Granted Patent B2

US 12,484,607 · App. 17/182,676 · Granted Dec 2, 2025

Inventors: Valter D. Longo (Play del Rey, CA); Chia-Wei Cheng (Los Angeles, CA); Sebastian Brandhorst (Redondo Beach, CA); Min Wei (West Covina, CA); Todd E. Morgan (Manhattan Beach, CA)

Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA

A23L33/40A23L29/37A23L33/115A23L33/15A23L33/155A23L33/16A23L33/17A23L33/175A23L33/30A61K45/00A23V2002/00

Abstract

Claims (19)

1 . A method comprising:

identifying a subject in need of weight reduction having a BMI greater than 30; and

administering a first diet to the subject for a first time period of 5 days, the first diet providing 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet, the first diet providing the subject with at most 50% of the subject's normal caloric intake with at least 50% of the kilocalories being derived from fat, first diet may be administered to the subject with from 700 to 1200 kcal/day, wherein at least the first diet including:

less than 30 g of sugar on the first day;

less than 20 g of sugar on the second to fifth days;

less than 28 g of proteins on the first day;

less than 18 g of proteins on days the second to fifth days;

20 to 30 grams of monounsaturated fats on the first day;

10 to 15 grams of monounsaturated fats on the second to fifth days;

between 6 and 10 grams of polyunsaturated fats on the first day;

3 to 5 grams of polyunsaturated fats on the second to fifth days;

less than 12 g of saturated fats on the first day;

less than 6 grams of saturated fats on the second to fifth days; and

12 to 25 grams of glycerol per day on the second to fifth days; wherein the first diet is provided as soups/broths, soft drinks, nut bars and supplements; and

measuring blood glucose concentration in the subject.

2 . The method of claim 1 further comprising administering a second diet for a second time period to the subject, the second diet providing a subject's normal diet and an overall calorie consumption that is within 10 percent of a subject's normal calorie consumption for 25 to 26 days following the first diet.

3 . The method of claim 2 wherein the combination of the first diet and the second diet provides the subject with a total number of calories within 10 percent of the subject's normal caloric intake.

4 . The method of claim 1 wherein the first diet includes at least 50% of the daily recommended amount of dietary fiber on all days.

5 . The method of claim 1 wherein level of IGF-I decreases and a level of IGFBP1 increases.

Assignments (2)

Continuity (6)

References Cited (148)