IP Library › Granted Patent US 12,329,883
Granted Patent B2
US 12,329,883 · App. 16/755,219 · Granted Jun 17, 2025

Soft tissue repair implants comprising hydroxybutyrate

Inventors: Peter Maughan Crapo (North Kingstown, RI); Devang Vijay Shah (Franklin, MA); Stephen F. Badylak (Pittsburgh, PA); George Hussey (Cranberry Township, PA); Catalina Pineda Molina (Pittsburgh, PA); Brian Sicari (Pittsburgh, PA)
Assignees: Davol Inc.; University of Pittsburgh—Of the Commonwealth System of Higher Education
A61L27/54A61K31/191A61L27/56A61L27/58A61L2300/21A61L2300/404A61L2430/30A61L2430/34
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Quick Facts
Patent No.
US 12,329,883
App. No.
16/755,219
Granted
Jun 17, 2025
Kind
B2
Abstract

Articles and methods involving soft tissue repair implants comprising 2-hydroxybutyrate, 3-hydroxybutyrate, 4-hydroxybutyrate, and/or their conjugate acids are generally provided. The 2-hydroxybutyrate, 3-hydroxybutyrate, 4-hydroxybutyrate, and/or the conjugate acid(s) of 2-hydroxybutyrate, 3-hydroxybutyrate, and 4-hydroxybutyrate may be provided in a therapeutically-effective amount for reducing or preventing microbial infection.

Claims (24)

1. A soft tissue repair implant, comprising:

a polymeric material;

a body portion comprising the polymeric material, wherein the body portion is in the form of a three-dimensional shape, a planar shape, or a combination of a three-dimensional shape and a planar shape, and

at least one of a hydroxybutyrate and a conjugate acid of a hydroxybutyrate in a therapeutically-effective amount for reducing or preventing microbial infection, wherein the at least one of a hydroxybutyrate and a conjugate acid of a hydroxybutyrate is part of the body portion and/or is a component of a coating disposed on the body portion,

wherein the soft tissue repair implant is configured to repair a soft tissue defect, and

wherein the at least one of the hydroxybutyrate or the conjugate acid of the hydroxybutyrate is a monomer that is not covalently bonded to any other species.

2. A soft tissue repair implant as in claim 1 , wherein the at least one of the hydroxybutyrate and the conjugate acid of the hydroxybutyrate is the hydroxybutyrate and is in the form of a salt.

3. A soft tissue repair implant as in claim 1 , wherein the soft tissue repair implant comprises the conjugate acid of the hydroxybutyrate.

4. A soft tissue repair implant as in claim 1 , wherein the at least one of the hydroxybutyrate and the conjugate acid of the hydroxybutyrate is 4-hydroxybutyrate or a conjugate acid of 4-hydroxybutyrate.

5. A soft tissue repair implant as in claim 1 , wherein the at least one of the hydroxybutyrate and the conjugate acid of the hydroxybutyrate is 2-hydroxybutyrate or a conjugate acid of 2-hydroxybutyrate.

6. A soft tissue repair implant as in claim 1 , wherein the at least one of the hydroxybutyrate and the conjugate acid of the hydroxybutyrate is 3-hydroxybutyrate or a conjugate acid of 3-hydroxybutyrate.

7. A soft tissue repair implant as in claim 1 , wherein the body portion includes a fabric portion.

8. A soft tissue repair implant as in claim 1 , wherein the body portion comprises at least one of a knit fabric, a woven fabric, a non-woven fabric, and a braided fabric.

9. A soft tissue repair implant as in claim 1 , wherein the body portion comprises pores.

10. A soft tissue repair implant as in claim 1 , wherein a thickness of a layer comprising the at least one of hydroxybutyrate and the conjugate acid of the hydroxybutyrate is greater than or equal to 50 nm and less than or equal to 1 cm.

11. A soft tissue repair implant as in claim 1 , wherein at least a portion of the soft tissue repair implant is non-resorbable.

12. A soft tissue repair implant as in claim 1 , wherein at least a portion of the soft tissue repair implant is resorbable.

13. A soft tissue repair implant as in claim 1 , wherein the soft tissue repair implant comprises a natural material.

14. A soft tissue repair implant as in claim 1 , wherein the soft tissue repair implant comprises a synthetic material.

15. A soft tissue repair implant as in claim 1 , wherein at least a portion of the soft tissue repair implant is tissue infiltratable.

16. A soft tissue repair implant as in claim 1 , wherein at least a portion of the soft tissue repair implant is not tissue infiltratable.

17. A soft tissue repair implant as in claim 1 , wherein the therapeutically-effective amount of the at least one of hydroxybutyrate and the conjugate acid of the hydroxybutyrate is a component of a coating disposed on the body portion.

18. A soft tissue repair implant as in claim 17 , wherein the body portion comprises fibers, and wherein the coating conformally coats at least a portion of the fibers.

19. A soft tissue repair implant as in claim 1 , wherein the soft tissue repair implant is a soft tissue repair prosthesis.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2020
From: BADYLAK, STEPHEN F.; HUSSEY, GEORGE; MOLINA, CATALINA PINEDA; SICARI, BRIAN
To: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 053252/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2020
From: CRAPO, PETER MAUGHAN; SHAH, DEVANG VIJAY
To: DAVOL INC.
Reel/Frame 053252/0914 →
Continuity (2)
Provisional Application 62576403 · Oct 24, 2017
Related Publication 20200261624A1 · Aug 20, 2020
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