Granted Patent B2

US 12,440,231 · App. 18/204,133 · Granted Oct 14, 2025

Inventors: Maysa Mustafa (Zichron Yaakuv, IL); Maxim Vasylevytsky (Kefar-Sava, IL); Amir Belson (Savion, IL); Aviram Alfia (Karmiel, IL)

Assignee: CERETRIEVE LTD.

A61B17/221A61B2017/22074A61B2017/22079A61B2017/2215

Abstract

Claims (48)

1. A method of retrieving biological material from a blood vessel comprising:

advancing a distal part of a catheter system into the blood vessel while the catheter system is in a preconfigured delivery state in which a funnel-shaped sleeve of the catheter system is compressed within a catheter of the catheter system, the catheter system being preconfigured to have:

a partially-deployed state in which (i) a predetermined distal part of the funnel-shaped sleeve is disposed out of a distal opening of the catheter, and (ii) a predetermined intermediate part of the funnel-shaped sleeve and a predetermined proximal part of the funnel-shaped sleeve are disposed within the catheter,

a fully-deployed state in which (i) the distal part and the intermediate part are disposed out of the distal opening, and (ii) the proximal part is disposed within the catheter;

while the distal part of the catheter system remains in the blood vessel, transitioning the catheter system into the partially-deployed state by advancing the distal part of the funnel-shaped sleeve out of the distal opening;

while the catheter system remains in the partially-deployed state, applying suction to trap at least part of the biological material within the funnel-shaped sleeve; and

subsequently, transitioning the catheter system into the fully-deployed state by advancing the intermediate part out of the distal opening; and

while the catheter system remains in the fully-deployed state, applying further suction to draw more of the material into the funnel-shaped sleeve.

2. The method according to claim 1 , wherein transitioning the catheter system into the fully-deployed state comprises transitioning the catheter system into the fully-deployed state by advancing the intermediate part out of the distal opening while applying suction via the catheter system.

3. The method according to claim 1 , wherein the predetermined distal part has a predetermined length, and wherein advancing the predetermined distal part of the funnel-shaped sleeve out of the distal opening comprises advancing the funnel-shaped sleeve out of the distal opening until the length of the funnel-shape sleeve within the blood vessel is the predetermined length.

4. The method according to claim 3 , wherein the predetermined length is 2-8 mm.

5. The method according to claim 1 , wherein:

the distal part is biased to assume a conical shape, and

transitioning the catheter system into the partially-deployed state by advancing the distal part of the funnel-shaped sleeve out of the distal opening comprises transitioning the catheter system into the partially-deployed state by advancing the distal part of the funnel-shaped sleeve out of the distal opening such that the distal part assumes the conical shape within the blood vessel.

6. The method according to claim 5 , wherein:

the intermediate part is biased to assume a cylindrical shape, and

transitioning the catheter system into the fully-deployed state by advancing the intermediate part out of the distal opening comprises transitioning the catheter system into the fully-deployed state by advancing the intermediate part out of the distal opening such that, within the blood vessel, the intermediate part assumes the cylindrical shape while the distal part remains in the conical shape.

7. The method according to claim 1 , wherein the catheter system includes markings, and wherein transitioning the catheter system into the partially-deployed state comprises transitioning the catheter system into the partially-deployed state guided by the markings.

8. The method according to claim 7 , wherein:

the funnel-shaped sleeve includes radiopaque markers,

a distal tip of the catheter includes a radiopaque marker, and

transitioning the catheter system into the partially-deployed state comprises transitioning the catheter system into the partially-deployed state guided by the radiopaque markers.

9. The method according to claim 1 , wherein the proximal part of the funnel-shaped sleeve is attached to an inner shaft, the inner shaft extending, from the proximal part, proximally through the catheter to a handle of the catheter system, and wherein transitioning the catheter system into the partially-deployed state and the fully-deployed state comprises using the handle to move the inner shaft distally with respect to the catheter.

10. The method according to claim 9 , wherein the handle is actuatable to lock a position of the funnel-shaped sleeve with respect to the catheter.

11. The method according to claim 9 , wherein transitioning the catheter system into the partially-deployed state comprises actuating a mechanism on the handle to apply a preconfigured amount of force to the catheter system to move the funnel-shaped sleeve with respect to the catheter in a manner that (i) advances the distal part out of the catheter and (ii) retains the intermediate part within the catheter.

12. The method according to claim 9 , wherein:

the handle includes a mechanism that is switchable between a first discrete-state and a second discrete-state,

switching the mechanism between the first discrete-state and the second discrete-state transitions the catheter system from the preconfigured delivery state to the partially-deployed state,

advancing the distal part of the catheter system into the blood vessel while the catheter system is in the preconfigured delivery state comprises advancing the distal part of the catheter system into the blood vessel while the mechanism is in the first discrete-state, and

transitioning the catheter system into the partially-deployed state comprises switching the mechanism on the handle to the second discrete-state.

13. The method according to claim 12 , wherein:

the mechanism is further switchable between the second discrete-state and a third discrete-state,

switching the mechanism between the second discrete-state and the third discrete-state transitions the catheter system from the partially-deployed state to the fully-deployed state, and

transitioning the catheter system into the fully-deployed state comprises switching the mechanism on the handle to the third discrete-state.

14. The method according to claim 12 , wherein the mechanism defines a scale, each of the discrete-states being discrete positions on the scale, and wherein switching the mechanism to the second discrete-state comprises moving the mechanism between the discrete-states on the scale.

15. The method according to claim 12 , wherein the mechanism is a slider, and wherein switching the mechanism to the second discrete-state comprises sliding the slider along a track.

16. The method according to claim 15 , wherein the second discrete-state is facilitated by an indent that is adapted to inhibit sliding of the slider, and wherein switching the mechanism from the first discrete-state to the second discrete-state comprises sliding the slider along the track until the slider is inhibited from sliding distally by the indent.

17. The method according to claim 15 , wherein the slider is coupled to the inner shaft, and wherein transitioning the catheter system into the partially-deployed state by advancing the distal part of the funnel-shaped sleeve out of the distal opening comprises sliding the slider distally along the track such that the inner shaft slides distally within the catheter in a manner that advances the distal part out of the distal opening.

18. A method of retrieving biological material from a blood vessel comprising:

advancing a distal part of a catheter system into the blood vessel while the catheter system is in a preconfigured delivery state in which a funnel-shaped sleeve of the catheter system is compressed within a catheter of the catheter system;

while the distal part of the catheter system remains in the blood vessel, transitioning the catheter system into a preconfigured partially-deployed state by advancing a predetermined distal part of the funnel-shaped sleeve out of a distal opening of the catheter, such that an intermediate part of the funnel-shaped sleeve and a proximal part of the funnel-shaped sleeve remain within the catheter;

while the catheter system remains in the partially-deployed state, applying suction to trap at least part of the biological material within the funnel-shaped sleeve;

subsequently, transitioning the catheter system into a fully-deployed state by further advancing the funnel-shaped sleeve out the catheter such that the intermediate part extends out of the distal opening and the proximal part of the funnel-shaped sleeve remains within the catheter; and

while the catheter system remains in the fully-deployed state, applying further suction to draw more of the material into the funnel-shaped sleeve.

19. The method according to claim 18 , wherein:

the proximal part of the funnel-shaped sleeve is attached to an inner shaft that has a handle, the inner shaft extending, from the proximal part, proximally through the catheter to the handle,

the handle is actuatable to lock the funnel-shaped sleeve with respect to the catheter, and

transitioning the catheter system into the partially-deployed state and the fully-deployed state comprises using the handle to move the inner shaft distally with respect to the catheter.

Assignments (2)

Continuity (3)

References Cited (155)