Lubricating block copolymers and their use as biomimetic boundary lubricants
The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block.
1. A block copolymer having the following structure:
wherein:
X is selected from —NR′—, —O—, and a bond, wherein R′ is selected from hydrogen atom and hydrocarbon groups having at least one and up to six carbon atoms;
Y is selected from polyalkylene glycol, saccharide, and polyalcohol;
R is a cartilage binding domain;
subscripts d and e are independently integers of at least 3; and
subscript f is 0 or an integer of at least 1;
wherein the hydrogen atom on the shown carboxylic acid group is optionally replaced with a positively charged metal ion or positively charged organic group; and
wherein, by the laws of chemistry, the block copolymer is terminated on the end opposite to the thiol group by a terminal group.
2. The block copolymer of claim 1 , wherein Y is a saccharide.
3. The block copolymer of claim 2 , wherein said saccharide is a monosaccharide or polysaccharide.
4. A block copolymer having the following structure:
wherein:
X is selected from —NR′—, —O—, and a bond, wherein R′ is selected from hydrogen atom and hydrocarbon groups having at least one and up to six carbon atoms;
Y is selected from saccharides and sugar alcohols;
R is a hydrogen atom, hydrocarbon group having 1-12 carbon atoms, or a cartilage binding domain;
subscripts d and e are independently integers of at least 3; and
subscript f is 0 or an integer of at least 1;
wherein the hydrogen atom on the shown carboxylic acid group is optionally replaced with a positively charged metal ion or positively charged organic group; and
wherein, by the laws of chemistry, the block copolymer is terminated on the end opposite to the thiol group by a terminal group.
5. A method for imparting a suitable level of lubricity to a biological tissue, the method comprising contacting said biological tissue with a sufficient amount of a composition to impart suitable lubricity, said composition comprising a block copolymer having the following structure:
X is selected from —NR′— and —O—, wherein R′ is selected from hydrogen atom and hydrocarbon groups having at least one and up to six carbon atoms;
Y is selected from polyalkylene glycol, saccharide, and polyalcohol;
R is a cartilage binding domain;
subscripts d and e are independently integers of at least 3; and
subscript f is 0 or an integer of at least 1;
wherein the hydrogen atom on the shown carboxylic acid group is optionally replaced with a positively charged metal ion or positively charged organic group; and
wherein, by the laws of chemistry, the block copolymer is terminated on the end opposite to the thiol group by a terminal group.
6. The method of claim 5 , wherein said biological tissue is selected from joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue.