IP Library › Granted Patent US 12,371,425
Granted Patent B2
US 12,371,425 · App. 17/946,101 · Granted Jul 29, 2025

Benzisoxazole sulfonamide derivatives

Inventors: Ylva Elisabet Bergman Bozikis (Parkville, AU); Michelle Ang Camerino (Parkville, AU); Pei-Pei Kung (San Diego, CA); Paul Anthony Stupple (Melbourne, AU); Scott Channing Sutton (San Diego, CA)
Assignees: Pfizer Inc.; CTXT PTY LTD
C07D413/06A61P35/04A61K45/06C07B2200/13
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Quick Facts
Patent No.
US 12,371,425
App. No.
17/946,101
Granted
Jul 29, 2025
Kind
B2
Abstract

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, R 1 -R 8 , and n are defined herein. The novel benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

Claims (5)

1. A method of treating cancer in a patient comprising administering to the patient an amount of a compound

or a pharmaceutically acceptable salt thereof, effective to result in a decrease in severity of cancer symptoms.

2. The method of claim 1 , wherein the cancer is breast cancer.

3. The method of claim 1 , wherein the cancer is ER positive breast cancer.

4. The method of claim 2 , wherein the breast cancer is ER+ HER2− breast cancer.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 29, 2024
From: BRODSKY, OLEG; GREASLEY, SAMANTHA ELIZABETH; HOFFMAN, ROBERT LOUIS; KUMPF, ROBERT ARNOLD; KUNG, PEI-PEI; RICHARDSON, PAUL FRANCIS; SUTTON, SCOTT CHANNING
To: PFIZER INC.
Reel/Frame 068110/0062 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 29, 2024
From: MONASH UNIVERSITY
To: CTXT PTY LTD
Reel/Frame 068110/0254 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 29, 2024
From: BOZIKIS, YLVA ELISABET BERGMAN; CAMERINO, MICHELLE ANG; STUPPLE, PAUL ANTHONY
To: MONASH UNIVERSITY; CTXT PTY LTD
Reel/Frame 068172/0205 →
CHANGE OF ADDRESS Recorded Apr 19, 2023
From: PFIZER INC.
To: PFIZER INC.
Reel/Frame 063373/0960 →
Continuity (5)
Continuation 16902515 · Jun 16, 2020
Provisional Application 63025278 · May 15, 2020
Provisional Application 62953223 · Dec 24, 2019
Provisional Application 62863199 · Jun 18, 2019
Related Publication 20230174522A1 · Jun 8, 2023
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