IP Library › Granted Patent US 12,364,720
Granted Patent B2
US 12,364,720 · App. 18/471,658 · Granted Jul 22, 2025

Patent

Inventors: Derrick Lewis (Durham, NC); Marianne Thorup Cohn (Copenhagen, DK); Adam Nelson (Salem, VA); Preben Nielsen (Horsholm, DK)
Assignee: Novozymes A/S
A61K35/742A23K10/18A23K50/75A61P31/04C12N1/20C12N1/205C12R2001/07
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Quick Facts
Patent No.
US 12,364,720
App. No.
18/471,658
Granted
Jul 22, 2025
Kind
B2
Abstract

Bacillus strains useful for preventing and/or controlling Clostridium perfringens infections and necrotic enteritis in monogastric animals, such as swine and poultry, and for improving the overall health, feed conversion rates and body weight gain of such animals, as well as compositions comprising the Bacillus strains and various methods of using the Bacillus strains in animal feed and animal feed additives.

Claims (23)

1. A method comprising administering one or more Bacillus strains to an animal, said one or more Bacillus strains comprising:

Bacillus amyloliquefaciens DSM 29869,

Bacillus subtilis DSM 29871, and/or

Bacillus amyloliquefaciens DSM 29872.

2. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as dried spores.

3. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as part of a composition comprising between 1×10 4 and 1×10 18 colony forming units of said one or more Bacillus strains per kilogram of said composition.

4. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as part of a composition comprising one or more enzymes.

5. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as part of a composition comprising one or more feed ingredients.

6. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as part of a composition comprising one or more vitamins.

7. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as part of a composition comprising one or more flowability agents.

8. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as part of a composition comprising one or more additional microbes.

9. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal as part of a composition comprising extruded animal feed pellets.

10. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal in an amount sufficient to improve one or more performance parameters of said animal, as compared to that of a control animal that was not administered said one or more Bacillus strains.

11. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal in an amount sufficient to improve body weight gain of said animal, as compared to that of a control animal that was not administered said one or more Bacillus strains.

12. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal in an amount sufficient to improve a feed conversion ratio of said animal, as compared to that of a control animal that was not administered said one or more Bacillus strains.

13. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal in an amount sufficient to improve a feed efficiency of said animal, as compared to that of a control animal that was not administered said one or more Bacillus strains.

14. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal in an amount sufficient to reduce one or more symptoms of Clostridium perfringens infection in said animal.

15. The method of claim 1 , wherein said one or more Bacillus strains is/are administered to said animal in an amount sufficient to reduce one or more symptoms of necrotic enteritis in said animal.

16. The method of claim 1 , wherein said animal is a poultry animal.

17. The method of claim 1 , wherein said animal is a swine animal.

18. The method of claim 1 , wherein said one or more Bacillus strains comprises Bacillus amyloliquefaciens DSM 29869.

19. The method of claim 1 , wherein said one or more Bacillus strains comprises Bacillus subtilis DSM 29871.

20. The method of claim 1 , wherein said one or more Bacillus strains comprises Bacillus amyloliquefaciens DSM 29872.

Continuity (5)
Division 17500606 · Oct 13, 2021
Continuation 15542161
Provisional Application 62106892 · Jan 23, 2015
Provisional Application 62260882 · Nov 30, 2015
Related Publication 20240075077A1 · Mar 7, 2024
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Cited By (1)
US 12,742,146