Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
The present invention relates to a protective solution for preventing or reducing reperfusion injury of the brain which contains magnesium ions and which has an osmolality of 350 to 600 mOsm/L, a pH value of 6.8 to 7.8 and albumin in an amount of 1 to 20% by weight.
1. A protective solution for reducing reperfusion injury of the brain comprising magnesium ions, sugar alcohol in an amount of 1-65 g/l, and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 460 to 650 mOsm/L and a pH value of 6.8 to 7.3.
2. The protective solution according to claim 1 , characterized in that it contains a sugar alcohol in an amount of 1-50 g/l.
3. The protective solution according to claim 2 , characterized in that the sugar alcohol is mannitol.
4. The protective solution according to claim 1 , characterized in that the sugar alcohol is mannitol.
5. The protective solution according to claim 1 , characterized in that it contains 5,000 to 50,000 IU heparin per liter of solution.
6. The protective solution according to claim 5 , characterized in that it contains 10,000 to 50,000 IU heparin per liter of solution.
7. The protective solution according to claim 1 , characterized in that the albumin is human serum albumin.
8. The protective solution according to claim 1 , characterized in that it contains lidocaine in an amount of 0.05-1 g per 1 of solution.
9. The protective solution according to claim 1 , characterized in that the magnesium is present in a concentration of 0.1 to 15 mmol/l.
10. The protective solution according to claim 1 , characterized in that it contains citrate ions in a concentration of 20 to 100 mmol/l solution.
11. The protective solution according to claim 1 , characterized in that it contains Cyclosporin in an amount of 50 mg to 1300 mg per liter of protective solution.
12. The protective solution according to claim 1 , wherein the solution comprises less than 0.5 mmol/l calcium ions.
13. The protective solution according to claim 1 , characterized in that it contains albumin in an amount of 5 to 10% by weight.
14. A method for reducing reperfusion injury of the brain after cardiopulmonary resuscitation comprising administering a protective solution comprising magnesium ions, sugar alcohol in an amount of 1-65 g/l, and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 460 to 650 mOsm/L and a pH value of 6.8 to 7.3.
15. The method of claim 14 , wherein said protective solution further contains 0.1-25.0 mmol potassium per liter of solution.
16. The method of claim 14 , wherein said protective solution contains a sugar alcohol in an amount of 1-50 g/l.
17. The method of claim 16 , wherein said sugar alcohol is mannitol.
18. The method of claim 14 , wherein said sugar alcohol is mannitol.
19. The method of claim 14 , wherein said protective solution contains 5,000 to 50,000 IU heparin per liter of solution.