Method and device for treating eye disease
Described herein are devices used to treat high intraocular pressure and glaucoma. An example device includes a plate comprising a first surface opposite a second surface. The first surface includes a series of fluid channels. The device also includes a first coating on the first surface and a second coating on the second surface. The device is configured to lower intraocular pressure by draining aqueous humor from an anterior chamber to subconjunctival space of a patient's eye.
1 . A device for lowering intraocular pressure, the device comprising:
a plate having a first end and a second end, the plate comprising a first surface opposite a second surface, wherein the first surface includes a series of fluid channels configured in an intersecting grid pattern extending from the first end to the second end of the plate,
the first end of the plate being configured for insertion into an anterior chamber of an eye, and
the second end of the plate being configured for insertion into a subconjunctival space of the eye;
a first coating on the first surface that conforms to a topography of the series of fluid channels; and
a second coating on the second surface.
2 . The device according to claim 1 , wherein the plate includes a core that has a thickness of about 50 nm to about 800 nm.
3 . The device according to claim 1 , wherein the plate is formed from a ceramic material.
4 . The device according to claim 3 , wherein the ceramic material is selected from the group consisting of alumina, silicon nitride, silica, hafnium oxide, titanium nitride, and titanium carbide.
5 . The device according to claim 1 , wherein the first coating has a thickness of about 0.1 μm to about 1 μm.
6 . The device according to claim 1 , wherein the first coating is a parylene polymer.
7 . The device according to claim 6 , wherein the parylene polymer is parylene C, parylene D, parylene N, a derivative thereof, or a combination thereof.
8 . The device according to claim 1 , wherein the first coating is a polymeric material selected from rubber, synthetic rubber, silicone polymers, parylene, thermoplastics, thermosets, polyolefins, polyisobutylene, acrylic polymers, ethylene-co-vinylacetate, polybutylmethacrylate, vinyl halide polymers, polyvinyl ethers, polyvinylidene halides, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics, polyvinyl esters, acrylonitrile-styrene copolymers, ABS resins, ethylene-vinyl acetate copolymers, polyamides, alkyd resins, polycarbonates, polyoxymethylenes, polyimides, polyethers, epoxy resins, polyurethanes, rayon, cellulose, cellulose acetate, cellulose butyrate, cellulose acetate butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, carboxymethyl cellulose, polytetrafluororethylene, poly(ether-ether-ketone), poly lactides including PLA, PLGA, PLLA, derivatives thereof, or combinations thereof.
9 . The device according to claim 1 , wherein the second coating has a thickness of about 0.1 μm to about 1 μm.
10 . The device according to claim 1 , wherein the second coating is aluminum oxide or a parylene polymer.
11 . The device according to claim 1 , wherein the second coating includes aluminum oxide, rubber, synthetic rubber, silicone polymers, parylene, thermoplastics, thermosets, polyolefins, polyisobutylene, acrylic polymers, ethylene-co-vinylacetate, polybutylmethacrylate, vinyl halide polymers, polyvinyl ethers, polyvinylidene halides, polyacrylonitrile, polyvinyl ketones, polyvinyl aromatics, polyvinyl esters, acrylonitrile-styrene copolymers, ABS resins, ethylene-vinyl acetate copolymers, polyamides, alkyd resins, polycarbonates, polyoxymethylenes, polyimides, polyethers, epoxy resins, polyurethanes, rayon, cellulose, cellulose acetate, cellulose butyrate, cellulose acetate butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, carboxymethyl cellulose, polytetrafluororethylene, poly(ether-ether-ketone), poly lactides such as PLA, PLGA, PLLA, derivatives thereof, or combinations thereof.
12 . The device of claim 1 , wherein the series of fluid channels includes a plurality of open-ended channels interconnected to form an intersecting network of fluid pathways.
13 . The device of claim 1 , further including a drug.
14 . A method of reducing intraocular pressure comprising:
injecting a device into an eye with high intraocular pressure, the device including a plate having a first end and a second end, the plate comprising a first surface opposite a second surface, wherein the first surface includes a series of fluid channels configured in an intersecting grid pattern extending from the first end to the second end of the plate,
the first end of the plate being configured for insertion into an anterior chamber of the eye, and
the second end of the plate being configured for insertion into a subconjunctival space of the eye,
the plate further comprising a first coating on the first surface that conforms to a topography of the series of fluid channels and a second coating on the second surface; and
treating the high intraocular pressure.
15 . The method of claim 14 , further comprising securing the device to the eye.
16 . The method of claim 15 , wherein the securing is to a sclera of the eye.
17 . The method of claim 14 , wherein at least a portion of the first surface of the plate faces a conjunctiva of the eye and at least a portion of the second surface faces a sclera of the eye.
18 . The method of claim 17 , wherein the device forms a fluid pathway that provides fluid communication between the anterior chamber of the eye and a device position.
19 . The method of claim 18 , wherein the fluid pathway comprises the series of fluid channels.
20 . The method of claim 14 , wherein treating the high intraocular pressure is a treatment for glaucoma.