Granted Patent B2

US 12,370,079 · App. 17/127,431 · Granted Jul 29, 2025

Inventors: Stephen R. Popielarski (Devon, PA); Changfeng Tai (Wexford, PA); Grant M. Chapman (Indianapolis, IN)

Assignees: Thermaquil, Inc.; University of Pittsburgh—Of the Commonwealth System of Higher Education

A61F7/007A61F7/0085A61N1/403A61N5/025A61N5/0622A61N5/0625A61F2007/0007A61F2007/0054A61F2007/0056A61F2007/0071A61F2007/0075A61F2007/0086A61F2007/0096A61N2005/0659

Abstract

Claims (31)

1. A method comprising:

delivering thermal energy to a treatment portion of a target nerve in a body of a subject mammal via a thermal applicator disposed in operative relationship with the treatment portion to increase a temperature of the treatment portion to a first temperature above a physiologic temperature of the target nerve, the target nerve being a C-fiber nerve and/or an A-δ fiber nerve, carrying pain signals;

continuing to deliver thermal energy to the treatment portion via the thermal applicator to maintain the temperature of the treatment portion at the first temperature for a first duration sufficient to pre-condition the target nerve;

ceasing delivery of thermal energy to the treatment portion;

the continuing to deliver thermal energy and the ceasing delivery of thermal energy being such that after the ceasing delivery a withdrawal of thermal energy to a second temperature can achieve a blockade of the target nerve, the second temperature being below the physiologic temperature of the target nerve by a first degree, the second temperature being higher than a third temperature that is below the physiologic temperature of the target nerve by a second degree greater than the first degree and required to be achieved, via withdrawal of thermal energy, for a blockade of the target nerve in an absence of the pre-condition,

the first temperature being sufficient to pre-condition the target nerve or initiate a reversible, partial blockade of the target nerve, and insufficient to pre-condition or initiate a reversible, partial blockade of an A-β fiber, that is myelinated and carrying motor signals and having a portion in proximity to the treatment portion of the target nerve;

withdrawing thermal energy from the treatment portion via the thermal applicator to decrease a temperature of the treatment portion to the second temperature below the physiologic temperature of the target nerve; and

continuing to withdraw thermal energy from the treatment portion via the thermal applicator to maintain the temperature of the treatment portion at the second temperature for a second duration sufficient to achieve a reversible blockade of the target nerve, before the target nerve has recovered from the pre-condition or reversible partial blockade, without inducing a blockade of the A-β fiber that is myelinated and carrying motor signals and having the portion in proximity to the treatment portion of the target nerve.

2. The method of claim 1 , wherein the first temperature is between about 42° C. and about 45° C.

3. The method of claim 2 , wherein the first duration is between about 5 minutes and about 180 minutes.

4. The method of claim 2 , wherein the first duration is between about 5 minutes and about 60 minutes.

5. The method of claim 1 , wherein the second temperature is between about 15° C. and about 30° C.

6. The method of claim 5 , wherein the second duration is between about 5 minutes and about 60 minutes.

7. An apparatus comprising:

a thermal energy source;

a thermal energy sink;

a thermal energy conduit coupled to the thermal energy source and to the thermal energy sink;

a thermal applicator coupled to the thermal energy conduit and configured:

to be applied topically to a skin overlying a treatment portion of a target nerve in a treatment location on a body of a subject mammal, the target nerve being a C-fiber nerve and/or an A-δ fiber nerve, carrying pain and/or other undesired sensory signals,

to receive thermal energy from the thermal energy source via the thermal energy conduit and to deliver the thermal energy to the treatment portion of the target nerve, and

to receive thermal energy from the treatment portion of the target nerve and convey it to the thermal energy sink via the thermal energy conduit; and

a controller operatively coupled to the energy source and the thermal energy sink, and configured:

to cause the energy source to provide energy to the thermal applicator via the energy conduit at a temperature and thermal energy delivery rate sufficient to raise the temperature of the treatment portion of the target nerve to a first temperature above a physiologic temperature and to maintain the first temperature for a first duration sufficient to pre-condition the target nerve,

to cease delivery of thermal energy, and

then to cause the thermal energy sink to cause thermal energy to be removed from the thermal applicator at a rate sufficient to lower the temperature of the treatment portion of the target nerve to a second temperature, below the physiologic temperature, sufficient to achieve a reversible blockade of the target nerve, the second temperature being below the physiologic temperature by a first degree, the second temperature being higher than a third temperature that is below the physiologic temperature of the target nerve by a second degree greater than the first degree and required to be achieved, via withdrawal of thermal energy, for a blockade of the target nerve in an absence of the pre-condition.

8. The apparatus of claim 7 , wherein the thermal energy conduit includes a fluid conduit that is configured to have fluid circulated therethrough to convey thermal energy between the thermal applicator and the thermal energy source and the thermal energy sink.

9. The apparatus of claim 7 , wherein the controller is configured to cause the energy source and the thermal energy sink to operate in accordance with the method of claim 1 .

10. The apparatus of claim 7 , wherein the thermal energy source is a thermoelectric heater.

11. The apparatus of claim 7 , wherein the thermal energy sink is a thermoelectric cooler.

12. The method of claim 1 , wherein the thermal applicator is applied topically to a skin overlying the treatment portion of the target nerve in the body of the subject mammal.

13. The method of claim 1 , wherein at least one of the delivering thermal energy to the treatment portion of the target nerve or the withdrawing thermal energy from the treatment portion of the target nerve is performed using a thermoelectric heater or a thermoelectric cooler, respectively.

Assignments (3)

Continuity (5)

References Cited (159)