20090177163A1 · King et al. · 2009 [cited by applicant]
US 20090182405A1 · Arnault De La Menardiere et al. · 2009 [cited by applicant]
US 20090192518A1 · Golden et al. · 2009 [cited by applicant]
US 20090228038A1 · Amin · 2009 [cited by applicant]
US 20090299338A1 · di Palma · 2009 [cited by applicant]
US 20090318948A1 · Linder et al. · 2009 [cited by applicant]
US 20100191279A1 · Kassab et al. · 2010 [cited by applicant]
US 20100228279A1 · Miles et al. · 2010 [cited by applicant]
US 20100228285A1 · Miles et al. · 2010 [cited by applicant]
US 20100234878A1 · Hruska et al. · 2010 [cited by applicant]
US 20100324572A1 · Needleman · 2010 [cited by examiner]
US 20100324585A1 · Miles et al. · 2010 [cited by applicant]
US 20100324586A1 · Miles et al. · 2010 [cited by applicant]
US 20100324587A1 · Miles et al. · 2010 [cited by applicant]
US 20100324588A1 · Miles et al. · 2010 [cited by applicant]
US 20110022079A1 · Miles et al. · 2011 [cited by applicant]
US 20110046658A1 · Connor et al. · 2011 [cited by applicant]
US 20110054515A1 · Bridgeman et al. · 2011 [cited by applicant]
US 20110208233A1 · McGuckin, Jr. et al. · 2011 [cited by applicant]
US 20120316584A1 · Miles et al. · 2012 [cited by applicant]
US 20130138138A1 · Clark et al. · 2013 [cited by applicant]
US 20140135817A1 · Tischler et al. · 2014 [cited by applicant]
US 20140142617A1 · Arsen et al. · 2014 [cited by applicant]
US 20160278784A1 · Edmiston et al. · 2016 [cited by applicant]
US 20170156840A1 · Edmiston · 2017 [cited by examiner]
CA 2627408 · 2008 [cited by applicant]
CN 100594014C · 2010 [cited by applicant]
DE 102006056283 · 2008 [cited by applicant]
EP 1266630 · 2002 [cited by applicant]
EP 1358850 · 2003 [cited by applicant]
EP 1523957 · 2005 [cited by applicant]
EP 1741393 · 2007 [cited by applicant]
EP 1768604 · 2007 [cited by applicant]
EP 1659988 · 2010 [cited by applicant]
JP 2008536620 · 2008 [cited by applicant]
JP 2010500917 · 2010 [cited by applicant]
WO 199933402 · 1999 [cited by applicant]
WO 0027292 · 2000 [cited by applicant]
WO WO0130266 · 2001 [cited by applicant]
WO 200193920 · 2001 [cited by applicant]
WO 2002071977 · 2002 [cited by applicant]
WO 2003028802 · 2003 [cited by applicant]
WO 2004045393 · 2004 [cited by applicant]
WO 2004100803 · 2004 [cited by applicant]
WO 2005053547 · 2005 [cited by applicant]
WO 2005099365 · 2005 [cited by applicant]
WO 2006033641 · 2006 [cited by applicant]
WO 2006047748 · 2006 [cited by applicant]
WO 2007054116 · 2007 [cited by applicant]
WO 2007147145 · 2007 [cited by applicant]
WO WO2008150346 · 2008 [cited by applicant]
WO 2010081033 · 2010 [cited by applicant]
WO 2010148246 · 2010 [cited by applicant]
WO WO2014078078 · 2014 [cited by applicant]
WO WO2019064308 · 2019 [cited by applicant]
Partial International Search Report dated Feb. 14, 2022 for International App. No. PCT/IB2021/060666 (15 pages). [cited by applicant]
European Search Report dated Aug. 6, 2018 for EP App. No. 18157669.5 (15 pages). [cited by applicant]
Supplemental European Search Report dated Jan. 3, 2019 for EP App. No. 18185291.4 (6 pages). [cited by applicant]
English Abstract and English machine translation of the Specification and Claims of DE 102006056283. Jun. 5, 2008. [cited by applicant]
Office Action and English Translation issued in JP2012-516313 on Mar. 25, 2014. [cited by applicant]
International Search Report dated Feb. 7, 2013 for International Application No. PCT/US2012/063074 (5 pages). [cited by applicant]
International Search Report dated Apr. 26, 2010 for International Application No. PCT/US2010/020549 (7 pages). [cited by applicant]
International Search Report dated May 7, 2010 for International Application No. PCT/US2010/020547 (4 pages). [cited by applicant]
International Search Report dated May 6, 2010 for International Application No. PCT/US2010/020539 (5 pages). [cited by applicant]
International Search Report dated Jun. 15, 2009 for International Application No. PCT/US2008/080374 (7 pages). [cited by applicant]
International Search Report dated Apr. 4, 2022 for International Application No. PCT/IB2021/060666 (9 pages). [cited by applicant]
Written Opinion of the International Searching Authority dated Apr. 4, 2022 for International App. No. PCT/IB2021/060666 (13 pages). [cited by applicant]
Extended European Search Report dated Jun. 16, 2020 for EP App. No. 20160043.4 (10 pages). [cited by applicant]
Extended European Search Report dated Aug. 17, 2020 for EP App. No. 20162101.8 (7 pages). [cited by applicant]
Office Action and English Translation issued in CN Patent App. No. 201610236526.9 on Sep. 3, 2020 (9 Pages). [cited by applicant]