Granted Patent
B2
US 12,472,152 · App. 18/472,901 · Granted Nov 18, 2025
Molecular entrapment via homopolymer self-assembly
Inventors:
Evan A. Scott (Evanston, IL); Fanfan Du (Evanston, IL); Baofu Qiao (Evanston, IL); Monica Olvera de la Cruz (Evanston, IL)
Assignee:
Northwestern University
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Abstract
The present invention provides novel nanostructures comprising solution of PPSU 20 . Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
Claims (18)
1 . A method of loading a poly(propylene sulfone) (PPSU) homopolymer nanostructure with a cargo, the method comprising incubating the nanostructure with the cargo in a buffer for up to 5 minutes, thereby loading the nanostructure with the cargo.
2 . The method of claim 1 , wherein the incubating comprises vortexing the nanostructure and the cargo.
3 . The method of claim 1 , wherein the buffer comprises phosphate buffered saline (PBS).
4 . The method of claim 1 , further comprising washing the nanostructure loaded with the cargo at least three times.
5 . The method of claim 4 , further comprising storing the nanostructure in the buffer at about 4° C.
6 . The method of claim 1 , wherein the nanostructure is a vesicle-like nanostructure.
7 . The method of claim 6 , wherein the vesicle-like nanostructure has a diameter of less than 240 nm.
8 . The method of claim 1 , wherein the nanostructure is a bundle-like or micellar nanostructure.
9 . The method of claim 1 , wherein the nanostructure consists of PPSU homopolymers.
10 . The method of claim 1 , wherein each of the PPSU homopolymers comprises twenty sulfones.
11 . The method of claim 1 , wherein the cargo is selected from a drug, a protein, a DNA, an RNA, and a siRNA.
12 . The method of claim 11 , wherein the cargo is a protein.
13 . The method of claim 1 further comprising producing the nanostructure from a solution comprising the PPSU homopolymers and a first solvent; and washing the produced nanostructure to remove the first solvent prior to incubating the nanostructure with the cargo.
14 . The method of claim 13 , wherein the cargo has an activity in the first solvent and an activity in the buffer and wherein the activity in the first solvent is lower than the activity in the buffer.
15 . The method of claim 14 , wherein the cargo is selected from a drug, a protein, a DNA, an RNA, and a siRNA.
16 . The method of claim 14 , wherein the cargo is a protein.
17 . The method of claim 14 , wherein the first solvent comprises DMSO.
18 . The method of claim 17 , wherein the buffer comprises phosphate buffered saline (PBS).
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 30, 2025
From: SCOTT, EVAN A.; DU, FANFAN; QIAO, BAOFU; DE LA CRUZ, MONICA OLVERA
To: NORTHWESTERN UNIVERSITY
Reel/Frame 072418/0368 →
Continuity (3)
Provisional Application
62879637
· Jul 29, 2019
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