IP Library › Granted Patent US 12,399,099
Granted Patent B2
US 12,399,099 · App. 18/491,034 · Granted Aug 26, 2025

Particle characterization

Inventors: Jason Corbett (Malvern, GB); Alex Malm (Malvern, GB)
Assignee: Malvern Panalytical Limited
G01N15/0211G01N2015/0222
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Quick Facts
Patent No.
US 12,399,099
App. No.
18/491,034
Granted
Aug 26, 2025
Kind
B2
Abstract

A method of characterising particles in a sample, comprising: obtaining a scattering measurement comprising a time series of measurements of scattered light from a detector, the scattered light produced by the interaction of an illuminating light beam with the sample; producing a corrected scattering measurement, comprising compensating for scattering contributions from contaminants by reducing a scattering intensity in at least some time periods of the scattering measurement; determining a particle characteristic from the corrected scattering measurement.

Claims (26)

1. A method of characterising particles in a sample, comprising:

obtaining a scattering measurement comprising a time series of measurements of scattered light from a detector, the scattered light produced by the interaction of an illuminating light beam with the sample;

producing a corrected scattering measurement, comprising compensating for scattering contributions from contaminants by reducing a scattering intensity in at least some time periods of the scattering measurement;

determining a particle characteristic from the corrected scattering measurement,

wherein reducing the scattering intensity comprises determining a model of scattering contributions from contaminants, and then subtracting the model from the scattering measurement.

2. The method of claim 1 , wherein reducing the scattering intensity comprises modifying a recorded scattering measurement.

3. The method of claim 1 , wherein the model comprises low-pass filtered version of the scattering measurement.

4. The method of claim 3 , wherein the low-pass filtered version comprises a moving average or a Savitsky Golay filter.

5. The method of claim 1 , wherein the model comprises a smoothed version of the scattering measurement.

6. The method of claim 5 , wherein the operation comprises a moving average or a Savitsky Golay filter.

7. The method of claim 1 , wherein the model comprises a fit to the scattering measurement.

8. The method of claim 1 , wherein producing a corrected scattering measurement comprises producing a composite autocorrelation function by combining part of a raw autocorrelation function derived from the uncorrected scattering measurement with part of an adjusted autocorrelation function derived from an adjusted scattering measurement, in which scattering intensity in at least one time period has been reduced to compensate for scattering contributions from contaminants.

9. The method of claim 8 , wherein the part of the raw autocorrelation function corresponds with delay times that are shorter than or equal to a selected delay time, and the part of the adjusted autocorrelation function corresponds with delay times that are longer than or equal to the selected delay time.

10. The method of claim 9 , comprising normalising the raw autocorrelation function so that the composite autocorrelation function is continuous at the selected delay time.

11. The method of claim 9 , wherein the selected delay time is in the range of 50 to 200 micro-seconds.

12. The method of claim 9 , wherein the selected delay time is determined to cause the gradient of a linear region of the raw autocorrelation function to match a gradient of the same linear region of the adjusted autocorrelation function at the selected delay time.

13. The method of claim 1 , wherein the scattering measurement comprises a sequence of photon pulses, and reducing the scattering intensity comprises deleting photon pulses from the sequence.

14. The method of claim 13 , wherein deleting photon pulses from the sequence comprises binning the sequence of photon pulses, and correcting selected bins by deleting a number of photon pulses from each selected bin.

15. The method of claim 14 , wherein the model comprises an estimate of the number of photon pulses in each bin due to scattering from a contaminant, and correcting the selected bins comprises deleting a number of photon pulses based on the estimate for each selected bin.

16. An apparatus for characterising particles, comprising: a light source, a sample cell, a detector and a processor; wherein

the light source is operable to illuminate a sample within the sample cell with a light beam so as to produce scattered light by interactions of the light beam with the sample;

the detector is configured to detect the scattered light and produce a time series of measurements; and

the processor is configured to:

obtain a scattering measurement comprising a time series of measurements of the scattered light from the detector;

produce a corrected scattering measurement, comprising compensating for scattering contributions from contaminants by reducing a scattering intensity in at least some time periods of the scattering measurement;

determine a particle characteristic from the corrected scattering measurement, wherein reducing the scattering intensity comprises determining a model of scattering contributions from contaminants, and then subtracting the model from the scattering measurement.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2025
From: CORBETT, JASON; MALM, ALEX
To: MALVERN PANALYTICAL LIMITED
Reel/Frame 070181/0961 →
Priority Claims (1)
EP 17162676 · Mar 23, 2017 · regional
Continuity (3)
Continuation 17531021 · Nov 19, 2021
Continuation 16496027
Related Publication 20240192108A1 · Jun 13, 2024
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