Granted Patent
B2
US 12,472,057 · App. 17/236,201 · Granted Nov 18, 2025
Tubular prostheses
Inventors:
Laura Niklason (Greenwich, CT); Angela Huang (New Haven, CT); Liping Zhao (New Haven, CT); Shannon Dahl (Palo Alto, CA)
A61F2/20A61L27/3633A61L27/3679A61L27/3687A61L27/3826A61L27/3882A61L27/48A61F2002/046A61L2430/22A61L2430/40
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Abstract
Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.
Claims (8)
1 . An artificial esophagus for replacement of damaged tissue by implantation, said artificial esophagus comprising:
substantially acellular, human extracellular matrix formed as a tube of greater than 10 mm diameter, wherein the artificial esophagus has a suture retention strength of greater than 150 grams.
2 . The artificial esophagus of claim 1 which is impermeable to food, liquid, and gas.
3 . The artificial esophagus of claim 2 which is populated with esophageal cells selected from the group consisting of epithelial cells, endothelial cells, smooth muscle cells, and fibroblasts.
4 . The artificial esophagus of claim 1 wherein the substantially acellular, human extracellular matrix was produced and secreted by human vascular smooth muscle cells.
5 . The artificial esophagus of claim 1 wherein greater than 30% of dry tissue weight of the artificial esophagus is collagen.
6 . The artificial esophagus of claim 1 which has a rupture strength of greater than 1000 mm Hg.
7 . The artificial esophagus of claim 1 which comprises a tubular stent.
Assignments (8)
RELEASE OF SECURITY INTEREST
Recorded Dec 16, 2025
From: HOOK SA LLC, AS PURCHASER AGENT
To: HUMACYTE GLOBAL, INC.
Reel/Frame 073234/0064 →
SECURITY INTEREST
Recorded Dec 15, 2025
From: HUMACYTE, INC.; HUMACYTE GLOBAL, INC.
To: AVENUE VENTURE OPPORTUNITIES FUND II, L.P., AS AGENT
Reel/Frame 073214/0250 →
SECURITY INTEREST
Recorded May 15, 2023
From: HUMACYTE GLOBAL, INC.
To: HOOK SA LLC, AS PURCHASER AGENT
Reel/Frame 063638/0933 →
CORRECTIVE ASSIGNMENT TO CORRECT THE FIRST ASSIGNEE'S NAME PREVIOUSLY RECORDED AT REEL: 055990 FRAME: 0839. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT .
Recorded May 4, 2021
From: NIKLASON, LAURA
To: HUMACYTE, INC.; YALE UNIVERSITY
Reel/Frame 056122/0887 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 055990 FRAME: 0786. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT .
Recorded May 4, 2021
From: DAHL, SHANNON
To: HUMACYTE, INC.
Reel/Frame 056122/0873 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 21, 2021
From: DAHL, SHANNON
To: HUMACYTE
Reel/Frame 055990/0786 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 21, 2021
From: NIKLASON, LAURA
To: HUMACYTE; YALE UNIVERSITY
Reel/Frame 055990/0839 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 21, 2021
From: HUANG, ANGELA; ZHAO, LIPING
To: YALE UNIVERSITY
Reel/Frame 055990/0806 →
Continuity (4)
Division
14351408
Provisional Application
61547350
· Oct 14, 2011
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