IP Library › Granted Patent US 12,419,898
Granted Patent B2
US 12,419,898 · App. 17/496,814 · Granted Sep 23, 2025

Synergistic composition for maintenance of healthy balance of microflora

Inventors: Jingru Li (Milton, GA); Lindsay Adrienne Peed (Peachtree Corners, GA); Cheryce Francina Joyner (Tallahassee, FL); Rebecca Ann Vongsa (Neenah, WI); David William Koenig (Menasha, WI); Ryan Daniel Bartell (Appleton, WI); Paige Nicole Hollmaier (Neenah, WI)
Assignee: Kimberly-Clark Worldwide, Inc.
A61K31/7004A61K9/0034A61K31/194A61K31/70A61K31/7016A61K31/724A61P15/02A61K31/732A61K31/733A61K2300/00Y02A50/30
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Quick Facts
Patent No.
US 12,419,898
App. No.
17/496,814
Granted
Sep 23, 2025
Kind
B2
Abstract

The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract which could lead to inhibition of vaginal infections, as well as methods of treating and preventing vaginal infections. Compositions useful in supporting healthy microflora, disclosed herein, generally comprise a therapeutic amount of a first saccharide and a therapeutic amount of a second saccharide or an organic acid. The saccharides may be, for example, a pentose, a disaccharide, a cyclodextrin, a pectic substance or a non-digestible polysaccharide. The organic acid may be, for example, malic acid.

Claims (5)

1. A method for maintaining or supporting a healthy microflora balance in the urogenital area of a patient in need thereof, the method comprising topically administering to the urogenital area of the patient a composition comprising a first therapeutic agent comprising dextrin and a second therapeutic agent comprising pectin, wherein the composition synergistically promotes the growth of L. crispatus relative to E. coli such that the therapeutic effect is greater than about 30.

2. The method of claim 1 , wherein the weight ratio of the first therapeutic and the second therapeutic agent is from about 1:1 to about 1:50.

3. The method of claim 1 , wherein a total amount of the first therapeutic agent and the second therapeutic agent comprises less than about 10.0 wt/vol % of the composition.

4. The method of claim 1 , wherein the first therapeutic agent comprises from about 0.1 to about 2.0 wt/vol %, the second therapeutic agent comprises from about 0.1 to about 2.0 wt/vol %.

5. The method of claim 1 , wherein administration of the composition increases Lactobacillus growth or activity in vivo.

Continuity (2)
Division 15758535
Related Publication 20220023322A1 · Jan 27, 2022
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