IP Library › Granted Patent US 12,448,461
Granted Patent B2
US 12,448,461 · App. 17/050,424 · Granted Oct 21, 2025

ABCB5 ligands and substrates

Inventor: Markus H. Frank (Cambridge, MA)
Assignee: Children's Medical Center Corporation
C07K16/3053A61K31/6615C07F9/117C07K14/4702G01N33/5041C07K2317/21C07K2317/76
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Quick Facts
Patent No.
US 12,448,461
App. No.
17/050,424
Granted
Oct 21, 2025
Kind
B2
Abstract

The present invention is directed to methods and compositions for modulating ABCB5+ stem cell activity. The invention also relates to assays and reagents for manipulating and characterizing compounds that modulate ABCB5+ cell signaling.

Claims (6)

1. A composition comprising a synthetic phospholipid, comprising a compound having the structure:

wherein the phospholipid comprises two fatty acids, wherein each of the fatty acids comprises a carboxyl linked to a carbon atom chain identified by R 1 and R 2 and wherein R 1 and R 2 independent of one another have a length defined by a number of carbon atoms acid chains; and

wherein one of R 1 and R 2 has a length that is at least twice as long as the other of R 1 and R 2 , and wherein the phospholipid has a formula: C 33 H 65 Q 19 P 3 .

2. The composition of claim 1 , wherein the phospholipid comprises [PIP2 (6:0/18:0)-H] − and a pharmaceutically acceptable carrier.

3. A composition comprising a synthetic phospholipid, comprising a compound having the structure:

wherein the phospholipid comprises two fatty acids, wherein each of the fatty acids comprises a carboxyl linked to a carbon atom chain identified by R 1 and R 2 and wherein R 1 and R 2 independent of one another have a length defined by a number of carbon atoms acid chains; wherein one of R 1 and R 2 has a length that is at least twice as long as the other of R 1 and R 2 , and wherein the composition enhances ABCB5-PIP2 pathway.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2021
From: FRANK, MARKUS H.
To: CHILDREN'S MEDICAL CENTER CORPORATION
Reel/Frame 055955/0341 →
Continuity (2)
Provisional Application 62662670 · Apr 25, 2018
Related Publication 20210188999A1 · Jun 24, 2021
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