Osmolar devices and methods for preventing tissue swelling
Disclosed herein are devices and methods for the treatment and prevention of tissue swelling. The method involves creating an opening in a patient's skull and placement of a device in the patient's brain. The device is configured to absorb fluid from the patient's brain, thereby reducing intracranial pressure. Additionally, the device may be configured to induce an osmotic pressure to drive out fluid from the brain to reduce intracranial pressure. These methods and devices provide for a localized solution to tissue swelling and accordingly obviate the need to flood patients' vascular systems with osmolar compounds that may lead to well-documented side effects.
1. A device for treating brain swelling, said device occupying a device volume, said device comprising:
a solid comprising:
a semipermeable membrane; and
solute particles enclosed in said semipermeable membrane;
wherein said device is configured such that upon at least partial submersion of said solid in a brain fluid, said solute particles cause an osmotic gradient such that a portion of said brain fluid flows into said solid through said semipermeable membrane.
2. The device of claim 1 , wherein said solute particles are part of a solution.
3. The device of claim 2 , wherein said solution has an osmolarity greater than or equal to 300 mOsm/L.
4. The device of claim 2 , wherein said device has an osmolarity between 600 mOsm/L and 1200 mOsm/L.
5. The device of claim 1 , wherein said semipermeable membrane is substantially spherical.
6. The device of claim 1 , wherein said semipermeable membrane is substantially cylindrical.
7. The device of claim 1 , configured such that upon said portion of said brain fluid flowing into said solid, the device volume increases less than a volume of said portion of said brain fluid flowing into said solid.
8. The device of claim 1 , wherein said device is configured for at least partial submersion in brain fluid.
9. The device of claim 8 , wherein said solute particles are part of a solution, wherein said brain fluid has a brain fluid concentration of solute particles, and wherein a concentration of said solute particles in said solution is higher than said brain fluid concentration of solute particles.
10. The device of claim 1 , wherein upon absorption of said portion of said brain fluid, said device volume increases less than a volume of said portion of said fluid.
11. A method for treating brain swelling, comprising:
forming an opening in a skull of a patient having a brain, wherein said opening is adjacent to a portion of said brain, said portion having excess fluid; and
inserting a device into said opening, wherein said device is configured to absorb an absorbed amount of a fluid from said portion of said brain;
wherein said device comprises:
a solid comprising:
a semipermeable membrane; and
solute particles enclosed in said semipermeable membrane;
wherein said device is configured such that upon said insertion and at least partial submersion of said solid in said fluid, said solute particles cause an osmotic gradient such that said absorbed amount of said fluid flows into said solid through said semipermeable membrane.
12. The method of claim 1 , wherein said portion of said brain is damaged.
13. The method of claim 1 , wherein said device has an osmolarity greater than the osmolarity of said fluid.
14. The method of claim 1 , wherein said device is configured to, upon absorption of said absorbed amount of said fluid, expand less than the original volume of said absorbed amount of said fluid.
15. The method of claim 1 , wherein said device comprises a stent, and further comprising inserting said stent into a blood vessel of said brain.
16. The method of claim 15 , wherein said stent comprises a material with an osmolarity greater than the osmolarity of said fluid.
17. The method of claim 15 , wherein said stent comprises a biodegradable material.
18. The method of claim 1 , wherein absorption of said absorbed amount of fluid from said brain causes an increase in internal pressure of said device.