Methods and systems for blocking neural activity in an organ of a subject, preferably in the small intestine or the duodenum
The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.
1 . A method for reducing neural activity in a duodenum of a subject, the method comprising:
introducing a catheter comprising an electrical energy transducer into the duodenum of the subject;
transmitting electrical energy to the duodenum, wherein the electrical energy is configured to be absorbed by different layers of the duodenum in a target area;
lowering a temperature of the target area utilizing a cooling mechanism, thereby causing selective ablation of sensory nerves located in a submucosal layer of the target area to at least partially reduce the neural activity within the submucosal layer having absorbed the electrical energy, while maintaining functional activity of a mucosal layer within the treated target area and/or functional activity of areas surrounding the treated target area.
2 . The method of claim 1 , wherein the electrical energy transducer is a wire.
3 . The method of claim 1 , wherein the electrical energy transducer is an electrical circuit.
4 . The method of claim 1 , wherein the electrical energy transducer is a capacitor.
5 . The method of claim 1 , wherein the electrical energy is Irreversible Electroporation (IRE) of 1,500 V/cm; with pulse length, 70 μs.
6 . The method of claim 1 , wherein the catheter comprises one or more apertures, and wherein transmitting the electrical energy comprises transmitting the electrical energy through the one or more apertures.
7 . The method of claim 1 , wherein the catheter comprises an inflatable balloon configured to stretch a wall of the duodenum and to position the electrical energy transducer in a center of a lumen of the duodenum.
8 . The method of claim 7 , wherein the inflatable balloon surrounds the electrical energy transducer.
9 . The method of claim 7 , wherein the inflatable balloon is made of a material configured to allow passage of the electrical energy therethrough.
10 . The method of claim 1 , further comprising emitting an ultrasound beam configured for imaging of treated areas of the duodenum.