Methods of using high-voltage catheters for microsecond or sub-microsecond pulsing
Flexible catheters adapted to be inserted into a body to deliver high-voltage, fast (e.g., microsecond, sub-microsecond, nanosecond, picosecond, etc.) electrical energy to target tissue may include a plurality of conductive layers, that may be coaxial. These catheters and method of using them to treat tissue are configured to reduce or avoid arcing.
1. A method of treating cardiac tissue, the method comprising:
applying a plurality of microsecond or sub-microsecond electrical pulses having an amplitude of greater than 0.1 kV to a catheter inserted into a body of a subject through a first conductive layer extending at least partially down a length of the catheter and through a second conductive layer extending coaxial to the first conductive layer;
delivering the plurality of electrical pulses to the body of the subject from a first ablation electrode at a distal end region of the catheter in electrical communication with the first conductive layer and a second ablation electrode in electrical communication with the second conductive layer;
wherein configuration and spacing between the first and second conductive layers are such that a field generated from the first and the second conductive layers is cancelled to reduce or prevent electromagnetic interference (EMI) arising from the first and second conductive layers at high voltage and short pulse duration.
2. The method of claim 1 , the method comprising ablating epicardial, endocardial and/or pericardial tissue.
3. The method of claim 1 , wherein the plurality of electrical pulses is high-voltage nanosecond or picosecond pulses.
4. The method of claim 1 , the method comprising ablating the cardiac tissue with the plurality of electrical pulses having electric field strength between about 1 kV/cm and 100 kV/cm.
5. The method of claim 1 , further comprising connecting the catheter to a pulse generator using a high-voltage connector.
6. The method of claim 1 , wherein the first electrode and the second electrode are separated by an electrically insulating material to at least a minimum separation distance.
7. The method of claim 6 , wherein the first and/or the second electrodes are on a balloon and the electrically insulating material is a balloon material.
8. The method of claim 1 , comprising injecting saline into a ventricle through a lumen of the catheter.
9. The method of claim 1 , wherein the first electrode comprises a single electrode or a group of electrodes.
10. The method of claim 1 , further comprising periodically or continuously checking an impedance between the first electrode and the second electrode to determine whether a location of the first and second electrodes is outside of a target tissue.
11. The method of claim 1 , comprising delivering a visualization fluid including a contrast agent and a dye.
12. The method of claim 1 , comprising applying a vacuum through a lumen of the catheter.
13. The method of claim 1 , comprising perfusing a target tissue through a lumen of the catheter.
14. The method of claim 1 , wherein the first and/or the second electrode comprises one or more of a needle electrode, a plate electrode, a ring electrode, a surface electrode, a knife electrode, or a band electrode.
15. The method of claim 1 , the method comprising connecting a high-voltage connector to the first conductive layer and the second conductive layer.
16. The method of claim 1 , the method comprising inflating an inflatable balloon at the distal end region of the catheter.
17. The method of claim 1 , wherein at least one of the applying and delivering is performed by a robotic system.
18. The method of claim 1 , wherein at least one of the first electrode and the second electrode comprises one or more sets of electrodes and wherein the method comprises actuating the one or more sets of electrodes separately.
19. The method of claim 1 , wherein at least one of the first electrode and the second electrode comprising a distal-facing electrode at a distal end of the catheter.
20. The method of claim 1 , wherein reducing or preventing EMI comprises delivering the plurality of pulses from the first electrode and the second electrode, wherein the first and second conductive layers are arranged to reduce electrical loop area to prevent radiation of energy.
21. The method of claim 1 , wherein reducing or preventing EMI comprises maintaining a coaxial impedance between the first and second conductive layers at 200 Ohms or greater.
22. The method of claim 1 , wherein the first and second conductive layers are each formed of a combination of a conductive and insulative material.
23. The method of claim 1 , further comprising maintaining the reduction in EMI while improving structural mechanical properties of the catheter with at least the first conductive layer comprising a plurality of wires.
24. A method of treating cardiac tissue, the method comprising:
applying a plurality of high-voltage microsecond, nanosecond or picosecond electrical pulses having an amplitude of greater than 0.1 kV to a catheter inserted into a body of a subject through a first conductive layer extending at least partially down a length of the catheter and through a second conductive layer extending coaxial to the first conductive layer;
delivering the plurality of electrical pulses to the body of the subject from a first ablation electrode at a distal end region of the catheter in electrical communication with the first conductive layer and a second ablation electrode in electrical communication with the second conductive layer; and
cancelling a field generated from the first and the second conductive layers based on configuration and spacing between the first and the second conductive layers to reduce or prevent electromagnetic interference (EMI) arising from the first and second conductive layers at high voltage and short pulse duration and reducing an electrical loop area between the first and second conductive layers to prevent radiation of energy from the catheter.