Pharmaceutical carrier for active substances and a pharmaceutical composition containing said carrier
The present invention relates to a pharmaceutical carrier for active substances characterized in that it contains a strongly solvating aprotic solvent from the group of sulfoxides, a carbonic acid amide, and a vegetable oil with a high content of unsaturated fatty acids, and a pharmaceutical composition containing the carrier.
1 . A pharmaceutical homogeneous carrier for both water-soluble active substances and fat-soluble active substances, characterized in that it contains:
a) a sulfoxide in an amount of 0.01% to 5% by weight,
b) a carbonic acid amide in an amount of 0.01% to 2% by weight, and
c) a vegetable oil selected from the group consisting of Chaulmoogra oil, linseed oil, rapeseed oil, peanut oil, sunflower oil, and hemp oil in an amount of 1% to 5% by weight;
wherein vitamin C dissolves in the carrier at 40° C. and vitamin A dissolves in the carrier at room temperature.
2 . The carrier according to claim 1 , characterized in that the solvating aprotic solvent from the group of sulfoxides is dimethyl sulfoxide.
3 . The carrier according to claim 1 , characterized in that the carbonic acid amide is selected from the group consisting of urea, caffeine and caffeine-containing absorption promoters.
4 . The carrier according to claim 1 , characterized in that it additionally contains a natural emulsifier, selected from the group consisting of white wax, yellow wax, Carnauba wax, and lanolin.
5 . The carrier according to claim 1 , characterized in that it further contains a natural emulsifying substance in an amount of 0.001% to 8% by weight.
6 . A semi-solid pharmaceutical composition characterized in that it contains a carrier as defined in claim 1 , excipients, and at least one active substance, wherein the weight ratio of active substances to the carrier is from 1:10 to 2:1 and the carrier constitutes from 1% to 20% by weight of the composition.
7 . The composition according to claim 6 , characterized in that the weight ratio of the active substances to excipients is from 1:2.5 to 1:494, and it has a semi-solid drug form.
8 . The composition according to claim 6 , characterized in that it contains active substances selected from the group consisting of Coptis Chinesis, Curcuma longa extracts and combinations thereof.
9 . The composition according to claim 6 , characterized in that the excipients are selected from the group consisting of pork lard, duck lard, goose lard, white petrolatum, yellow petrolatum, zinc sulfate, and combinations thereof.
10 . The carrier according to claim 1 , characterized in that the solvating aprotic solvent from the group of sulfoxides is dimethyl sulfoxide and the carbonic acid amide is urea.